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  • 1
    Electronic Resource
    Electronic Resource
    Cognitive impairment in systemic lupus erythematosus: a follow-up study (2000)
    Springer
    Journal of neurology 247 (2000), S. 273-279 
    Details
    ISSN: 1432-1459
    Keywords: Key words Systemic lupus ¶erythematosus ; Neuropsychiatric ¶lupus ; Cognitive impairment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated outcome and the clinical value of cognitive impairment in systemic lupus erythematosus (SLE). Fifty-one consecutive SLE subjects with or without overt nervous system involvement received two comprehensive neuropsychiatric and neuropsychological assessments, including the Mental Deterioration Battery, the Mini Mental State Examination (MMSE), and tests from the Wechsler Adult Intelligence Scale. The two neuropsychological assessments were made when subjects were in stable neurological condition. Twenty-seven patients were found to have neuropsychiatric symptoms (NP-SLE) at the first assessment, and three others developed them during the follow-up. Fifteen patients (10 NP-SLE) had cognitive impairment at the first assessment. At retest the cognitive deficit persisted in all patients but one (non-NP-SLE) and had developed in four others. In the cognitively impaired subjects scores on MMSE approached the cutoff for an overt dementing condition. No progressively decreasing scores were found on any of the tests. No relationships were shown between neuropsychological diagnosis and neuropsychiatric disorder, neuroradiological findings, disease activity, or steroid and nonsteroid immunosuppressive therapy. Cognitive impairment thus seems to be a stable symptom of CNS involvement in SLE. It corresponds to the subjective complaint of intellectual difficulties and marginal performance on the MMSE. Intellectual deterioration may occur in patients without other symptoms of NP-SLE. Standardized neuropsychological testing methods should be used routinely to assess SLE patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004150050583
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  • 2
    Electronic Resource
    Electronic Resource
    Hyaluronic acid: analytical procedures for purity determination, polymerization degrees and comparative instrumental test ‘in vivo’ (1989)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of cosmetic science 11 (1989), S. 0 
    Details
    ISSN: 1468-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Recent studies have shown that hyaluronic acid is an important molecule in cosmetics, although there are different, sometimes controversial theories about its role.This work is an analytical contribution to the characterization and control of hyaluronic acid. The main techniques used are UV, GCP or SEC, IR and corneometry.Surveys conducted with the aid of these techniques have allowed a better knowledge of the molecular weight determination and of the uniform quality of commercial supplies.These procedures may be of application for quality control and promote further investigation on the biological tissular role played by hyaluronic acid in topical cosmetic products.The analytical results of a study of the evaluation of oil/water (o/w) emulsions containing hyaluronic acid of different origins are reported. The analytical data obtained from cutaneous hydration control apparatuses were compared statistically.The choice of hyaluronic acid, made through screening and evaluation by the abovementioned techniques, ensures the optimal formulation of the finished product and a quality standard of the active principle.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-2494.1989.tb00498.x
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  • 3
    Electronic Resource
    Electronic Resource
    Thermal Analysis of the Freezing of Ice Cream Brickettes by the Finite Element Method (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 50 (1985), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: An unsteady-state theoretical analysis of the cooling of a large cross-section ice cream brickette is presented, to model the hardening process required for handling and storage purposes. The material physical properties, i.e. heat conductivity and thermal capacity, are considered temperature dependent, according to available experimental data on a vanilla ice cream. The material is assumed to be macroscopically homogeneous, in the sense that the phase change is simulated by adoption of effective physical properties. The bidimensional differential equations governing the process have been solved numerically using the finite element method, which is extremely powerful for defining optimal design criteria and process control strategies. Results are presented and discussed for different external heat transfer conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1985.tb10500.x
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  • 4
    Electronic Resource
    Electronic Resource
    Analysis of trace amounts of dichloromethane in polycarbonates
    Amsterdam : Elsevier
    Journal of Chromatography A 152 (1976), S. 538-541 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(00)85095-5
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  • 5
    Electronic Resource
    Electronic Resource
    Gas chromatographic head-space determination of residual acrylonitrile in acrylonitrile-butadiene-styrene resins and migration into a simulated fatty foodstuffs liquid
    Amsterdam : Elsevier
    Journal of Chromatography A 160 (1978), S. 133-140 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(00)91789-8
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  • 6
    Electronic Resource
    Electronic Resource
    Improvement of chronic idiopathic urticaria with l-thyroxine: a new TSH role in immune response? (2005)
    Oxford, UK : Munksgaard International Publishers
    Allergy 60 (2005), S. 0 
    Details
    ISSN: 1398-9995
