ISSN:
1420-9071
Keywords:
Anoxic injury
;
mitochondrial respiration
;
renal medulla
;
acute renal failure
;
renal metabolism
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary In brain1, heart2 and kidney3, cell work in the absence of oxygen has been thought to precipitate anoxic damage by increasing the rate of depletion of cellular energy stores. In the medullary thick ascending limb of isolated perfused rat kidneys, however, reduction of ATP synthesis by a variety of mitochondrial or metabolic inhibitors caused ATP depletion comparable to that produced by oxygen deprivation but did not reproduce the lesions of anoxia. In these cells, unrestrained mitochondrial activity may be an important source of anoxic injury.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01946708
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