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  • 1
    Digitale Medien
    Digitale Medien
    Cognitive impairment in systemic lupus erythematosus: a follow-up study (2000)
    Springer
    Journal of neurology 247 (2000), S. 273-279 
    Details
    ISSN: 1432-1459
    Schlagwort(e): Key words Systemic lupus ¶erythematosus ; Neuropsychiatric ¶lupus ; Cognitive impairment
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We evaluated outcome and the clinical value of cognitive impairment in systemic lupus erythematosus (SLE). Fifty-one consecutive SLE subjects with or without overt nervous system involvement received two comprehensive neuropsychiatric and neuropsychological assessments, including the Mental Deterioration Battery, the Mini Mental State Examination (MMSE), and tests from the Wechsler Adult Intelligence Scale. The two neuropsychological assessments were made when subjects were in stable neurological condition. Twenty-seven patients were found to have neuropsychiatric symptoms (NP-SLE) at the first assessment, and three others developed them during the follow-up. Fifteen patients (10 NP-SLE) had cognitive impairment at the first assessment. At retest the cognitive deficit persisted in all patients but one (non-NP-SLE) and had developed in four others. In the cognitively impaired subjects scores on MMSE approached the cutoff for an overt dementing condition. No progressively decreasing scores were found on any of the tests. No relationships were shown between neuropsychological diagnosis and neuropsychiatric disorder, neuroradiological findings, disease activity, or steroid and nonsteroid immunosuppressive therapy. Cognitive impairment thus seems to be a stable symptom of CNS involvement in SLE. It corresponds to the subjective complaint of intellectual difficulties and marginal performance on the MMSE. Intellectual deterioration may occur in patients without other symptoms of NP-SLE. Standardized neuropsychological testing methods should be used routinely to assess SLE patients.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s004150050583
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  • 2
    Digitale Medien
    Digitale Medien
    A case of diffuse lupus encephalopathy successfully treated with high-dose intravenous methylprednisolone (1992)
    Springer
    Neurological sciences 13 (1992), S. 247-250 
    Details
    ISSN: 1590-3478
    Schlagwort(e): Encephalopathy ; systemic lupus erythematosus ; pulse therapy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Beschreibung / Inhaltsverzeichnis: Sommario Viene descritto il caso di una giovane donna affetta da Lupus eritematoso sistemico (LES) che, dopo l'interruzione spontanea della terapia corticosteroidea orale in occasione della sua prima gravidanza esitata in aborto, presenta una grave encefalopatia con insufficienza respiratoria e coma. La somministrazione di alte dosi di metilprednisolone per via endovenosa (“pulse therapy”) determina una rapida e completa risoluzione della sintomatologia. Questo caso suggerisce l'utilità di questo tipo di trattamento nelle manifestazioni neurologiche acute e gravi in corso di LES.
    Notizen: Abstract We report a case of systemic lupus erythematosus (SLE) in a young woman who presented a serious encephalopathy with respiratory distress and coma, after arbitrary interruption of oral corticosteroid therapy when her first pregnancy ended in abortion. The patient showed rapid improvement on methylprednisolone pulse therapy. The case suggests the utility of such a therapy in severe, non focal, CNS complications of SLE.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02224397
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  • 3
    Digitale Medien
    Digitale Medien
    Clinical setting of patients with systemic sclerosis by serum autoantibodies (1997)
    Springer
    Clinical rheumatology 16 (1997), S. 378-383 
    Details
    ISSN: 1434-9949
    Schlagwort(e): Systemic Sclerosis ; Antinuclear Antibodies ; Anticentromere Antibodies ; Anticardiolipin Antibodies ; Antiphospholipid Antibodies ; Disease Score of Systemic Sclerosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Associations of antinuclear (ANA) and anticardiolipin (aCL) antibodies with clinical manifestations were analyzed in patients with systemic sclerosis (SSc). We studied 105 SSc patients: 28 had limited cutaneous SSc (IcSSc) involving fingers; 36 had intermediate cutaneous SSc involving limbs and face; 33 had diffuse cutaneous SSc (dcSSc) involving the trunk; 8 had a sclerosis sine scleroderma. Clinical manifestations and instrumental and laboratory findings were considered to calculate a disease score. Serum anticentromere (ACA), anti-topoisomerase I (anti-topo I) antibodies, and aCL (of IgG/IgA/IgM classes) were investigated by conventional methods. ACA positive patients (n=18), compared to ACA negative, showed higher prevalence of IcSSc (p 〈 0.001), lower prevalence of restrictive ventilatory defect (p=0.006), and lower disease score (p=0.008). Anti-topo I positive patients (n=70) showed lower prevalence of IcSSc (p=0.001) compared to anti-topo I negative. In aCL positive patients (n=27) widespread skin and visceral involvement occurred more frequently than in aCL negative. The association with myocardial ischemia or necrosis (p=0.010) was significant. Occurrence of ACA excluded the coexistence of anti-topo I (p〈0.001), and aCL (p=0.037). aCL positive patients showed higher disease score in comparison with ACA positive patients (p=0.003). In conclusion ACA recognize patients with a mild disease. aCL in contrast to ACA are better than anti-topo I in recognizing the most severe pictures of SSc.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02242455
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  • 4
    Digitale Medien
    Digitale Medien
    Adult polyomyositis/dermatomyositis associated with acute myeloid leukemia. A case report (1995)
    Springer
    Clinical rheumatology 14 (1995), S. 217-219 
    Details
    ISSN: 1434-9949
    Schlagwort(e): Polymyositis/Dermatomyositis ; Acute Myeloid Leukemia ; Malignancy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary Reports of PM/DM associated with haematologic disorders are rare. We describe a 62-year-old man suffering from PM/DM who developed acute myeloid leukemia. The possible paraneoplastic nature of PM/DM in this patient is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02214948
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  • 5
    Digitale Medien
    Digitale Medien
    Infective endocarditis presenting as polyarthritis (1998)
    Springer
    Clinical rheumatology 17 (1998), S. 518-520 
    Details
    ISSN: 1434-9949
    Schlagwort(e): Febrile polyarthritis ; Infective endocarditis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract We report the case of a patient who complained of arthralgias and arthritis 1 month before the onset of fever or other signs of infective endocarditis. In 2 months she developed an additive, asymmetrical polyarthritis with fever (febrile polyarthritis). Splenomegaly was present. Two-dimensional echocardiography showed no vegetations or other findings suggesting endocardial involvement. Initially, four blood cultures showed no microorganisms, then six of nine subsequent blood cultures grew highly gentamicin-resistantEnterococcus faecalis.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01451291
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