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  • pharmacokinetic effects  (1)
  • pharmacokinetics  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Pharmacodynamics and urine pharmacokinetics of three doses of piretanide (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 783-785 
    Details
    ISSN: 1432-1041
    Keywords: piretanide ; urine K+ and Na+ clearance ; pharmacodynamic effects ; pharmacokinetic effects ; diuretic effects ; dose-response relationship ; trial design
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Three doses (3 mg, 6 mg and 12 mg) of piretanide, a new high ceiling diuretic, and placebo were given to 8 volunteers to investigate the relationship between the pharmacodynamic parameters, the dose and its urinary excretion. Intake of food and fluid were standardized from 48 h before until 24 h after drug administration. Urinary output, excretion of unchanged drug, and the excretion and clearance of Na+ and K+ were measured hourly for 7 h after treatment. A clear dose-response relationship was found for cumulative urinary output, cumulative excretion of Na+ and K+, clearance of Na+ and K+ and the urinary sodium/potassium ratio. A significant correlation was found between the net urine volume and the excretion of piretanide per time interval. The clearances of Na+ and K+ were significantly correlated with the excretion of piretanide. Clearance values correlated well with corresponding urine volumes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542520
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Influence of experimental rhinitis on the gonadotropin response to intranasal administration of buserelin (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 155-159 
    Details
    ISSN: 1432-1041
    Keywords: buserelin ; LHRH superagonist ; histamine-induced rhinitis ; pharmacokinetics ; serum LH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of experimental rhinitis on the absorption of buserelin, measured as the serum luteinizing hormone (LH) response, has been investigated. A single dose of 200 µg buserelin was given to 24 healthy male volunteers after induction of experimental rhinitis with histamine and after use of a saline spray (placebo control). Except on one occasion, when the pump-spray apparently was incorrectly operated, serum LH concentration rose after buserelin. There was no difference in the LH response between histamine-induced rhinitis and saline controls. It was concluded that intranasal application of buserelin represents a reliable mode of application and that modification of the administration route or a change in the dosage schedule during naturally-occurring nasal inflammations, such as the common cold and allergic rhinitis, is unnecessary in patients undergoing chronic treatment with intranasal buserelin, e.g. for prostatic cancer, endometriosis, precocious puberty, and contraception.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544560
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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