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  • 1
    Electronic Resource
    Electronic Resource
    A pharmacological analysis of prostaglandin E1 on portal blood flow after partial hepatectomy in rats (1993)
    Springer
    Surgery today 23 (1993), S. 277-279 
    Details
    ISSN: 1436-2813
    Keywords: prostaglandin E1 ; hepatectomy ; portal venous flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Portal venous flow (PVF) and portal venous pressure (PVP) were examined after the jugular or portal injection of Prostaglandin E1 (PGE) in rats partially hepatectomized by either 40% or 66%. In the 66% hepatectomized animals, the jugular injection of PGE at 5.0 μg/kg/min produced an increase in PVF concomitant with a fall in systemic arterial pressure (SAP), while PVP remained unchanged. The portal injection of PGE at 0.5 μg/kg/min increased PVF to a level equivalent to that evoked by the jugular injection of 5.0 μg/kg/min PGE, without any change in SAP. PVP was reduced synchronistically with an increase in PVF. The PVF response to a portal injection of PGE at 0.5 μg/kg/min was not reproduced in liver intact rats. These results suggest that PGE is potent in increasing PVF in the partially resected condition of the liver and that the portal vascular bed is involved in this response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00309242
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Enhancement of portal blood flow by ursodesoxycholic acid in partially hepatectomized rats (1996)
    Springer
    Surgery today 26 (1996), S. 142-144 
    Details
    ISSN: 1436-2813
    Keywords: ursodesoxycholic acid ; portal venous flow ; hepatectomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Portal venous flow (PVF) was examined after portal injection of ursodesoxycholic acid (URSO) in rats that were partially hepatectomized by either 40% or 66%. URSO (10 mg/kg per minute) was injected into the portal vein and was thereafter observed to increase PVF concomitantly with a fall in portal venous pressure (PVP) in control animals. The increase in PVF in response to URSO was dose-dependent. In hepatectomized rats, the PVF response was augmented when the same dose of URSO was portally injected, and the magnitude of response was enhanced in proportion to the volume of liver resected. These results suggest that URSO increases PVF through vasodilation of the portal vessels, and therefore URSO is considered to increase PVF potently in a partially hepatectomized condition.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00311781
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Role of shear stress and immune responses in liver regeneration after a partial hepatectomy (1999)
    Springer
    Surgery today 29 (1999), S. 1-9 
    Details
    ISSN: 1436-2813
    Keywords: Liver regeneration ; shear stress ; immunity ; major histocompatibility complex ; sieve plates ; space of Disse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract This report reviews studies addressing the new concepts in liver regeneration after a partial hepatectomy (PHx). The review begins with an overview of the immunologic mechanisms of liver regeneration after PHx, especially regarding Kupffer cells and extrathymic T cells of the regenerative liver in the cell-mediated immunity, based on major histocompatibility complex I and II antigens. Attention is then devoted to “on and off” studies in liver regeneration after PHx, by hypothesizing the shear stress based on the fact that the portal flow against hepatocytes or sinusoidal endothelial cells triggers their regeneration after a partial hepatectomy and controls the volume of the regenerating liver by the stimulating the cell surface modulator (CSM) of hepatocytes and sinusoidal endothelial cells (SEC). We propose that the acute elevation of shear stress after PHx influences the adhesion between SEC and intrahepatic leukocytes. These concepts are expected to positively contribute to the future research on liver regeneration after PHx.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02482962
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Role of Shear Stress and Immune Responses in Liver Regeneration After a Partial Hepatectomy (1999)
    Springer
    Surgery today 29 (1999), S. 1-9 
    Details
    ISSN: 1436-2813
    Keywords: Key Words: Liver regeneration ; shear stress ; immunity ; major histocompatibility complex ; sieve plates ; space of Disse
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s005950050348
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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