ISSN:
0006-3592
Keywords:
poly-β-hydroxybutyric acid
;
Alcaligenes eutrophus
;
fed-batch culture
;
high cell density culture
;
optimization
;
Chemistry
;
Biochemistry and Biotechnology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
The optimal feed rate profiles of glucose and ammonium hydroxide were calculated using a proposed model, and implemented for the production of poly-β-hydroxybutyric acid (PHB) by Alcaligenes eutrophus. By implementing these optimal feed rates with a high glucose feed concentration of 700 g/L and an ammonium hydroxide concentration of 7%(w/w), it was possible to achieve a high final cell concentration of 141 g/L and a high PHB concentration of 105 g/L in 40 h of fed-batch operation. The PHB productivity was as high as 2.63 g/(L hr). © 1997 John Wiley & Sons, Inc. Biotechnol Bioeng 56: 697-705, 1997.
Additional Material:
7 Ill.
Type of Medium:
Electronic Resource
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