Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Treatment of uremic bone disease action of 5,6-trans-25-hydroxycholecalciferol (a vitamin D-analog) in chronic renal failure (1973)
    Springer
    Journal of molecular medicine 51 (1973), S. 979-981 
    Details
    ISSN: 1432-1440
    Keywords: Uremic Bone Disease ; Vitamin D-Treatment ; Vitamin D-Analogs ; 47Ca-Absorption ; Urämische Osteopathie ; Vitamin D-Behandlung ; Vitamin D-Analoge ; 47Calcium-Absorption
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die biologische Aktivität von 5,6-trans-25-Hydroxycholecalciferol wurde bei Patienten mit terminaler Niereninsuffizienz untersucht. Alle Patienten erhielten über einen Zeitraum von 6 Tagen täglich 100 U dieser Substanz intravenös. Nach dieser Therapie fand sich ein Anstieg der Absorption von47Calcium bei 4 Patienten sowie bei allen ein Anstieg des Serumcalciums. Die Ergebnisse lassen hoffen, daß 5,6-trans-25-Hydroxycholecalciferol schon in niedriger Dosierung eine nützliche Therapie der urämischen Osteopathie sein könnte, um so mehr, als diese Substanz kein Calcium aus dem Knochen mobilisiert.
    Notes: Summary Investigations were performed in order to test the biological effectiveness of 5,6-trans-25-hydroxycholecalciferol in patients suffering from terminal renal failure. All patients received for six days a daily i.v. injection of 100 U of this compound: The absorption of47calcium increased in four of five patients, the serum calcium level rose in all. The data suggest that 5,6-trans-25-hydroxycholecalciferol may be useful in the treatment of uremic bone disease, especially because this compound has little, if any, activity in stimulating the mobilization of calcium from the bone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01468254
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Influence of experimental rhinitis on the gonadotropin response to intranasal administration of buserelin (1987)
    Springer
    European journal of clinical pharmacology 33 (1987), S. 155-159 
    Details
    ISSN: 1432-1041
    Keywords: buserelin ; LHRH superagonist ; histamine-induced rhinitis ; pharmacokinetics ; serum LH
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The influence of experimental rhinitis on the absorption of buserelin, measured as the serum luteinizing hormone (LH) response, has been investigated. A single dose of 200 µg buserelin was given to 24 healthy male volunteers after induction of experimental rhinitis with histamine and after use of a saline spray (placebo control). Except on one occasion, when the pump-spray apparently was incorrectly operated, serum LH concentration rose after buserelin. There was no difference in the LH response between histamine-induced rhinitis and saline controls. It was concluded that intranasal application of buserelin represents a reliable mode of application and that modification of the administration route or a change in the dosage schedule during naturally-occurring nasal inflammations, such as the common cold and allergic rhinitis, is unnecessary in patients undergoing chronic treatment with intranasal buserelin, e.g. for prostatic cancer, endometriosis, precocious puberty, and contraception.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544560
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Cefodizime penetration into skin suction blister fluid following a single intravenous dose (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 295-298 
    Details
    ISSN: 1432-1041
    Keywords: cefodizime ; skin suction blister fluid ; pharmacokinetics ; protein binding ; healthy subjects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Cefodizime pharmacokinetics was investigated, evaluating drug concentrations in serum, skin suction blister fluid (SBF), saliva and urine in six healthy male subjects who were administered a 1-g dose intravenously. Serum levels in five subjects can be described according to a two-compartment open model; terminal half-life is 181±14 min. Volume of distribution (Vdβ) amounts to 15.3±1.61, serum clearance to 59±6 ml/min, renal clearance to 33±3 ml/min. Of the administered dose, 54% is renally excreted unchanged within 27 h. Unbound drug fraction in serum is 19.0% and in SBF 38.4%. Thus renal clearance of free cefodizime amounts to 172 ml/min, Vdss to 68.91 (free drug). Whereas cefodizime has not been detected in saliva samples, SBF concentration 3–9 h post administration parallel serum levels, amounting to 40% of the respective serum concentration. At 9 h, unbound cefodizime concentrations in SBF amount to 1.4±0.4 µg/ml, this value being well above the MIC90% values of many clinically relevant bacteria.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00541531
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Pharmacokinetic aspects of the interaction between clobazam and cimetidine (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 139-142 
    Details
    ISSN: 1432-1041
    Keywords: clobazam ; cimetidine ; N-desmethylclobazam ; kinetic interaction ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetic interaction between clobazam and cimetidine was studied in 9 healthy male volunteers in an open-labelled study. After a single oral dose of clobazam 30 mg, a wash-out period of 14 days was followed by daily doses of cimetidine 1 g for one week. Thereafter a single oral dose of clobazam 30 mg was again given. The plasma concentrations of clobazam and its main metabolite N-desmethyl-clobazam were measured by gas-chromatography. The area under the curve (AUC0−∞) of plasma clobazam level was significantly larger after pretreatment with cimetidine and the elimination half life of clobazam was significantly longer. There were no statistically significant differences in Cmax and tmax for plasma clobazam. The plasma levels of N-desmethyl-clobazam did not show any significant change after the intake of cimetidine.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00544031
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Pharmacodynamics and urine pharmacokinetics of three doses of piretanide (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 783-785 
    Details
    ISSN: 1432-1041
    Keywords: piretanide ; urine K+ and Na+ clearance ; pharmacodynamic effects ; pharmacokinetic effects ; diuretic effects ; dose-response relationship ; trial design
