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  • 1
    Electronic Resource
    Electronic Resource
    Der scheinbare Verteilungsraum von 131J-Albumin in verschiedenen Schichten der Niere bei Diurese und Antidiurese (1962)
    Springer
    Pflügers Archiv 276 (1962), S. 236-241 
    Details
    ISSN: 1432-2013
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Der scheinbare Verteilungsraum für 131J-Albumin wurde 15 min nach der Injektion in verschiedenen Schichten der Rattenniere bestimmt. Stets fand sich ein Anstieg des Verteilungsraumes von der Rinde zur Papillenspitze hin. Dieser Anstieg war bei Tieren in Antidiurese stärker als bei Tieren in osmotischer oder Wasserdiurese. Der Unterschied im Verteilungsraum bei Diurese und Antidiurese ist zum Teil durch Anreicherung von ungebundenem 131Jod im Mark vorgetäuscht. Bei durstenden Tieren wird 131Jodid (nach Injektion von K131J) im Papillengewebe um den Faktor 3,8 konzentriert, in Wasserdiurese um den Faktor 1,2. Wird der Verteilungsraum für 131J-Albumin entsprechend dem Anteil von ungebundenem 131Jod korrigiert, bleibt im Mittel der Verteilungsraum in der inneren Markzone bei Antidiurese um den Faktor 1,2 höher als bei Diurese. Obwohl dieser Unterschied statistisch nicht signifikant ist, wird er als Hinweis auf die Möglichkeit angesehen, daß die Eiweißkonzentration im vasa recta-Plasma bei Antidiurese höher als bei Diurese ist. Das würde bedeuten, daß die Konzentrierung des vasa recta-Plasmas nicht nur durch einen Einwärtsstrom von Elektrolyten, sondern auch durch einen Auswärtsstrom (Nettofluß) von Wasser zustande kommt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00362606
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Nuclear pleomorphism, a strong prognostic factor in axillary node-negative small invasive breast cancer (1991)
    Springer
    Breast cancer research and treatment 20 (1991), S. 109-116 
    Details
    ISSN: 1573-7217
    Keywords: histologic grading ; node-negative breast cancer ; nuclear pleomorphism ; prognostic factors ; tumor grade ; tumor size
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have evaluated established risk factors (tumor size, menopausal status, receptor status, tumor histology, and grading according to Bloom & Richardson including subfactor analysis) as well as local therapeutic procedures in a series of 121 patients with axillary node-negative (ANN) breast cancer stage T1a and T1b. The patients were operated on at a single institution (Department of Surgery, Hanuschkrankenhaus, Vienna) from 1969 to 1989. After a median observation time of 185 months, a total of 16 patients (13%) had a recurrence; of these, 6 had died of the primary disease by the control date (Dec 1, 1990). Grading (distant recurrence-free survival (DRFS) p=0.01, overall survival (OS) p=0.006, mitosis rate (DRFS p=0.006, OS p=0.02), and particularly nuclear pleomorphism (DRFS p=0.0002, OS p=0.00001) proved to have prognostic impact on distant recurrence-free survival and/or overall survival (Mantel-Cox log rank test; level of significance: p=0.006 after adjustment for multiple testing by Bonferroni correction). Therapeutic procedures had a borderline-significant impact on local recurrence (p=0.09). No other parameters had statistically significant impact. Thus, our long-term analysis confirms the superior prognostic relevance of histologic grading and nuclear pleomorphism in patients with ANN breast cancer stage T1a and T1b.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01834640
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  • 3
    Electronic Resource
    Electronic Resource
    A prospective analysis of immunohistochemically determined hormone receptors and nuclear features as predictors of early recurrence in primary breast cancer (1995)
    Springer
    Breast cancer research and treatment 36 (1995), S. 11-21 
    Details
    ISSN: 1573-7217
    Keywords: primary breast cancer ; steroid receptors ; immunohistochemistry ; histologic grading ; prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The immunohistochemnichally determined receptor status, as well as first-generation risk factors (tumor size, lymph node status, histologic grading including subfactors, tumor histology, and biochemically determined receptor status) were prospectively analyzed in 288 cases of primary breast cancer for their impact on recurrence-free survival (RFS) and overall survival (OS) after a median observation period of 41 months. Immunohistochemically (ER-ICA) and biochemically determined estrogen receptors (ER-DCC), as well as tumor size, lymph node status, histologic grading, mitotic rate, and nuclear polymorphism, were of prognostic value for recurrence-free survival and/or overall survival. In multivariate analysis, lymph node status, tumor size, and mitotic rate proved to be independent prognosticators; ER-ICA showed significance in the univariate analysis which dropped, however, when multivariate analysis was applied. The prognostic power of histologic grading in our series seemed to depend mainly on the subfactors which relate to nuclear features.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690180
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  • 4
    Electronic Resource
    Electronic Resource
    Comparison of immunohistochemical and biochemical measurement of steroid receptors in primary breast cancer: Evaluation of discordant findings (1998)
    Springer
    Breast cancer research and treatment 50 (1998), S. 125-134 
    Details
    ISSN: 1573-7217
    Keywords: biochemical assay ; primary breast cancer ; discordant findings ; immunohistochemistry ; steroid receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tumor samples of 240 patients with primary breast cancer were biochemically and immunohistochemically investigated for estrogen receptors (ER) and, in 130 of the samples, for progesterone-receptors (PgR) in order to examine reasons for discordant findings. The biochemical (DCCA) and immunohistochemical assays (ICA) yielded positivity in 71% for ER, and in 44% for PgR. Concordant ER-DCCA and ER-ICA results were obtained in 84%; two thirds of the discordant ER-findings manifested as DCCA-neg/ICA-pos. Concordance in the case of PgR amounted to 72%, and of the discordances 60% were DCCA-neg/ICA-pos. Significant association with postmenopausal status existed only for ER positivity in ICA (p=0.01), whereas ER-DCCA, PgR-DCCA and PgR-ICA were all more or less independent of the menopausal status. The frequency of discordances was independent of menopausal status. Discordance for ER-assays increased significantly near the respective cut-off point; this was not unequivocally true for PgR-assays. The correlation of tumor types of sparse cellularity, as well as prominent stroma content (‘scirrhous carcinoma’) with increased frequency of the constellation DCCA-neg/ICA-pos was of borderline significance for PgR (p=0.06), but not for ER. The percentage of discordant ER-findings, figuring as DCCA-neg/ICA-pos, was statistically significantly increased in locally advanced breast cancer (p=0.03). Fibrocystic disease in peritumoral breast tissue had no impact on receptor-assay discordance. In any case, the models derived from theoretical thought, laboratory data and singular observations can only in part explain the discordance in steroid receptor values measured with different methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006046107249
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    Paper (German National Licenses)
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