ISSN:
1432-0428
Keywords:
Sand rat
;
insulin secretion
;
glucose loading
;
isolated islet
;
insulin content
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A subpopulation (n=27) of normoglycaemic Sand rats was characterized as carbohydrateintolerant by intraperitoneal glucose loading. Five of these animals did not show any rise in peripheral insulin concentrations when injected with glucose. However, when isolated by collagenase digestion their islets still exhibited a significant enhancement of insulin secretion in response to glucose, glyceraldehyde, mannose and theophylline. The in vitro secretory responses were comparable to those of islets from carbohydrate-tolerant Sand rats. The results underline the importance of the natural environment for the B-cell response in vivo.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01236271
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