ISSN:
1435-1463
Keywords:
Pineal extracts
;
human melanoma cells
;
growth-inhibiting effect
;
synthetic pineal compounds and analogues
;
in vitro experiments
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The effect was studied of a number of synthetic indoleamines, pteridines,β-carbolines, of AVT and of crude extracts from rat and ovine pineal glands on human melanoma cellsin vitro. The identified pineal substances as well as some of their analogues showed an inhibitory effect only at non-physiologically high concentrations. However, crude pineal extracts were more active than the synthetic pineal substances tested. They contain a compound which may have a tumor-inhibiting potency comparable to that of methotrexate but a different mechanism of action.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01244350
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