ISSN:
1420-9071
Keywords:
Opioid peptides
;
methionine-enkephalin
;
alcohol-avoiding mice
;
alcohol-preferring mice
;
hypothalamus
;
corpus striatum
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Scrutiny of the data from these studies reveals that the C58/J alcohol-preferring mice have significantly lower baseline methionine-enkephalin levels in both the corpus striatum and hypothalamus compared to C3H/CHRGL/2 non-alcohol-preferring mice. In other brain regions in these two strains, specifically, pituitary, amygdala, midbrain, and hippocampus, analysis of methionine-enkephalin levels did not show any significant differences. This suggests that the hypothalamus may indeed be a specific locus involved in the regulation of alcohol intake, via the molecular interaction between neuroamines, opioid peptides, as they are influenced by genetics and environment.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01940430
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