ISSN:
1432-0428
Keywords:
Gangliosides
;
islet transplantation
;
immunosuppression
;
immunomodulation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Streptozotocin-diabetic BdII rats were treated daily with 20 mg/kg body weight gangliosides for ten days beginning two days before transplantation. This treatment did not prolong allograft survival of untreated Lewis islets. Culture treatment of isolated Lewis islets with gangliosides (100 μg/ml in RPMI 1640) for one day resulted in a significant reduction of MHC Ia antigen positive cells but not of class I antigens within the islets. Tranplantation of the ganglioside pretreated islets into non-immunosuppressed BdII recipients prolonged allograft survival to 12 days only in one of five animals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00401049
Permalink