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  • 1
    Electronic Resource
    Electronic Resource
    Isolation and characterization of human heparin (1992)
    s.l. : American Chemical Society
    Biochemistry 31 (1992), S. 12441-12445 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00164a020
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  • 2
    Electronic Resource
    Electronic Resource
    Predisposition for cysteine substitutions in the immunoglobulin-like chain of FGFR2 in Crouzon syndrome (1995)
    Springer
    Human genetics 〈Berlin〉 96 (1995), S. 113-115 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Four cases of Crouzon syndrome, one familial and three sporadic, were investigated for mutations in exon B of the fibroblast growth factor receptor 2 (FGFR2) gene. In the familial case, a mutation was found at codon 340 that exchanged tyrosine for histidine. Mutations at codon 342, detected in the three sporadic cases, replaced a cysteine by another amino acid. While three of the mutations have been described before, the fourth mutation, a C→G transversion at codon 342 in one of the sporadic cases, has not been recognized previously. Compilation of all exon B mutations in Crouzon syndrome described to date revealed that 6 of the 8 sporadic and 2 of the 9 familial cases have mutations in codon 342. These mutations caused the substitution of cysteine for another amino acid. Given that a mutation in codon 342 was found in 8 out of 17 cases and that in 9 cases the mutation occurred at five additional positions, codon 342 of exon B of the FGFR2 gene may be predisposed to mutations in Crouzon syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00214198
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  • 3
    Electronic Resource
    Electronic Resource
    Hemifacial microsomia: anatomical prediction of difficult intubation (1999)
    Oxford, UK : Blackwell Science Ltd
    Pediatric anesthesia 9 (1999), S. 0 
    Details
    ISSN: 1460-9592
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Hemifacial microsomia (HFM) is associated with a difficult airway. We hypothesized that a difficult intubation would be predicted by radiographic evaluation of the severity of mandibular hypoplasia. A retrospective review of anaesthetic and surgical records of 102 children with HFM from 1986 to 1996 was conducted for radiographic classification of mandibular hypoplasia and degree of difficulty with intubation. Intubation was classified as Grade A—easy, Grade B—difficult, or Grade C—very difficult. The mandibular anatomy was categorized as Type I—‘mini-mandible’, Type II—abnormal condylar size and shape, or Type III—absent ramus, condyle, and temporomandibular joint. In the 82 patients with HFM, 70% were classified as Grade A, 21% had Grade B and 9% had Grade C airways. No patients with Type I mandible had Grade C airway, while 25% of the patients with Type III mandible had Grade C airway. The correlation of the degree of airway difficulty with mandibular type was significant (P=0.001). In 20 patients with bilateral mandibular hypoplasia, 30% had Grade A, 35% had Grade B, and 35% had Grade C airways. We conclude that radiographic classification of mandibular deformity is a useful adjunct for preoperative prediction of airway difficulty in the management of children with unilateral HFM.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9592.1999.00374.x
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  • 4
    Electronic Resource
    Electronic Resource
    Fate of mineralized and demineralized osseous implants in cranial defects (1981)
    Springer
    Calcified tissue international 33 (1981), S. 71-76 
    Details
    ISSN: 1432-0827
    Keywords: Bone matrix ; Induced osteogenesis ; Mineral ; Bone resorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Summary We have evaluated the fate of mineralized and demineralized osseous implants placed into cranial defects in rats. By 2 weeks, 100% of the defects that had been filled with demineralized bone powder (DBP, 75–250 µm) showed bony repair as judged by histomorphometric analysis and incorporation of45Ca. The DBP was not appreciably resorbed but rather was amalgamated within the new bone. Histomorphometric evaluation of osteogenesis induced by equal masses of demineralized bone powders of various particle sizes (〈75, 75–250, 250–450, 〉450 µm) revealed that the smaller particles induced more bone per field than did the larger particles. In contrast, mineralized bone powder (BP) was completely resorbed by 3 weeks, without bony repair of the cranial defect. These specimens contained large multinucleated cells and connective tissue. Implants of bone minerals were also evaluated. Bone ash and deorganified bone powder were surrounded by multinucleated cells within 7 days and completely resorbed by 3 weeks. It is concluded that (a) demineralized bone powder predictably induces osteogenic healing of cranial defects, (b) demineralized bone powder is not appreciably resorbed prior to bone induction, (c) the extent of bone induction is a function of the surface area of the demineralized bone implant, and (d) mineralized bone powder undergoes obligatory resorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02409414
