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  • 11
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Large-scaled hydrogen negative ion source development is reviewed for a negative ion based neutral beam injector (NBI) in the large helical device (LHD) fusion machine. The target performance of the ion source is characterized by a high current of 30–40 A with a relatively low energy of 120–180 keV. A series of negative ion source development is conducted with a one-dimensionally reduced size of ion sources which still have a large beam area of 25 cm×26 cm or 50 cm with multi apertures. We employed a cesium-seeded volume production source with an external magnetic filter for the source development. Improvement of the arc plasma confinement is effective to produce a high-current negative ion of 16 A with a current density of 31 mA/cm2 at a low operational gas pressure below 0.4 Pa. Suppression of the accelerated electrons is achieved both by strengthening the magnetic field at the extraction grid and by shaping the inside of the extraction grid aperture to shield the secondary electrons against the acceleration electric field. Multi beamlets delivered from a large area are finely focused with the aperture displacement technique applied to the grounded grid. Based on these results, the LHD-NBI negative ion source was designed and fabricated with a beam area of 25 cm×125 cm. The LHD-NBI source produced 25 A of negative ions with an energy of 104 keV at a low gas pressure of 0.3 Pa. A long-pulse negative ion beam of 81 keV–1.3 MW was produced for 10 s. Four sources were installed to the LHD-NBI system, and around 4 MW of neutral beams were injected into the LHD plasmas with an energy of 100–110 keV in the first period for the NBI experiments. The LHD-NBI ion source is still being developed to improve its performance, and the key issues for the improvement are discussed. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 12
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 61 (1987), S. 440-442 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The junction down mounting attached to a Si-submount with Au-Si solder has been shown to be very reliable for lasers by aging tests of 5 mW at 80° C. The thermal resistance of this junction down mounting is 30 K/W smaller than that of a junction up mounting. Output powers as high as cw 80 mW/stripe, corresponding to 400 mW, was realized without saturation with a five-stripe phase-locked laser array with an inner-stripe configuration assembled on this mounting.
    Type of Medium: Electronic Resource
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  • 13
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: Behavior of impurity ions has been investigated using visible spectroscopy in the GAMMA10 tandem mirror. A 40 channel visible spectrometer system has been developed for measurements of the ion temperature and ion flow velocity. The spectrometer consists of a 100 cm monochromator, a 40 channel optical fiber array and an image intensifier tube coupled with a charge coupled device TV camera. The spectra from low ionization states of oxygen and carbon are measured in ion cyclotron range of frequency heated plasmas. High ion temperatures (3–10 keV) of O4+ are observed in the anchor region, where the minimum B mirror field is produced by baseball coils. The O4+ ion is heated by the fourth harmonic frequency of O4+, which is most likely due to the cyclotron higher harmonic damping. © 1999 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 14
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 93 (1989), S. 8384-8384 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 15
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 9 (1982), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The effects of verapamil on dopamine-, secretin- and pancreozymin-induced pancreatic secretion were investigated in the isolated, blood-perfused canine pancreas in vivo.2. The volume of pancreatic secretion either in the resting state or induced by pancreozymin given intra-arterially (i.a.) was decreased by an infusion of 5 μg/min of verapamil; that induced by dopamine or secretin i.a. was also decreased but the changes were not statistically significant.3. Protein concentration in pancreatic juice either in the resting state or in that of stimulated secretion by pancreozymin was decreased significantly, but protein concentration induced by dopamine or secretin was not affected, by verapamil treatment.4. Verapamil had no effect on bicarbonate concentration in pancreatic juice secreted either in the resting state or when stimulated by these secretagogues.5 These results suggest that verapamil, at least in part, may affect the secretory mechanisms of acinar cells but not that of the ductular cells.
