ISSN:
1573-2622
Keywords:
amacrine cells
;
dopamine
;
electroretinogram
;
MPTP
;
oscillatory potentials
;
retina
;
rhesus monkey
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract We have investigated the functional role of dopamine in the monkey retina by recording the retinal responses to flash stimulations before and after destruction of dopaminergic cells by intravenous injection of N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP). We evaluated specifically the oscillatory potentials (100 Hz-3KHz) of the electroretinogram. By day 47 after MPTP injection, a selective decrease of the amplitude of the first oscillatory potential was observed. At that time the animals had been receiving antiparkinsonian therapy since day 15. These results suggest that retinal dopaminergic neurons may play a role in the generation of the first oscillatory potential, and moreover, that each oscillatory potential should be considered individually.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00143954
