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Digitale Medien

Apparent discrepancy between the insulin secretory responses in vivo and in vitro in carbohydrate-intolerant sand rats (1979)

Hahn, H. J. ; Gottschling, H. D. ; Schäfer, H.

Springer

Diabetologia 17 (1979), S. 367-369

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Details

ISSN: 1432-0428

Schlagwort(e): Sand rat ; insulin secretion ; glucose loading ; isolated islet ; insulin content

Quelle: Springer Online Journal Archives 1860-2000

Thema: Medizin

Notizen: Summary A subpopulation (n=27) of normoglycaemic Sand rats was characterized as carbohydrateintolerant by intraperitoneal glucose loading. Five of these animals did not show any rise in peripheral insulin concentrations when injected with glucose. However, when isolated by collagenase digestion their islets still exhibited a significant enhancement of insulin secretion in response to glucose, glyceraldehyde, mannose and theophylline. The in vitro secretory responses were comparable to those of islets from carbohydrate-tolerant Sand rats. The results underline the importance of the natural environment for the B-cell response in vivo.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01236271

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