ISSN:
1432-1041
Keywords:
Rifampicin
;
plasma protein binding
;
isoniazid
;
p-aminosalicylic acid
;
streptomycin
;
ethambutol
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The binding of rifampicin to human plasma proteins has been investigated by equilibrium dialysis. Plasma from eleven healthy subjects not taking drugs bound 87–91% of added rifampicin. Binding was lower (84–88%) in plasma from ten tuberculous patients on long-term treatment with rifampicin. Physiological concentrations of human albumin, gamma globulin and fibrinogen bound 41, 10 and 8%, respectively, of added rifampicin. Isoniazid, p-aminosalicylic acid, streptomycin and ethambutol did not significantly affect rifampicin binding to plasma proteins.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00558209
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