    Type of Medium: Electronic Resource
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  • 16
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 17
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: For compensation of the magnetically deflected beamlets, a new type of grid system has been applied to a large negative ion source of a negative-ion-based neutral beam injector in the Large Helical Device (LHD) fusion experimental machine. Corresponding to deviation of the negative ion beamlet trajectory due to the electron suppression magnetic field at the extraction grid, the exit aperture of the extraction grid is displaced to cancel the beamlet deflection by electrostatic lens effect. As a result, the beamlet deflection was suppressed less than 2 mrad in a wide range of energy of 110–180 keV, and the port-through efficiency of the injected beam was improved to 90%–95% from 70%–75% in the case of the previous compensation by the grounded grid aperture displacement. The injected beam power was increased to 3.5 MW with an energy of 165 keV using one injector. To improve beam uniformity of the large area beam, individual arc currents through filaments are controlled for uniform plasma production, with independent 12 arc power supplies connected to 12 filament power supplies. The initial results show good controllability of the individual arc current distribution at a high arc power. The improvement of the ion source performance would lead to an increase in the injection power in the following LHD experimental campaign. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 18
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: A beam steering technique using aperture displacement was examined to correct the negative ion beam deflection due to the magnetic field for electron suppression in a large-area multibeamlet H− source. The total deflection angle was estimated, including the effect of the deflection by the electron suppression magnetic field and the beam steering by the aperture displacement, both by linear optics theory and by three-dimensional beam trajectory simulation. Two methods were compared; one used the displacement both of the grounded grid (GG) apertures and of the exit part of the extraction grid (EG exit) apertures, and the other used the displacement only of the EG exit. The beam steering experiments were performed using a large-area multibeamlet H− source with both displacement methods, and the results were compared with the theoretical estimations. As a result, both methods were effective to correct the beam deflection. In particular, the displacement of only the EG exit with a simplified displacement structure achieved a large steering angle by a small displacement. The steering angle in the experiment was a few mrad smaller than the estimations. Based on these results, the aperture displacement of the EG exit was applied to the 1/5 segment of a H− source in the Large-Helical-Device neutral beam injector, where the GG apertures are displaced only focusing of the large-area multibeamlet. In this case, 1.0 mm of the displacement is concluded to be proper to sufficiently compensate the beam deflection at 180 keV, from extrapolation of the beam energy characteristics at 100–140 kev. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 19
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background A number of studies support the belief that human basophils play an important role in allergic inflammation. The exact mechanism of basophil activation at the site of allergic inflammation, however, has not been well understood, mainly due to their low number in blood and difficulty in obtaining a sufficient number of highly purified basophils for investigation.Objective The purpose of this study is to expand human basophils in vitro with high yield and purity by culturing peripheral blood stem cells (PBSCs).Methods We collected PBSC-rich mononuclear cells containing CD34+ cells (0.15–4.9%) by leukapheresis from patients with malignant lymphoma and lung cancer during haematopoietic recovery after chemotherapy plus granulocyte colony-stimulating factor-induced mobilization. PBSC-rich mononuclear cells were cultured in the presence of IL-3.Results When PBSC-rich mononuclear cells containing more than 1% of CD34+ cells were cultured, 20.0–83.3% of the cells, mostly with a yield of 〉10%, were metachromatic cells after 3 weeks of culture. These cells resembled mature peripheral blood basophils morphologically when examined by light and electron microscopy. Flow cytometric analysis showed that they expressed both FcɛRI and FcγRII. FcɛRI cross-linking resulted in intracellular calcium mobilization, histamine release and synthesis of cysteinyl leukotrienes. The intracellular histamine content and the release of these chemical mediators triggered by anti-IgE antibodies were comparable to those of peripheral blood basophils.Conclusion These findings suggest that PBSC-derived basophils expanded in vitro are morphologically and functionally mature and will be a useful tool for the analysis of basophil functions.
    Type of Medium: Electronic Resource
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  • 20
    Electronic Resource
    Electronic Resource
    Oxford BSL : Blackwell Science Ltd
    Anaesthesia 52 (1997), S. 0 
    ISSN: 1365-2044
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We evaluated the effects of clonidine given orally on sevoflurane requirements for anaesthesia and hypnosis. Patients received either clonidine (5 μg.kg−1) by mouth (n =21) 90 min before surgery or no premedication (n =21) by random allocation. MAC was calculated using repeated tetanic nerve stimulation with end-tidal sevoflurane concentration increased or decreased by 0.3 vol.% depending on the previous response. MAC awake was calculated according to the response to verbal command. The mean (SD) MAC in the clonidine-treated patients was 1.53 (0.20)% compared with 1.83 (0.15)% in the control group (p 〈0.001). Similarly, MAC awake was reduced in the clonidine group (0.50 (0.08)% compared with 0.60 (0.07)% in the control group) (p 〈0.001). We conclude that clonidine 5 μg.kg−1 orally administered pre-operatively reduces sevoflurane requirements for anaesthesia and hypnosis.
    Type of Medium: Electronic Resource
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