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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Diabetologia 9 (1973), S. 303-306 
    ISSN: 1432-0428
    Keywords: Adipose tissue ; ob/ob mice ; isolated fat cells ; cell size ; cell number ; plasma volume ; nitrogen content
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 1. The nitrogen content, total water content,in vivo 125l-albumin space, the number and size of adipocytes per unit wet weight of epididymal fat pad and the plasma volume have been studied in lean and obese mice, and in obese mice on chronic restriction of their food intake. — 2. There were fewer, larger adipocytes per unit wet weight of tissue (in young obese mice) with a proportional decrease in the vascular space and water content, and the same nitrogen content as had epididymal adipose tissue from lean mice. — 3. There was a reduction in the nitrogen content of epididymal adipose tissue from obese mice on a restricted diet. — 4. These findings are discussed in relation to the reduced glucose metabolism and lipolysis that are apparent when metabolic data are expressed per unit wet weight.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1619-1560
    Keywords: sweat gland ; substance P ; vasoactive intestinal polypeptide ; diabetic neuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Vasoactive intestinal polypeptide (VIP) and substance P (SP) immunoreactivity are reduced in the cutaneous nerves of diabetic patients with peripheral neuropathy. The functional significance of this finding was studied by measuring the forearm sweat response to intradermal methacholine and the effect of coadministration of VIP and SP in six normal subjects, and in six diabetic patients with neuropathy and eight without. Flare responses to the two peptides were also measured. Methacholine-induced sweat output was significantly greater in neuropathic patients compared with the other groups (p 〈 0.05), suggesting upper limb denervation supersensitivity. VIP and SP alone did not evoke sweating in any subject. Injection of VIP or SP reduced methacholine-induced sweating to a similar degree in all groups, except that the reduction was smaller in the nonneuropathic group than in the others (p = 0.028 versus normal subjects, p = 0.014 versus neuropathic diabetic patients). Flare responses to the peptides were markedly reduced in the neuropathic patients compared with the other groups (p 〈 0.01). In neuropathic patients, increased sweat responses and decreased flare coexist with diminished neurophysiological measurements; cutaneous sweating and flare responses provide valuable additional information to conventional methods of neurological assessment in diabetic neuropathy.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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