ISSN:
1432-2277
Keywords:
Steroid withdrawal, kidney transplantation
;
Kidney transplantation, steroid withdrawal
;
Conversion, steroid to azathioprine, kidney transplantation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The long-term graft function after withdrawal of steroids from maintenance immunosuppression was analyzed in 98 kidney recipients (59 on cyclosporin monotherapy, 39 on cycloporin plus azathioprine) who had not developed an early rejection episode when prednisolone was discontinued. Seven years after steroid withdrawal the probability of an increase in serum creatinine (〉20% of baseline levels) was 51%. The increase in creatinine was associated with sclerosing arteriopathy as a marker of chronic rejection in 29 of 43 graft biopsies. The addition of azathioprine had no, effect on the stability of long-term graft function and did not influence the 7-year graft survival rate in this highly selected group of patients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00336030
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