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  • 1
    Electronic Resource
    Electronic Resource
    The Light Green Cells ofLymnaea: A neuroendocrine model system for stimulus-induced expression of multiple peptide genes in a single cell type (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 464-473 
    Details
    ISSN: 1420-9071
    Keywords: Molluscan insulin-related peptides ; schistosomin ; neuropeptide gene family ; generation of neuropeptide diversity ; stimulus-dependent expression ; information-handling capacity ; evolution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We review recent experiments showing that the cerebral neuroendocrine Light Green Cells (LGCs) of the freshwater snail,Lymnaea stagnalis, express a family of distinct though related molluscan insulin-related peptide (MIP) genes. The LGCs are involved in the regulation of a wide range of interrelated life processes associated with growth, (energy) metabolism and reproduction. We consider the mechanism of generation of diversity among MIPs, and present evidence that conditions with distinct effects on growth, metabolism and reproduction also can induce distinct patterns of expression of the MIP and schistosomin genes. The stimulus-dependent expression of multiple neuropeptide genes enormously increases the adaptive potential of a peptidergic neuron. We suggest that this contributes significantly to the information-handling capacity of the brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01928165
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Alternative splicing generates diversity of VD1/RPD2α peptides in the central nervous system ofLymnaea stagnalis (1993)
    Springer
    Cellular and molecular neurobiology 13 (1993), S. 123-136 
    Details
    ISSN: 1573-6830
    Keywords: VD1/RPD2α peptides ; alternative mRNA splicing ; organization of VD1/RPD2 gene ; cDNA cloning ; polymerase chain reaction ; molluskLymnaea stagnalis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. Two giant peptidergic neurons, VD1 and RPD2, of the visceral ganglion and right parietal ganglion ofLymnaea stagnalis, respectively, play an important role in the modulation of complex physiological and behavioral adjustments that occur as a result of changes in O2 availability. 2. By cDNA cloning, we have identified two types of VD1/RPD2 transcripts expressed in VD1 and RPD2. In addition, these transcripts are also expressed in other neurons. 3. Both transcripts encode distinct yet related VD1/RPD2 preprohormones that may be cleaved to yield distinct but overlapping sets of neuropeptides. 4. Using the polymerase chain reaction technique, we could show the existence of additional splice variants. 5. Analysis of the organization of the VD1/RPD2 gene indicates that theα peptide coding region is interrupted by a number of introns. 6. We concluded that the mRNA segment encoding theα peptide domain of the VD1/RPD2 preprohormones is alternatively spliced, thus generating differentα peptides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00735369
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    Paper (German National Licenses)
    Fulltext
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