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  The association between chronic idiopathic urticaria (CIU) and autoimmune thyroiditis (AT) is known, as well as major prevalence of antithyroid antibodies in the allergical subjects and other autoimmune diseases. We have evaluated the effects of l-thyroxine on clinical symptoms of CIU in AT patients suggesting the hypothesis of a new thyroid-stimulating hormone (TSH) role in immune system.Methods:  In 20 female patients with CIU + AT, both hypothyroid and euthyroid, we have investigated the therapeutic effects of l-thyroxine dosed to suppress the TSH. Free-T3, Free-T4, TSH, antithyroperoxidase and antithyroglobulin antibodies, total immunoglobulin (Ig)E, Rheuma test and eritro-sedimentation rate were monitored during treatment.Results:  In 16 patients a strong decrease of urticaria symptoms has happened after 12 weeks. The TPO Ab and HTG Ab clearly decreased in 14 patients. Furthermore, in two patients with rheumatoid arthritis and in two patients with pollen allergy a strong decrease of rheuma test titer and total IgE has happened.Conclusion:  The reason of AT is associated to CIU and others allergical and autoimmune diseases is poorly known. The exclusive hormonal therapy reduces the symptoms of CIU and inflammatory response in many chronic diseases associated to AT. We suggest a stimulatory effect of TSH able to produce considerable changes of the immune response and immune tolerance in patients with AT causing target organs damage.The causal mechanism involves immune, nervous and endocrine system, sharing a common set of hormones, cytokines and receptors, in a unique totally integrated loop (the neuro–immuno–endocrine axis).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1398-9995.2005.00723.x
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  • 7
    Electronic Resource
    Electronic Resource
    CHARACTERIZATION AND CONTROL OF AN IMMOBILIZED ALLOSTERIC ENZYME SYSTEM (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 369 (1981), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1981.tb14191.x
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  • 8
    Electronic Resource
    Electronic Resource
    Characterization of an Enzymatic Capillary Membrane Reactor (1984)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 434 (1984), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1984.tb29812.x
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  • 9
    Electronic Resource
    Electronic Resource
    A case of diffuse lupus encephalopathy successfully treated with high-dose intravenous methylprednisolone (1992)
    Springer
    Neurological sciences 13 (1992), S. 247-250 
    Details
    ISSN: 1590-3478
    Keywords: Encephalopathy ; systemic lupus erythematosus ; pulse therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Viene descritto il caso di una giovane donna affetta da Lupus eritematoso sistemico (LES) che, dopo l'interruzione spontanea della terapia corticosteroidea orale in occasione della sua prima gravidanza esitata in aborto, presenta una grave encefalopatia con insufficienza respiratoria e coma. La somministrazione di alte dosi di metilprednisolone per via endovenosa (“pulse therapy”) determina una rapida e completa risoluzione della sintomatologia. Questo caso suggerisce l'utilità di questo tipo di trattamento nelle manifestazioni neurologiche acute e gravi in corso di LES.
    Notes: Abstract We report a case of systemic lupus erythematosus (SLE) in a young woman who presented a serious encephalopathy with respiratory distress and coma, after arbitrary interruption of oral corticosteroid therapy when her first pregnancy ended in abortion. The patient showed rapid improvement on methylprednisolone pulse therapy. The case suggests the utility of such a therapy in severe, non focal, CNS complications of SLE.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02224397
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  • 10
    Electronic Resource
    Electronic Resource
    Familial amyloidotic polyneuropathy: Description of an Italian kindred (1993)
    Springer
    Neurological sciences 14 (1993), S. 303-309 
    Details
    ISSN: 1590-3478
    Keywords: Polyneuropathy ; amyloidosis ; transthyretin (TTR)
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Sommario Le Polineuropatie Amiloidosiche Familiari (FAP) sono un gruppo eterogeneo di affezioni trasmesse in via autosomica dominante caratterizzate dalla deposizione sistemica di fibrille amiloidi e dall'interessamento preminente del Sistema Nervoso Periferico (SNP). Queste affezioni, descritte frequentemente in vari gruppi etnici, sono state raramente segnalate in Italia. L'osservazione di un 42enne, venuto alla nostra osservazione per una perdita della sensibilità termo-dolorifica agli arti inferiori, ci ha consentito l'identificazione di una estesa famiglia italiana con 19 membri affetti da FAP. La diagnosi era basata su dati clinico-strumentali in 8 soggetti e su notizie anacatamnestiche in altri 11. Nella famiglia da noi studiata la malattia esordisce tra i 35 e i 50 anni di età e il decorso è progressivo e spesso fatale. L'esordio è contrassegnato dai sintomi disautonomici e neuropatici. La compromissione cardiaca e renale è frequente ed è spesso causa di morte.
    Notes: Abstract Familial amyloidotic polyneuropathy (FAP) is a heterogeneous group of genetic disorders characterized by progressive systemic deposition of extracellular amyloid fibrils, mainly affecting the peripheral nervous system (PNS). These disorders, inherited as an autosomal dominant trait, have frequently been described in various ethnic groups, but have rarely been reported in Italy. A 42 year-old man came to our observation for loss of pain and temperature sense in his legs. Clinical and laboratory data pointed to an amyloidotic polyneuropathy. This led us to discover a large italian kindred in which 19 members were affected by FAP. The diagnosis, established in 8 members on the clinical and laboratory findings, was ana-catamnestic in other 11. In this kindred the onset of the disease ranges from 35 to 50 years of age and the course is progressive and often fatal. The early symptoms are mainly related to autonomic disturbances and to peripheral neuropathy. Cardiac and renal involvement occurs frequently and may be life-threatening.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02339296
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