ISSN:
1573-2622
Schlagwort(e):
amacrine cells
;
dopamine
;
electroretinogram
;
MPTP
;
oscillatory potentials
;
retina
;
rhesus monkey
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Medizin
Notizen:
Abstract We have investigated the functional role of dopamine in the monkey retina by recording the retinal responses to flash stimulations before and after destruction of dopaminergic cells by intravenous injection of N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). We evaluated specifically the oscillatory potentials (100 Hz-3KHz) of the electroretinogram. By day 47 after MPTP injection, a selective decrease of the amplitude of the first oscillatory potential was observed. At that time the animals had been receiving antiparkinsonian therapy since day 15. These results suggest that retinal dopaminergic neurons may play a role in the generation of the first oscillatory potential, and moreover, that each oscillatory potential should be considered individually.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00143954
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