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  • 11
    Electronic Resource
    Electronic Resource
    Inhibitory effects of propofol on catecholamine secretion and uptake in cultured bovine adrenal medullary cells (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 353 (1996), S. 572-578 
    Details
    ISSN: 1432-1912
    Keywords: Key words Adrenal medulla ; Catecholamine secretion ; Inhibition ; 22Na+ influx ; Noradrenaline uptake ; Propofol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the central and peripheral noradrenergic neurons, the balance between noradrenaline release and reuptake determines the level of noradrenaline at the synaptic cleft or the nerve ending. In the present study, we examined the effects of propofol, an intravenous general anaesthetic, on catecholamine secretion and noradrenaline uptake in cultured bovine adrenal medullary cells and on the serum noradrenaline and blood pressure in rats. In cultured adrenal medullary cells, propofol (10–50 μmol/l) concentration-dependently inhibited catecholamine secretion stimulated by carbachol. Propofol suppressed carbachol-evoked 22Na+ influx as well as 45Ca2+ influx at concentrations similar to those which suppressed the catecholamine secretion. Propofol (10–50 μmol/l) also inhibited veratridine-evoked 22Na+ influx, 45Ca2+ influx and catecholamine secretion, whereas it had little effect on the 45Ca2+ influx and catecholamine secretion induced by 56 mmol/l K+. Cultured adrenal medullary cells show [3H] noradrenaline uptake which is sensitive to imipramine. Propofol (10–50 μmol/l) significantly inhibited the imipramine-sensitive uptake of [3H] noradrenaline. In rats, intravenous administration of propofol (2.5 mg/kg) lowered serum noradrenaline and arterial blood pressure. From these findings, in spite of inhibiting noradrenaline uptake, propofol at anaesthetic concentrations (10–30 μmol/l) seems to reduce catecholamine secretion by interfering with Na+ influx through voltage-dependent Na+ channels as well as nicotinic acetylcholine receptor-associated ion channels in the adrenal medulla and, probably, in the sympathetic nervous system. This may explain the propofol-induced hypotension during anaesthesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169178
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    Paper (German National Licenses)
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  • 12
    Electronic Resource
    Electronic Resource
    Inhibitory effects of propofol on catecholamine secretion and uptake in cultured bovine adrenal medullary cells (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 353 (1996), S. 572-578 
    Details
    ISSN: 1432-1912
    Keywords: Adrenal medulla ; Catecholamine secretion ; Inhibition ; 22Na+ influx ; Noradrenaline uptake ; Propofol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the central and peripheral noradrenergic neurons, the balance between noradrenaline release and reuptake determines the level of noradrenaline at the synaptic cleft or the nerve ending. In the present study, we examined the effects of propofol, an intravenous general anaesthetic, on catecholamine secretion and noradrenaline uptake in cultured bovine adrenal medullary cells and on the serum noradrenaline and blood pressure in rats. In cultured adrenal medullary cells, propofol (10–50 μmol/l) concentration-dependently inhibited catecholamine secretion stimulated by carbachol. Propofol suppressed carbachol-evoked 22Na+ influx as well as 45Ca2+ influx at concentrations similar to those which suppressed the catecholamine secretion. Propofol (10–50 μmol/l) also inhibited veratridine-evoked 22Na+ influx, 45Ca2+ influx and catecholamine secretion, whereas it had little effect on the 45Ca2+ influx and catecholamine secretion induced by 56 mmol/l K+. Cultured adrenal medullary cells show [3H] noradrenaline uptake which is sensitive to imipramine. Propofol (10–50 μmol/l) significantly inhibited the imipramine-sensitive uptake of [3H] noradrenaline. In rats, intravenous administration of propofol (2.5 mg/kg) lowered serum noradrenaline and arterial blood pressure. From these findings, in spite of inhibiting noradrenaline uptake, propofol at anaesthetic concentrations (10–30 μmol/l) seems to reduce catecholamine secretion by interfering with Na+ influx through voltage-dependent Na+ channels as well as nicotinic acetylcholine receptor-associated ion channels in the adrenal medulla and, probably, in the sympathetic nervous system. This may explain the propofol-induced hypotension during anaesthesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00169178
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 13
    Electronic Resource
    Electronic Resource
    Intra-operative blood pressure control by prostaglandin E1 in patients with hypertension and ischemic heart disease (1993)
    Springer
