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  • 11
    Electronic Resource
    Electronic Resource
    Vibrating hand-held machines in the construction industry
    Amsterdam : Elsevier
    Safety Science 15 (1992), S. 367-373 
    Details
    ISSN: 0925-7535
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Technology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0925-7535(92)90025-U
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  • 12
    Electronic Resource
    Electronic Resource
    Cystatin C and transthyretin expression in normal and neoplastic tissues of the human brain and pituitary (1997)
    Springer
    Acta neuropathologica 93 (1997), S. 494-500 
    Details
    ISSN: 1432-0533
    Keywords: Key words Cystatins ; Transthyretin ; Brain tumors ; Pituitary adenomas ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The localization of cystatin C (CC) and transthyretin (TTR) synthesis was studied using Northern blot and immunohistochemical methods. Normal brain tissues from all sites studied contained CC mRNA. Immunoreactive CC was present in the choroid plexus epithelial cells, cerebral and cerebellar neurons, astrocytes, ependymal cells, macrophage-like cells of the arachnoid membrane and in neuroendocrine cells of the anterior pituitary lobe. TTR mRNA and TTR were restricted to the choroid plexus. In primary brain tumors, the transcript for CC was found in all 39 tumors examined, while the protein could only be demonstrated in 3/5 choroid plexus papillomas, 8/8 astrocytomas, 7/23 anaplastic astrocytomas and glioblastomas, 1/6 oligodendrogliomas, 1/1 oligoastrocytoma, 1/4 anaplastic oligodendrogliomas, 3/7 ependymomas, 0/1 anaplastic ependymoma, 0/5 primitive neuroectodermal tumors, 0/1 neuroblastoma, 3/11 meningiomas and 16/16 pituitary adenomas. CC cannot be used as a marker for any specific brain tumor type but the fact that the protein could be demonstrated more frequently in astrocytomas than in their more malignant counterparts suggests that the cellular production and secretion of CC changes with the malignant progression of these tumors. TTR mRNA and TTR were present only in the choroid plexus papillomas, indicating that TTR synthesis is mainly restricted to such brain neoplasms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004010050644
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  • 13
    Electronic Resource
    Electronic Resource
    Influence of cell size on the effects of insulin and noradrenaline on human adipose tissue (1976)
    Springer
    Diabetologia 12 (1976), S. 69-72 
    Details
    ISSN: 1432-0428
    Keywords: Human adipose tissue ; lipolysis ; noradrenaline ; insulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the present study dose-response relationships of the effects of noradrenaline and insulin on fat cells of different sizes were performed. Adipose cells larger than 100 μm were more responsive (expressed as absolute effects) to the lipolytic action of noradrenaline as well as to the antilipolytic effect of insulin. This suggests that in the larger cells thecapacity, i. e. the sum of factors contributing to the ability to stimulate or inhibit the metabolic rates, was greater than in the smaller ones. In contrast thesensitivity to these agents, i.e. the readiness to respond, was not different between small and large cells. It is shown that the concentrations of insulin needed to obtain an antilipolytic effect is far below that needed to stimulate glucose incorporation. This discrepancy in insulin concentrations required may be due to binding of insulin to receptors with different affinity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01221967
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  • 14
    Electronic Resource
    Electronic Resource
    Acute hydrops of the gallbladder in childhood (1992)
    Springer
    European journal of pediatrics 151 (1992), S. 318-320 
    Details
    ISSN: 1432-1076
    Keywords: Gallbladder hydrops ; Ultrasonography ; Abdominal mass
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute hydrops of the gallbladder (AHGB) is a rare paediatric disease being diagnosed with increased frequency due to its association with other illnesses and the availability of ultrasonography. The symptoms and signs of AHGB include abdominal pain, vomiting, abdominal mass and/or tenderness. As these clinical features mimic the more common surgical conditions such as acute appendicitis, intussusception and volvulus, some cases are still diagnosed only at laparotomy. diagnosis is established by ultrasonography of the abdomen demonstrating normal biliary ducts and a distended gallbladder without calculi or congenital malformation. The aetiology of acute hydrops of the gallbladder is unknown but may be multifactorial. Treatment varies from non-operative management to surgical intervention.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02113247
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  • 15
    Electronic Resource
    Electronic Resource
    In situ localization of transthyretin-mRNA in the adult human liver, choroid plexus and pancreatic islets and in endocrine tumours of the pancreas and gut (1989)
    Springer
    Histochemistry and cell biology 91 (1989), S. 299-304 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In situ hybridization with 35S-labeled single stranded RNA probes was used on sections from formaldehyde-fixed and paraffin-embedded tissue specimens to provide semiquantitative data on the occurrence of transthyretin(TTR)-mRNA in human liver, choroid plexus and pancreatic islets as well as in 15 endocrine tumours of the pancreas and gut. A monoclonal antibody to TTR was used for immunocytochemical identification of the protein in consecutive sections. The amount of TTR-mRNA in hepatocytes was found to be much less than that in epithelial cells of the choroid plexus. Glucagon cells of the pancreatic islets were also specifically labeled and the level of TTR-mRNA in these cells was intermediate between that of hepatocytes and choroid plexus epithelial cells. Four glucagonomas, one malignant insulinoma and two midgut carcinoids were shown to contain TTR-mRNA. The ‘in situ’ labeled cells were also found to be TTR immunoreactive. These findings present the first conclusive evidence for TTR synthesis in pancreatic islets and in endocrine tumours. They also establish that the high serum concentration of TTR found in some patients with endocrine tumours (notably glucagonomas) is most likely due to tumour production of TTR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00493004
