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  • 1
    Electronic Resource
    Electronic Resource
    Immunoreaktives Parathormon, 25-Hydroxycalciferol und Knochenhistologie bei renaler Osteopathie (1976)
    Springer
    Journal of molecular medicine 54 (1976), S. 625-632 
    Details
    ISSN: 1432-1440
    Keywords: Renal osteodystrophy ; Parathyroid hormone ; Vitamin D ; 25-Hydroxycalciferol ; Bone biopsy ; Renale Osteopathie ; Parathormon ; Vitamin D ; 25-Hydroxycalciferol ; Knochenbiopsie
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 32 Patienten mit renaler Osteopathie wurden die Serumspiegel des immunoreaktiven Parathormons (iPTH) und des 25-Hydroxycalciferol (25(OH)D) bestimmt und mit den Ergebnissen der Knochenbiopsie und anderen klinischen Parametern korreliert. Das iPTH entsprach den Ergebnissen der Knochenhistologie, zeigte jedoch keine Beziehung zum Serumcalcium und der alkalischen Phosphatase, während eine statistisch signifikante Korrelation mit dem Serumphosphat bestand. Die 25(OH)D-Spiegel verhielten sich unabhängig vom histologischen Nachweis einer Osteomalazie oder vermehrter Knochenresorption, es fand sich eine Beziehung zwischen dem Vitamin-D-Metaboliten und dem Serumcalcium. Da die iPTH- und die 25(OH)D-Spiegel eine signifikante inverse Korrelation zeigten, wurde ein inhibitorischer Effekt des 25(OH)D auf die Nebenschilddrüsenfunktion bei Niereninsuffizienz diskutiert.
    Notes: Summary Immunoreactive parathyroid hormone (iPTH) and 25-hydroxycalciferol (25(OH)D) serum levels were determined in 32 patients with renal osteopathy, they were correlated with the results of bone biopsy and other clinical parameters. iPTH was closely related to bone histology, it did not correspond to serum calcium and alkaline phosphatase, but the correlation to serum phosphate was statistically significant. 25(OH)D levels were not related to the histological findings of osteomalacia or increased bone resorption, while a correlation between the vitamin D metabolite and serum calcium could be observed. Since iPTH and 25(OH)D levels exhibited a significant correlation, an inhibitory effect of 25(OH)D on parathyroid gland function in renal failure was discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01469028
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  • 2
    Electronic Resource
    Electronic Resource
    Immunreaktives Parathormon im Schilddrüsenvenenblut (1978)
    Springer
    Journal of molecular medicine 56 (1978), S. 1007-1012 
    Details
    ISSN: 1432-1440
    Keywords: Hyperparathyroidism ; Immunoreactive parathyroid hormone ; Selectively catheterized thyroid veins ; Hyperparathyreoidismus ; Immunreaktives Parathormon ; Selektiv sondierte Schilddrüsenvenen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 16 Patienten mit primärem oder sekundärem Hyperparathyreoidismus wurden selektiv Blutproben aus den Hals- und Schilddrüsenvenen gewonnen. Das immunreaktive Parathormon wurde mit zwei aminoterminal-(Anti-N)- und drei caboxylterminal-(Anti-C)-spezifischen Antiseren gemessen. Zwei Anti-C Seren und ein Anti-N-Serum erwiesen sich als geeignet zur Lokalisation der Nebenschilddrüsentumoren. Zusätzlich wurden die Parathormonfragmente durch Gelfiltration aufgetrennt, die Immunreaktivität in den Eluaten wurde mit Anti-N-und Anti-C-Seren bestimmt. Die Ergebnisse ließen erkennen, daß die Eignung der Antiseren zur Lokalisationsuntersuchung durch ihre Affinität für intaktes Hormon bestimmt wird, unabhängig von ihrer Anti-N-oder Anti-C-Eigenschaft.
