ISSN:
0021-9304
Keywords:
bone wax
;
hemostasis
;
polyethylene glycol
;
microfibrillar collagen
;
microcrystalline collagen
;
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
,
Technology
Notes:
Although bone wax is effective at achieving hemostasis, it is nonresorbable, causes a foreign body reaction, and inhibits osteogenesis. We report development of a polyethylene glycol/microfibrillar collagen composite (PEG/MFC) that has inherent hemostatic qualities, is biodegradable, and is compatible with bone repair. PEG/MFC composite (n = 42) was placed in 5 mm cranial defects in New Zealand white rabbits. Hemostasis and healing were compared to unfilled defects (n = 32) and defects filled with standard bone wax (n = 10). Both PEG/MFC and bone wax handled well and stopped bleeding. The polyethylene glycol component was resorbed by 8 h, and the microfibrillar collagen was resorbed over 2 months, eliciting only a minor inflammatory response during the first month. Defects filled with the PEG/MFC composite showed similar amounts of bony regeneration as did unfilled control defects. At 4 weeks, healing bone accounted for 43 ± 13% in those treated with PEG/MFC and 47 ± 19% defect area in untreated holes. In contrast, less than 1% of the area was bone in defects filled with bone wax (p 〈 0.05). PEG/MFC composite provided excellent bony hemostasis and did not inhibit bone growth. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 39, 358-363, 1998.
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
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