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  • 1
    Electronic Resource
    Electronic Resource
    Site of reaction of a specific diazo inactivator of pepsin (1970)
    s.l. : American Chemical Society
    Biochemistry 9 (1970), S. 4624-4632 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00826a002
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  • 2
    Electronic Resource
    Electronic Resource
    Frequency of ΔF508 mutation and haplotype analysis in Austrian cystic fibrosis families (1992)
    Springer
    Human genetics 〈Berlin〉 89 (1992), S. 464-465 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194327
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  • 3
    Electronic Resource
    Electronic Resource
    Oestrogen and progesterone receptor content as a prognostic factor in advanced epithelial ovarian carcinoma (1990)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 97 (1990), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Levels of oestrogen receptor (ER) and progesterone receptor (PgR) in ovarian cancer tissue were examined with regard to their prognostic importance for survival in 179 patients with primary epithelial ovarian cancer stage III or IV in relation to: FIGO-stage, histological type, histological grade, age, ascites, and postoperative residual tumour. Hormone receptor content was determined with the DCC-method, receptor values higher than 9 fmol/mg protein were considered positive. Response to postoperative chemotherapy was significantly correlated with PgR content (80% responders in the group with PgR positive tumours and only 61% responders in the group with PgR negative tumours). A Cox proportional hazards regression model identified histological grade, residual tumour, age and PgR content as independent prognostic factors for survival in advanced epithelial ovarian carcinoma. PgR content had particularly significant prognostic relevance for patients with postoperative residual tumour mass ≤2 cm in diameter. Within this group of patients, those who are PgR positive have a 2-years survival probability of 83% compared with only 51% in the Pg R-negative group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1990.tb16243.x
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  • 4
    Electronic Resource
    Electronic Resource
    Sex steroid hormone receptor analysis in malignant melanoma (1982)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 107 (1982), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Melanomas, as well as benign pigmented nevi, long-term cell cultures of melanoma cells and sixty-six normal skin biopsies, were evaluated for oestrogen and androgen receptor activity by a dextran-coated charcoal method.Oestrogen-binding was observed in 16% and androgen-binding in 40% of all investigated tumours. Normal skin showed 4% oestrogen and 41% androgen receptor activity; melanoma cell cultures expressed the same sex steroid hormone binding as tumour material. The quantitative receptor expression was found to be significantly higher in female than in male melanoma patients.Even though the study shows that to a certain extent malignant melanoma is a hormone dependent tumour, it seems that sex steroid hormones are not exclusively related to the biological behaviour of this tumour. In future, investigations should be expanded to other hormonal influences.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1982.tb01032.x
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  • 5
    Electronic Resource
    Electronic Resource
    Ultrastructural and immunohistochemical characteristics of lipid-rich carcinoma of the breast (1988)
    Springer
    Virchows Archiv 413 (1988), S. 381-385 
    Details
    ISSN: 1432-2307
    Keywords: Lipid rich carcinoma ; Breast ; Immunohistochemistry ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Five cases of lipid-rich carcinomas of the breast were investigated ultrastructurally and immunohistochemically for alpha-lactalbumin (ALA), lactoferrin (Lfr) and human milk fat globule membrane antigen (HMFG-2). Staining for ALA and Lfr showed intensive reaction on nearly all of the tumour cells whereas immunoreaction for HMFG-2 revealed positivity in single cells. All tumours were negative for steroid receptor content. Ultrastructurally the tumour cells showed numerous intracytoplasmic non-membrane bound lipid droplets which were often found within autophagocytic vacuoles. Neither rough endoplasmic reticulum nor Golgi complexes showed any sign of lipid synthesis. Extrusion of lipid droplets and extracellular lipid deposition was not observed. In conclusion, our findings do not justify the consideration of lipid-rich carcinoma of the breast as a clearly defined group of tumours with specific secretory activity. Therefore, the term lipid-rich carcinoma should be used in preference to lipid-secreting, unless there is evidence of active lipid secretion.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00716986
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  • 6
    Electronic Resource
    Electronic Resource
    A prospective analysis of immunohistochemically determined hormone receptors and nuclear features as predictors of early recurrence in primary breast cancer (1995)
    Springer
    Breast cancer research and treatment 36 (1995), S. 11-21 
    Details
    ISSN: 1573-7217
    Keywords: primary breast cancer ; steroid receptors ; immunohistochemistry ; histologic grading ; prognostic factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The immunohistochemnichally determined receptor status, as well as first-generation risk factors (tumor size, lymph node status, histologic grading including subfactors, tumor histology, and biochemically determined receptor status) were prospectively analyzed in 288 cases of primary breast cancer for their impact on recurrence-free survival (RFS) and overall survival (OS) after a median observation period of 41 months. Immunohistochemically (ER-ICA) and biochemically determined estrogen receptors (ER-DCC), as well as tumor size, lymph node status, histologic grading, mitotic rate, and nuclear polymorphism, were of prognostic value for recurrence-free survival and/or overall survival. In multivariate analysis, lymph node status, tumor size, and mitotic rate proved to be independent prognosticators; ER-ICA showed significance in the univariate analysis which dropped, however, when multivariate analysis was applied. The prognostic power of histologic grading in our series seemed to depend mainly on the subfactors which relate to nuclear features.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690180
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  • 7
    Electronic Resource
    Electronic Resource
    Comparison of immunohistochemical and biochemical measurement of steroid receptors in primary breast cancer: Evaluation of discordant findings (1998)
    Springer
    Breast cancer research and treatment 50 (1998), S. 125-134 
    Details
    ISSN: 1573-7217
    Keywords: biochemical assay ; primary breast cancer ; discordant findings ; immunohistochemistry ; steroid receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tumor samples of 240 patients with primary breast cancer were biochemically and immunohistochemically investigated for estrogen receptors (ER) and, in 130 of the samples, for progesterone-receptors (PgR) in order to examine reasons for discordant findings. The biochemical (DCCA) and immunohistochemical assays (ICA) yielded positivity in 71% for ER, and in 44% for PgR. Concordant ER-DCCA and ER-ICA results were obtained in 84%; two thirds of the discordant ER-findings manifested as DCCA-neg/ICA-pos. Concordance in the case of PgR amounted to 72%, and of the discordances 60% were DCCA-neg/ICA-pos. Significant association with postmenopausal status existed only for ER positivity in ICA (p=0.01), whereas ER-DCCA, PgR-DCCA and PgR-ICA were all more or less independent of the menopausal status. The frequency of discordances was independent of menopausal status. Discordance for ER-assays increased significantly near the respective cut-off point; this was not unequivocally true for PgR-assays. The correlation of tumor types of sparse cellularity, as well as prominent stroma content (‘scirrhous carcinoma’) with increased frequency of the constellation DCCA-neg/ICA-pos was of borderline significance for PgR (p=0.06), but not for ER. The percentage of discordant ER-findings, figuring as DCCA-neg/ICA-pos, was statistically significantly increased in locally advanced breast cancer (p=0.03). Fibrocystic disease in peritumoral breast tissue had no impact on receptor-assay discordance. In any case, the models derived from theoretical thought, laboratory data and singular observations can only in part explain the discordance in steroid receptor values measured with different methods.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006046107249
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