    Notes: Summary Blood samples were obtained from 16 patients with primary or secondary hyperparathyroidism by selectively catheterising cervical and thyroid veins. Immunoreactive parathyroid hormone was measured with two aminoterminal (anti-N)- and three carboxyl-terminal (anti-C)-specific antisera. Two anti-C sera and one anti-N serum were useful in localising the parathyroid tumors. In addition, the parathyroid hormone fragments were separated by gelfiltration and the immunoreactivity in the effluent was estimated with anti-N and anti-C sera. The results suggest that the usefulness of antisera for parathyroid tissue localisation is determined by their affinity for the intact hormone, regardless of their anti-N or anti-C qualities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476665
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of digitoxin on cardiac arrhythmias in hemodialysis patients (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 1081-1086 
    Details
    ISSN: 1432-1440
    Keywords: Hemodialysis ; Digitoxin ; Arrhythmias
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Digitoxin is considered a risk factor for ventricular arrhythmias in hemodialysis patients. In a randomized, crossover controlled study, 55 hemodialysis outpatients with sinus rhythm were prospectively investigated in two 48-h periods of electrocardiographic monitoring, one on and one off digitoxin or vice versa. The frequency of ventricular ectopic beats (mean±SD) which were found in 31 of 55 patients (56%), was slightly higher on hemodialysis (10±28 beats/h) than in the following 20 h (5.4±10 beats/h) and the next day off hemodialysis (3.6±6.6 beats/h); however, no difference was seen in patients on digitoxin during hemodialysis (10±29 beats/h), in the following 20 h (4.8±15 beats/h) and on the next day off hemodialysis (1.2±6.6 beats/h). The frequency of ventricular bigemini, polymorphous ectopies, couplets, more than 30 ectopies/h, salvos and tachycardias (10 vs 9 patients) on and off digitoxin was about the same (n.s., Fisher test). Supraventricular bigemini, salvos, tachycardias, and atrial fibrillation, however, occurred in significantly fewer patients on digitoxin (3 vs 13) than in those off digitoxin (P=0.01, Fisher test). It is concluded that digitoxin does not increase the risk of ventricular arrhythmias in hemodialysis patients. Digitoxin, however, may have a beneficial effect on the supraventricular arrhythmias frequently observed in these patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01736114
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  • 4
    Electronic Resource
    Electronic Resource
    Elimination kinetics of plasma exchange (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 1115-1122 
    Details
    ISSN: 1432-1440
    Keywords: Plasma exchange ; Elimination kinetics ; Hybrid elimination rate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Interest in the therapeutic use of plasma exchange for various diseases is growing. The two different effects of plasma exchange are elimination and activation. The kinetics are linear for elimination by plasma exchange, but not for activation. Plasma exchange is performed intermittently and can be described by intermittent kinetics. According to intermittent kinetics, plasma exchange removes 50% to 75% of a substance in plasma within 1–2 h, corresponding to an elimination half-life of 30–40 min. Hybrid kinetics, a mixture of actually intermittent but theoretically continuous elimination by plasma exchange, can however also be applied. Hybrid kinetics are more convenient and more reliable than intermittent kinetics. This is because hybrid kinetics are based solely on the concentrations before each plasma exchange; hybrid kinetics also reflect removal from the entire body and not just from the plasma compartment. According to hybrid kinetics, the amount of a substance in the body removed within 3–4 days is 50% of the difference between the initial and the final plasma concentration, depending on the intensity of plasma exchange. The intensity may well contribute at least in part to the beneficial effect of plasma exchange in various diseases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01530838
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  • 5
    Electronic Resource
    Electronic Resource
    Einfluß der Vitamin-D3-Therapie auf die renale Osteodystrophie im Kindesalter (1980)
    Springer
    Journal of molecular medicine 58 (1980), S. 237-247 
    Details
    ISSN: 1432-1440
    Keywords: Child ; Renal osteodystrophy ; Vitamin D ; Kind ; renale Osteodystrophie ; Vitamin D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine Therapiestudie mit Vitamin D3 in pharmakologischen Dosen bei 27 Kindern in der progredienten Niereninsuffizienz bzw. unter intermittierender Dauerdialysebehandlung über 24 Monate zeigte, daß weder die Vitamin-D3-Behandlung unterstützt durch orale Calciumsupplementation alleine noch in Kombination mit Dialysebehandlung eine renale Osteodystrophie heilen oder verhindern kann. Es gelang zwar in 34,0% der Fälle mit progredienter Niereninsuffizienz und 50% der Fälle unter Hämodialysebehandlung den sekundären Hyperparathyreoidismus für einige Zeit zu suppremieren, eine Suppression auf Dauer konnte allerdings nicht erreicht werden. Das Ausmaß der Mineralisationsstörung und der Wachstumsverzögerung blieb unverändert, die Osteoblastenzahl erlitt mit Suppression des sekundären Hyperparathyreoidismus eine Reduktion, die eine Verminderung des Knochenanbaues und der Knochenmasse unter Dauertherapie mit Vitamin-D3 in pharmakologischen Dosen befürchten läßt. Hypercalcämien und extraossäre Verkalkungen wurden nicht beobachtet.