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  • 5
    Electronic Resource
    Electronic Resource
    The mutations in FGFR2-associated craniosynostoses are clustered in five structural elements of immunoglobulin-like domain III of the receptor (1998)
    Springer
    Human genetics 〈Berlin〉 102 (1998), S. 145-150 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Exons 5 and 7 of the fibroblast growth factor receptor 2 (FGFR2) gene code for immunoglobulin-like domain III (IgIII) and for the region connecting the second and the third Ig domain of the receptor. Numerous mutations in these two exons have been shown to cause various craniosynostotic syndromes. Here, we describe three previously unrecognized mutations at amino acid positions 276, 301, and 314, in one nonspecific craniosynostosis and in two Crouzon patients. We also present a polypeptide model of IgIII of FGFR2. The known mutations involve five distinct structural elements of the receptor. The changes within these elements affect receptor function by various mechanisms, including altered dimerization, truncation, increased mobility between Ig domains, disintegration of IgIII, and alteration of the ligand-binding site.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050668
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  • 6
    Electronic Resource
    Electronic Resource
    Cross-Cultural Understanding of Aesthetic Surgery: The Male Cosmetic Surgery Patient in Japan and the USA (2000)
    Springer
    Aesthetic plastic surgery 24 (2000), S. 283-288 
    Details
    ISSN: 1432-5241
    Keywords: Key words: Cross-cultural—Aesthetic (cosmetic) surgery—Body dysmorphic disorder—Surgical complication
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. This review describes the historical development of aesthetic surgery in Japan and parallels with the development of the specialty in the United States. The focus is on the consequences of aesthetic surgery in the male patient when collaboration between mental health clinicians and surgeons lags. The cultural, social, and psychological issues raised are relevant to the diverse cultural groups now seeking aesthetic surgery in the United States. Case illustrations are a reminder to aesthetic surgeons of the potential need for more comprehensive evaluation in the group of male patients who may be at added risk for negative outcomes in terms of satisfaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002660010047
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  • 7
    Electronic Resource
    Electronic Resource
    Polyethylene glycol/microfibrillar collagen composite as a new resorbable hemostatic bone wax (1998)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 39 (1998), S. 358-363 
    Details
    ISSN: 0021-9304
    Keywords: bone wax ; hemostasis ; polyethylene glycol ; microfibrillar collagen ; microcrystalline collagen ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Although bone wax is effective at achieving hemostasis, it is nonresorbable, causes a foreign body reaction, and inhibits osteogenesis. We report development of a polyethylene glycol/microfibrillar collagen composite (PEG/MFC) that has inherent hemostatic qualities, is biodegradable, and is compatible with bone repair. PEG/MFC composite (n = 42) was placed in 5 mm cranial defects in New Zealand white rabbits. Hemostasis and healing were compared to unfilled defects (n = 32) and defects filled with standard bone wax (n = 10). Both PEG/MFC and bone wax handled well and stopped bleeding. The polyethylene glycol component was resorbed by 8 h, and the microfibrillar collagen was resorbed over 2 months, eliciting only a minor inflammatory response during the first month. Defects filled with the PEG/MFC composite showed similar amounts of bony regeneration as did unfilled control defects. At 4 weeks, healing bone accounted for 43 ± 13% in those treated with PEG/MFC and 47 ± 19% defect area in untreated holes. In contrast, less than 1% of the area was bone in defects filled with bone wax (p 〈 0.05). PEG/MFC composite provided excellent bony hemostasis and did not inhibit bone growth. © 1998 John Wiley & Sons, Inc. J Biomed Mater Res, 39, 358-363, 1998.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
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