ISSN:
1420-9071
Keywords:
Angiogenesis
;
diabetes
;
mast cells
;
mesentery
;
quantification
;
rat
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Rats with streptozotocin-induced diabetes mellitus showed a 3.4–4.5 times increased angiogenic response following mast-cell activation in situ as compared with age-matched normal controls. The test tissue used was the mesenteric window, which we have previously exploited as a quantitative angiogenesis assay. In the present study two idependent techniques for quantifying the angiogenic response showed essentially the same result. The finding of a pathologically increased angiogenic reaction in the diabetic animals is noteworthy since some of the most harmful complications of diabetes in man relate to proliferative vascular lesions.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01935538
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