    Notes: Summary Growth arrest and renal osteodystrophy is a major problem in renal insufficiency of children. The present report describes our experiences in managing renal osteodystrophy by using vitamin D3 for 24 months. Values in plasma of Ca, Mg, alkaline phosphatase, iPTH, 25-OH-D were determined regularly. Skeletal X-rays and analysis of iliac crest bone biopsies were obtained in each child. In treatment with vitamin D3 no hypercalcemia was seen despite high serum levels of 25-OH-D. Plasma-Ca, alkaline phosphatase, and iPTH normalized nearly. Radiographic abnormalities improved. Bone biopsies showed improvement in signs of secondary hyperparathyroidism and ostitis fibrosa, whereas osteomalacia remained unchanged. Osteoblast population showed a small reduction. No real increment in body growth was seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01476970
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  • 6
    Electronic Resource
    Electronic Resource
    Einfluß von Diltiazem auf die Ciclosporin-Blutspiegel (1987)
    Springer
    Journal of molecular medicine 65 (1987), S. 1101-1103 
    Details
    ISSN: 1432-1440
    Keywords: Calcium channel blocking agents ; Ciclosporin-blood levels ; Kidney transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The simultaneous administration of the calcium channel blocker diltiazem and ciclosporin results in a significant increase of RIA ciclosporin blood levels. The HPLC ciclosporin levels are not influenced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01736117
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  • 7
    Electronic Resource
    Electronic Resource
    Osteomalacia of the mother —rickets of the newborn (1987)
    Springer
    European journal of pediatrics 146 (1987), S. 292-293 
    Details
    ISSN: 1432-1076
    Keywords: Osteomalacia ; Neonatal rickets ; 25-hydroxy-vitamin D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract During the last 4 years we observed four cases of neonatal rickets. The mothers of the infants suffered from osteomalacia for 1–3 years prior to its diagnosis shortly after the birth of their children. All four infants were born with craniotabes, and one infant had, in addition, a radial fracture. The diagnoses were confirmed by radiological and laboratory tests which revealed a rarefied bone structure, decreased serum 25-hydroxy-vitamin D and increased alkaline phosphatase levels in all patients. The disorder regressed under low-dose vitamin D3 therapy. As osteomalacia seems to be predominant in oriental women living in Berlin, it is necessary to consider vitamin D deficiency when clinical symptoms of this disease arise and to treat these women at least during pregnancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00716477
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  • 8
    Electronic Resource
    Electronic Resource
    Cyclosporin drug monitoring: Comparison of four immunoassays and HPLC (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 438-441 
    Details
    ISSN: 1432-1440
    Keywords: Cyclosporin ; Drug monitoring ; Immunoassay ; High-performance liquid chromatography ; Renal transplantation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Cyclosporin blood trough levels were measured with four different immunoassays and high-performance liquid chromatography in 12 patients receiving low-dose steroids and CsA after kidney transplantation. These patients represent a selection with an uncomplicated posttransplant course and received no drugs with a known influence on CsA pharmacokinetics. The use of specific antibodies against the parent drug yielded levels comparable to those detected by HPLC. CsA levels measured with nonspecific antibodies exceeded those measured with specific ones by a factor of two to three. All immunoassay-detected CsA levels correlated significantly with the HPLC-determined CsA levels. In addition, blood levels of the CsA metabolites 1, 17, 18, and 21 were determined by HPLC. In one additional patient, who was under tuberculostatic treatment and had a transitory deterioration of liver function, levels of nonspecificantibody-determined CsA rose, as confirmed by rising levels of metabolite 17, while those of the parent drug fell. We conclude that routine drug monitoring should include at least one immunoassay with a specific antibody detecting the unchanged CsA, and a supplementary immunoassay with a nonspecific antibody detecting a composition of cross-reacting metabolites plus the unchanged substance. If available, HPLC should be used to confirm levels of CsA and its metabolites in patients with suspected alteration of their CsA metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01725139
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  • 9
    Electronic Resource
    Electronic Resource
    Vorteile und Risiken der Nierentransplantation von verwandten spendern (1989)
    Springer
    Journal of molecular medicine 67 (1989), S. 929-935 
    Details
    ISSN: 1432-1440
    Keywords: Kidney transplantation ; Living related kidney transplantation ; Graft function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Living related kidney transplantation must offer the recipient distinct advantages over cadaveric grafting in order to justify the health risk undertaken by the donor. At Steglitz Medical Center in Berlin from 1970 to 1987 30 such transplantations were performed (5% of all kidney transplantations) where the donor was a relative of the recipient. In cases of haploidentity and positive mixed lymphocyte culture, the recipients were pretreated with donor-specific transfusions. The posttransplantation graft function rate was higher in the group where the donated kidney came from a relative than where it did not (after 2 years under cyclosporin: 92% vs 73%,P=0.04), and corticosteroid treatment could be terminated more frequently under cyclosporin (95% vs 51%,P=0.001). Transplantations from living related donors were performed more often in foreigners (43% vs 20%,P=0.01) and children (19% vs 4%,P=0.0001). Perioperative complications in the donor nephrectomy occurred in 63% of the cases, severe ones in 13% (bleeding, pneumonia, and late abscess). Late sequelae were not observed. The short waiting time, the high graft function rate, and the low steroid requirement justify kidney transplantation from living related donors providing strict indicational criteria are observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01721418
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  • 10
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of 5,6-trans-25-hydroxycholecalciferol, a synthetic analogue of vitamin D3, in man (1975)
    Springer
    European journal of clinical pharmacology 8 (1975), S. 255-260 
    Details
    ISSN: 1432-1041
    Keywords: Vitamin D ; renal osteodystrophy ; 5,6-trans-25-hydroxycholecalciferol ; rickets ; pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Vitamin D analogues of high biological activity are probably useful in the treatment of renal osteodystrophy. The pharmacokinetics of the synthetic compound 5,6-trans-25-hydroxycholecalciferol have been studied in healthy subjects who were of normal vitamin D status. In comparison to natural 25-hydroxy-cholecalciferol, serum levels of the analogue were lower and its half-life in blood after oral or intravenous administration was considerably shorter. In normal subjects no increase of dihydroxylated metabolites in serum was observed within seven days of an intravenous dose.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00567124
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