    Journal of anesthesia 7 (1993), S. 173-183 
    Details
    ISSN: 1438-8359
    Keywords: Prostaglandin E1 ; Deliberate hypotension ; Intra-operative hypertension ; Ischemic heart disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The purpose of this multi-center study was to evaluate the efficacy and safety of prostaglandin E1 (PGE1) administration in achieving deliberate hypotension and in treating intraoperative hypertension for patients with a history of hypertension and ischemic heart disease. PGE1 (0.08 µg·kg−1·min−1) decreased systolic blood pressure from 125 ± 29 to 106 ± 22 mmHg (mean ± SD) in the deliberate hypotension group (n = 158) and from 155 ± 34 to 125 ± 32 mmHg in the antihypertension group (n = 55). The heart rate significantly increased from 80 ± 15 to 85 ± 18 beats·min−1 in the deliberate hypotension group, but was not significantly altered in the antihypertension group. The time required to obtain the desired level of blood pressure was approximately 20 min in the deliberate hypotension group. When the infusion was stopped, blood pressure returned approximately to the preinfusion level within about 20 min. No rebound hypertension was observed. PGE1 significantly increased the urine flow in patients who had a low urine flow before PGE1 infusion. Thirteen out of 213 patients (5.6%) had side effects such as excessive hypotension (1%), phlebitis (3%), and unexpected tachycardia (1%), which were alleviated gradually after discontinuation of PGE1 infusion. No dysarrhythmia and further ST segment changes in the electrocardiograms were observed. These findings suggest that PGE1 can be safely used to control arterial blood pressure during surgery in patients having preoperative hypertension and ischemic heart disease. (Hoka S, Yoshitake J, Dan K, et al.: Intra-operative blood pressure control by prostaglandin E1 in patients with hypertension and ischemic heart disease. A multi-center study. J Anesth 7: 173–183, 1993)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054030070173
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    Paper (German National Licenses)
    Fulltext
  • 14
    Electronic Resource
    Electronic Resource
    Blood pressure, heart rate and catecholamine response during fiberoptic nasotracheal intubation under general anesthesia (1992)
    Springer
    Journal of anesthesia 6 (1992), S. 474-479 
    Details
    ISSN: 1438-8359
    Keywords: Broncho-fiberscope ; Tracheal intubation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Arterial blood pressure (ABP) and heart rate were recorded at one-minute intervals during several stages of intubation in the fiberscope group and the laryngoscope group, to determine if fiberoptic nasotracheal intubation would result in fewer hemodynamic and catecholamine responses than when intubation was performed with a Macintosh laryngoscope. Blood samples were also taken to measure plasma catecholamine concentration immediately after intubation with the fiberscope. The mean ABP in the laryngoscope group was slightly greater than that of the fiberscope group for 4 min after intubation. Heart rates at 2 min and 4 min after intubation in the laryngoscope group were significantly greater than those for the fiberscope group. Even immediately after intubation, the mean plasma levels of epinephrine and norepinephrine were unchanged in the fiberscope group. Arterial oxygen saturation (SpO 2) was maintaind within normal range during both of intubation procedures, although the time required for intubation was longer than in the laryngoscope group. Other cardiovascular complications were more common in the laryngoscope group than in the fiberscope group. These results suggest that fiberoptic intubation results in less severe stress than does laryngoscopic intubation. Fiberoptic intubation should therefore be used not only in patients with difficult airway, hypertension, ischemic heart disease, or cerebrovascular atherosclerosis, but also it is recommended for all patients for whom nasotracheal intubation is indicated. (Tsubaki T, Aono K, Nakajima T, et al.: Blood pressure, heart rate and catecholamine response during fiberoptic nasotracheal intubation under general anesthesia. J Anesth 6: 474–479, 1992)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s0054020060474
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    Paper (German National Licenses)
    Fulltext
  • 15
    Electronic Resource
    Electronic Resource
    General anesthesia for progressive external ophthalmoplegia syndrome (1995)
    Springer
    Journal of anesthesia 9 (1995), S. 283-284 
    Details
    ISSN: 1438-8359
    Keywords: General anesthesia ; Progressive external ophthalmoplegia syndrome ; Vecuronium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02479879
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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