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Three doses (3 mg, 6 mg and 12 mg) of piretanide, a new high ceiling diuretic, and placebo were given to 8 volunteers to investigate the relationship between the pharmacodynamic parameters, the dose and its urinary excretion. Intake of food and fluid were standardized from 48 h before until 24 h after drug administration. Urinary output, excretion of unchanged drug, and the excretion and clearance of Na+ and K+ were measured hourly for 7 h after treatment. A clear dose-response relationship was found for cumulative urinary output, cumulative excretion of Na+ and K+, clearance of Na+ and K+ and the urinary sodium/potassium ratio. A significant correlation was found between the net urine volume and the excretion of piretanide per time interval. The clearances of Na+ and K+ were significantly correlated with the excretion of piretanide. Clearance values correlated well with corresponding urine volumes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00542520
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Absorption of glibenclamide from different sites of the gastro-intestinal tract (1985)
    Springer
    European journal of clinical pharmacology 29 (1985), S. 193-197 
    Details
    ISSN: 1432-1041
    Keywords: Glibenclamide ; intestinal absorption ; small and large intestine ; bioavailability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In a study of eight volunteers and six patients, glibenclamide was placed at different sites of the gastro-intestinal tract under visual control. The dose was instilled once into the stomach and once into the duodenum of the eight volunteers in a randomized crossover design. The six patients underwent diagnostic colonoscopy, and the dose was placed into the ascending colon if pathological findings were not present. The area under the concentration-time curve, completed by extrapolation, and the mean residence time of the drug in the body were calculated. These pharmacokinetic characteristics were examined using a Jonckheere test for ordered alternatives and a Wilcoxon signed rank pair test. The means of the areas under the curve were 477±131 ng·h ml−1 for the stomach, 475±142 ng·h ml−1 for the duodenum and 486±301 ng·h ml−1 for the colon. The mean residence time changed from 2.67±0.35 h for the stomach to 2.42±0.48 h for the duodenum and 3.55±0.68 h for the colon. These results indicate that although glibenclamide is absorbed from all three sites of the gastro-intestinal tract to the same extent, the rates of absorption are different. It is discussed whether these findings really confirm the pH-partition hypothesis in drug absorption. Since glibenclamide — a weak acid — has a pK-value of about 6.5, these data seem to confirm the pH-partition hypothesis of drug absorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00547421
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    The absorption of piretanide from the gastro-intestinal tract is site-dependent (1986)
    Springer
    European journal of clinical pharmacology 30 (1986), S. 79-82 
    Details
    ISSN: 1432-1041
    Keywords: piretanide ; gastro-intestinal absorption ; mean absorption time ; stomach ; duodenum ; colon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The absorption of piretanide was investigated after placing the drug in the stomach, duodenum and ascending colon under visual control. The relative amounts absorbed and the rates of absorption were estimated from the area under the curve and the total mean time, respectively. Similar amounts of piretanide were absorbed and at almost the same rate after placement in the stomach and duodenum; the area under the curve for the stomach was 250 ng h/ml and for the duodenum 243 ng h/ml, the mean absorption times being 1.97 h and 1.51 h respectively. A marked difference was observed in the rate of from the ascending colon; the area amounted to 66 ng h/ml and the mean time to 3.99 h. Although area values for the colon were significantly different from those observed with the stomach and duodenum, it must be emphasised that the amount absorbed depends on the time the drug is in contact with the absorbing surface. There is discussion of whether the differences in absorption between the duodenum and colon can be explained by the physico-chemical properties of the drug alone, or whether the results reflect a saturable transport mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00614200
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    The effect of pentoxifylline on the 3',5'-cyclic AMP-system in bovine platelets
    Amsterdam : Elsevier
    International Journal of Biochemistry 8 (1977), S. 359-364 
    Details
    ISSN: 0020-711X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0020-711X(77)90005-2
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Red blood cell aging as a model to influence pharmacologically the red cell filterability (1981)
    Springer
    Research in experimental medicine 179 (1981), S. 249-254 
    Details
    ISSN: 1433-8580
    Keywords: Red cells ; Aging ; Red cell filterability ; Pharmacologic screening
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A method to filter whole blood through 5-µm filters at a pressure of 20 cm column of water and the use of aging red cells as a reproducible procedure to generate rigidified cells is described. The system is sensitive enough to evaluate in pharmacologic screening possible influences of chemical agents on red cell deformability. Investigations with the methylxanthine derivates pentoxifylline and theophylline, the beta-blocker penbutolol and prednisolone, revealed that only the first compound has a dose-dependent effect on red cell deformability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851622
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of 5,6-trans-25-hydroxycholecalciferol, a synthetic analogue of vitamin D3, in man (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 255-260 
    Details
    ISSN: 1432-1041
    Keywords: Vitamin D ; renal osteodystrophy ; 5,6-trans-25-hydroxycholecalciferol ; rickets ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Vitamin D analogues of high biological activity are probably useful in the treatment of renal osteodystrophy. The pharmacokinetics of the synthetic compound 5,6-trans-25-hydroxycholecalciferol have been studied in healthy subjects who were of normal vitamin D status. In comparison to natural 25-hydroxy-cholecalciferol, serum levels of the analogue were lower and its half-life in blood after oral or intravenous administration was considerably shorter. In normal subjects no increase of dihydroxylated metabolites in serum was observed within seven days of an intravenous dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00567124
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...