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  • 16
    Electronic Resource
    Electronic Resource
    Symptomatic urinary tract infection in boys in the first year of life with special reference to scar formation (1973)
    Springer
    Infection 1 (1973), S. 192-199 
    Details
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Es wird von 70 männlichen Säuglingen mit klinisch manifesten, möglichen Erstinfektionen der Harnwege berichtet, die zwischen dem zweiten und zwölften Lebensmonat auftraten. Im Laufe der Untersuchungszeit lag die Häufigkeit scheinbar bei 1,2‰ der Geburten. Acht (11%) Säuglinge wiesen obstruktive Harnwegsanomalien auf und wurden bei den folgenden Untersuchungen nicht berücksichtigt. 51 der 62 Fälle ohne Obstruktionen wurden von zwei bis 12 Jahren verfolgt. Hohes Fieber und Reizbarkeit waren stark hervortretende Symptome. Eine Gedeihstörung wurde nur bei einem Kind beobachtet. Fieberanfälle traten häufig in dem Monat vor der ersten Urinuntersuchung auf und deuteten auf eine mögliche unerkannte Harnwegsinfektion (HWI) hin. Für 87% der Infektionen war E. coli ätiologisch verantwortlich. Eine Pyurie bestand bei 97% der Kinder. Auf die Schwierigkeiten der bakteriologischen Diagnostik von HWI bei Jungen im ersten Lebensjahr wird hingewiesen. Bei den meisten Fällen wurde die Konzentrationskapazität vorübergehend herabgesetzt. Die Harnstoff-N-Werte im Blut waren bei allen untersuchten Fällen normal. Eine Elimination der Bakterien wurde mit einer 10tägigen Behandlung erreicht. Mit einer Ausnahme traten die Rezidive bei 20% der Fälle innerhalb eines Jahres nach der Erstinfektion auf. Es wird daraus geschlossen, daß Jungen mit einer möglichen Erstinfektion innerhalb des ersten Lebensjahres nur ein halbes Jahr lang beobachtet werden müssen. Bei sechs Fällen wurden Narbenbildungen entweder sicher nachgewiesen oder vermutet; vier Fälle waren ohne ausgeprägten Reflux. Daraus kann geschlossen werden, daß das Risiko von Nierenparenchymzerstörung in dieser Altersgruppe hoch zu sein scheint, sogar wenn die Diagnose frühzeitig gestellt wird und es gelingt, die Bakterien zu eliminieren. Eine Blasenausgangsstenose wurde bei sieben Patienten gefunden, doch es bestand keine Beziehung zum Reflux. Es wird vor chirurgischen Maßnahmen ohne dringenden Anlaß gewarnt, da dies zur andauernden und schwer zu behandelnden Infektion führen kann.
    Notes: Summary This study describes consecutive observations made on 70 boys with a symptomatic urinary tract infection occurring apparently for the first time with onset between the second and twelfth month of life. During the observation period the apparent frequency was 1.2 per 1,000 births. Eight cases (11%) had obstructive malformations and were excluded from the following analysis. Fifty-one of the 62 cases without obstruction were followed up for two to twelve years. High fever and irritability were conspicuous symptoms; “failure to thrive“ was seen in only one infant. Attacks of fever during the month preceeding the first urine examination were common and were possibly indicative of unrecognised urinary infection. E. coli caused 87% of the infections; pyuria was demonstrated in 97%. The difficulties in the bacteriological diagnosis of UTI in young boys are emphasized. A temporary decrease in the concentrating capacity was seen in most cases. The blood urea nitrogen concentration was normal in all cases investigated. Elimination of bacteriuria was achieved easily with ten days' treatment. Recurrences occurred in 20% and within a year of the first infection except in one case. It is concluded that follow-up for one year may be sufficient in males with an apparent first infection during the first year of life. Scarring was confirmed or strongly suspected in six cases (10%), four without gross reflux. The risk of renal damage thus seems to be high in males of this age group even when diagnosis is made early on and bacteria are rapidly eliminated. Calcyceal cysts not seen at first examination appeared later in four patients. Narrowing of the outflow region of the bladder was seen in seven patients. There was no relation to reflux. We would warn against surgical intervention without strict indication as it may be followed by prolonged infection which is difficult to treat.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01639648
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  • 17
    Electronic Resource
    Electronic Resource
    A review of children operated upon because of stenosis of the pelvo-ureteral junction (1975)
    Springer
    International urology and nephrology 7 (1975), S. 103-107 
    Details
    ISSN: 1573-2584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The authors report the late results of reconstructive surgery on sterosis of the pelvo-ureteral junctions in children. 68 patients had been operated during 1965–1970. The results on clinical grounds were good: the infections and pain disappeared and the renal function was normal; however, the operation had no noticeable effect on the hydronephrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02085428
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  • 18
    Electronic Resource
    Electronic Resource
    Piroxicam and indometacin suppositories for painful coxarthrosis (1992)
    Springer
    Clinical rheumatology 11 (1992), S. 37-40 
    Details
    ISSN: 1434-9949
    Keywords: Osteoarthritis ; Piroxicam ; Indometacin ; Suppositories ; Efficacy ; Side Effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Six orthopaedic clinics in Sweden made a comparison of the effects and side effects of Piroxicam (20mg) and Indometacin (100mg) suppositories in 261 patients with painful coxarthrosis on the waiting list for total hip replacement (THR). The study was designed as a single blind study over 4 weeks. Amount of pain and range of motion was registered before the trial and compared with findings after 4 weeks, including reported side effects. Both drugs gave satisfactory pain relief without any appreciable variation on weightbearing or at rest. On the other hand, the trial showed a significant difference (p=0.0033, Student's-test) between the two drugs as regards the frequency of side effects from the lower gastrointestinal tract, where piroxicam had a lower rate compared with indometacin. No serious complications occurred; 16 patients dropped out, 8 in each group.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02207081
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