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  • 11
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 77 (2000), S. 1366-1368 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We present error rate simulations for a single flux quantum logic circuit which include statistical variations in the circuit parameters. We find that the fabrication yield, junction critical margins, and bit error probabilities of the nominal circuit can give a false impression of the performance of practical circuits. For our study circuit, the toggle flipflop, we find that, although the standard figures of merit may vary only marginally with design rules, the average error rate can differ by a factor of 104. Furthermore, for a state-of-the-art technology, the error rates of different realizations of the same design actually span 10 orders of magnitude. These results highlight the inadequacy of current figures of merit to gauge the performance of high temperature superconductor designs. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 60 (1992), S. 2433-2435 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Josephson junctions have been made by the evaporation of epitaxial YBa2Cu3O7 over steps etched in (001) MgO. Such junctions differ from those grown on perovskite substrates in that the c-axis of the film grows approximately normal to the local substrate surface, so the junction comprises two tilt grain boundaries. Results are reported for junctions formed by this process which showed Josephson currents at temperatures up to 89 K and resistively shunted junctionlike current-voltage curves. A weak magnetic field applied normal to the substrate gave Fraunhofer patterns indicative of good current uniformity across the junction. The dc SQUIDs show deep modulation, and promising noise performance.
    Type of Medium: Electronic Resource
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  • 13
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 64 (1994), S. 366-368 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Epitaxial thin-film YBa2Cu3O7 flux transformers with multiturn input coils have been constructed on 1 cm2 MgO substrates using PrBa2Cu3O7 as an insulator. By coupling these to high-temperature superconducting quantum interference devices (SQUIDs) using a flip-chip technology, several low-noise magnetometers and a gradiometer have been constructed. The yield of fully working flux transformers on 1 cm2 substrates exceeds 80%, and field sensitivities at 77 K of (520±30)fT/(square root of)Hz at 1 Hz and (165±8)fT/(square root of)Hz above 10 Hz have been achieved. No evidence for excess low-frequency noise above that of the uncoupled SQUID has been found in the flip-chip magnetometers.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 61 (1992), S. 228-230 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: In the processing of high temperature superconductor thin films into devices, the use of calibrated milling rates has proved unreliable as a means of determining the milled depth. This problem has been solved using in situ secondary ion mass spectrometry for identifying interfaces in multilayers based on YBa2Cu3O7. The depth resolution obtained during routine patterning of typical multilayers was ∼4 nm. Accurate termination of milling at an insulator/superconductor interface has been demonstrated. The presence of water vapor during milling has been shown to affect the proportions of the different secondary ion species, but has only a slight affect on the milling rate.
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 64 (1994), S. 918-920 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Current flow in YBa2Cu3O7/PrBa2Cu3O7 multilayer structures has been studied using low temperature, scanning electron microscope, beam-induced voltage contrast. Specialized data acquisition has been used to limit thermalization effects and improve resolution. For both via hole contacts and crossovers, the lowest critical current densities were found at steps where the superconductor tracks climb up or down over patterned edges of the insulator.
    Type of Medium: Electronic Resource
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  • 16
    Electronic Resource
    Electronic Resource
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 60 (1992), S. 1516-1518 
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A low-temperature argon ion milling process has been used to induce growth of c-oriented YBa2Cu3O7 on (001) MgO substrates with the in-plane film axes rotated 45° with respect to those of the substrate, and with respect to those of films grown on untreated regions of the substrate. This process is compatible with standard photolithographic processing, and has been used to produce defined areas of the two orientations on the same substrate. Josephson junctions and dc SQUIDs have been fabricated using the resulting grain boundaries.
    Type of Medium: Electronic Resource
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  • 17
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The study of the immunobiology of FVIII inhibitors may lead to new therapies for this potentially severe complication of haemophilia A and to new principles for the use of therapeutic proteins. In order to characterize the idiotype-anti-idiotype networks regulating FVIII inhibitors, we developed rabbit antiidiotypic sera to 7 murine inhibitors and found at least 12 independent FVIII loci to which inhibitors could be raised. Rabbit antisera to the FVIII peptide. Ser1687-Thr1695 characterized one functional site to which about 46% of patients' inhibitor sera reacted. The multiplicity of inhibitor-recognized epitopes in FVIII makes it impractical, at the present time, to develop clinically useful specific anti-idiotypic therapies for FVIII inhibitors. Alternatively, one might induce genomic mutations in recombinant FVIII molecules to decrease immunogenicity of epitopes recognized by T helper cells. Methods to design such altered therapeutic proteins are presented, based on changing the longitudinal hydrophobic strip of-helix which is in or near many T-cell-presented epitopes.
    Type of Medium: Electronic Resource
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  • 18
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 101 (1979), S. 2743-2744 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 19
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Industrial & engineering chemistry 7 (1915), S. 269-269 
    ISSN: 1520-5045
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Scandinavian journal of immunology 54 (2001), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The discovery of the interactions of the ‘Ii-Key’ segment of the Ii protein with the major histocmpatibility complex (MHC) Class II allosteric site, which is adjacent to the antigenic peptide-binding site, creates therapeutic opportunities by regulating the antigenic peptide binding to MHC class II molecules. The binding of Ii-Key to the MHC class II allosteric site loosens the hold of the MHC Class II ‘clamshell’ on antigenic peptides and leads to highly efficient antigenic peptide charging to or releasing from the MHC class II antigenic peptide-binding groove. Ii-Key peptide-induced spilling of bound antigenic peptide, or replacement with inert blockers, leads to ‘inert immunosuppression’. Highly efficient replacement of ambient with vaccine peptides by Ii-Key permits ‘active immunosuppression’ for antigen-specific control of autoimmune diseases in the absence of cytokines or adjuvants. On the other hand, active immunization against cancer or infectious disease can result from epitope replacement mediated by Ii-Key and accompanied by cytokines or other adjuvants. Finally, linking the Ii-Key peptide through a simple polymethylene bridge to an antigenic sequence vastly increases the potency of MHC Class II peptide vaccines. In summary, the discovery of the MHC class II allosteric site allows one to increase the efficiency of MHC class II-related, antigenic epitope-specific therapy for malignant, infectious, and autoimmune diseases. The focus of this review is on the mechanism and potential clinical use of such novel allosteric site-directed, Ii-key drugs.
    Type of Medium: Electronic Resource
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