ISSN:
1573-7217
Keywords:
histologic grading
;
node-negative breast cancer
;
nuclear pleomorphism
;
prognostic factors
;
tumor grade
;
tumor size
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We have evaluated established risk factors (tumor size, menopausal status, receptor status, tumor histology, and grading according to Bloom & Richardson including subfactor analysis) as well as local therapeutic procedures in a series of 121 patients with axillary node-negative (ANN) breast cancer stage T1a and T1b. The patients were operated on at a single institution (Department of Surgery, Hanuschkrankenhaus, Vienna) from 1969 to 1989. After a median observation time of 185 months, a total of 16 patients (13%) had a recurrence; of these, 6 had died of the primary disease by the control date (Dec 1, 1990). Grading (distant recurrence-free survival (DRFS) p=0.01, overall survival (OS) p=0.006, mitosis rate (DRFS p=0.006, OS p=0.02), and particularly nuclear pleomorphism (DRFS p=0.0002, OS p=0.00001) proved to have prognostic impact on distant recurrence-free survival and/or overall survival (Mantel-Cox log rank test; level of significance: p=0.006 after adjustment for multiple testing by Bonferroni correction). Therapeutic procedures had a borderline-significant impact on local recurrence (p=0.09). No other parameters had statistically significant impact. Thus, our long-term analysis confirms the superior prognostic relevance of histologic grading and nuclear pleomorphism in patients with ANN breast cancer stage T1a and T1b.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01834640
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