Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 11
    Electronic Resource
    Electronic Resource
    Differential scanning calorimetry (DSC) at high pressure
    Amsterdam : Elsevier
    Thermochimica Acta 49 (1981), S. 23-24 
    Details
    ISSN: 0040-6031
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0040-6031(81)85139-8
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 12
    Electronic Resource
    Electronic Resource
    Angiotensin converting-enzyme inhibitor treatment reduces glomerular p16INK4 and p27Kip1 expression in diabetic BBdp rats (1999)
    Springer
    Diabetologia 42 (1999), S. 1425-1432 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Diabetic nephropathy, cyclin-dependent kinase inhibitors, glomerular hypertrophy, cell cycle arrest, angiotensin II, progression of renal failure.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Renal hypertrophy occurs early in diabetes mellitus and precedes the development of glomerulosclerosis and tubulointerstitial fibrosis. We have previously shown that cultured mesangial cells exposed to high glucose are arrested in the G1-phase of the cell cycle and undergo cellular hypertrophy. High glucose-mediated induction of p27Kip1, an inhibitor of cyclin-dependent kinases, is essential in this process. Further investigations have also shown that p27Kip1 and p21Cip1, other cyclin-dependent kinase inhibitors, are up regulated in the kidneys of mice with Type I (insulin-dependent) as well as Type II (non-insulin-dependent) diabetes mellitus. Our study was undertaken to test a potential effect of short-term treatment with the angiotensin-converting enzyme inhibitor enalapril on the glomerular expression of the cyclin-dependent kinase inhibitors p16INK4, p21Cip1, and p27Kip1 in BBdp rats, an autoimmune model of Type I diabetes.¶Methods. We evaluated p16INK4, p21Cip1, and p27Kip1 protein expression in isolated glomeruli by western blots. We also assessed p27Kip1 positive glomerular cells by immunohistochemistry.¶Results. Glomerular expression of all three cyclin-dependent kinase inhibitors were stimulated in BBdp rats compared with non-diabetic BBdr animals. Enalapril treatment for 3 weeks, started after the onset of diabetes, reduced the glomerular expression of p16INK4 and p27Kip1 but not of p21Cip1. Enalapril also prevented the increase in kidney weights observed in BBdp rats but had no effect on systolic blood pressure or glucose concentrations.¶Conclusion/interpretation. Our data show that enalapril attenuates the glomerular expression of cyclin-dependent kinase inhibitors in diabetes and suggest a molecular mechanism of how angiotensin-converting enzyme inhibitors prevent renal hypertrophy in diabetes. [Diabetologia (1999) 42: 1425–1432]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051314
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 13
    facet.materialart.
    Unknown
    F. Kaulbach, Immanuel Kant's, Grundlegung zur Metaphysik der Sitten' (Book Review) (1989)
    Berlin : Periodicals Archive Online (PAO)
    Kant-Studien. 80:4 (1989) 472 
    Details
    ISSN: 0022-8877
    Topics: Philosophy
    Notes: "Buchbesprechungen"
    URL: http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:0171-1989-080-04-000005
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 14
    Electronic Resource
    Electronic Resource
    Einfluß der Heizflächenbeschichtung auf den Wärmeübergangskoeffizienten beim Behältersieden von Wasser, Isopropanol, Azeton und deren Mischungen (1993)
    Springer
    Heat and mass transfer 28 (1993), S. 465-470 
    Details
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Zusammenfassung In der vorliegenden Arbeit wird der Wärmeübergang von drei Stahlheizstäben mit unterschiedlicher Oberfläche verglichen. Ein Heizstab wurde mit einer perforierten Messingfolie umhüllt, der zweite mit Teflon beschichtet, während der dritte unbeschichtet verwendet wurde. Als Testflüssigkeiten wurden Wasser, Azeton, Isopropanol und deren Mischungen verwendet.
    Notes: Abstract This article compares pool boiling heat transfer from three stainless steel heating rods with different surfaces. One heating rod was covered with a perforated brass foil, one was coated with teflon and the third was used without any coating. Water, acetone, isopropanol and their mixtures were used as test liquids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01539677
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 15
    Electronic Resource
    Electronic Resource
    Eine 73jährige Patientin mit hypertensiver Krise War der Einsatz des Kalziumantagonisten Nifedipin gerechtfertigt? (1999)
    Springer
    Der Internist 40 (1999), S. 205-209 
    Details
    ISSN: 1432-1289
    Keywords: Schlüsselwörter Nifedipin ; Kalziumantagonisten ; Koronare Herzkrankheit ; Hypertensive Krise ; Hypertensive Dringlichkeit ; Evidence Based Medicine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Eine 73jährige Patientin erwachte in der Nacht mit linksthorakalen Schmerzen und Herzklopfen. Der herbeigerufene Notarzt diagnostizierte eine hypertensive Krise. Der Blutdruck war 260/120 mm Hg, und der Notarzt verabreichte 50 mg Urapidil i.v.. Es folgte der Transport in die Klinik. In der Notaufnahme war der Blutdruck mit 190/120 mm Hg weiterhin erhöht. Die Patientin war beschwerdefrei. Das EKG zeigte keine Ischämie-typischen oder Infarkt-verdächtigen Veränderungen. Nach Gabe von 10 mg Nifedipin als Kapsel kam es zum schnellen Abfall des Blutdrucks auf 120/80 mm Hg. Es entwickelte sich eine Tachykardie, und heftige linksthorakale Schmerzen traten auf. Das EKG zeigte eine Sinustachykardie mit Ischämie-typischen ST-Streckensenkungen von 0.3 mV in den Brustwandableitungen. Die Symptomatik besserte sich nach i.v. Gabe von Nitroglycerin und Frequenzkontrolle. Das 12 h später geschriebene EKG zeigte keine Ischämie-typischen Veränderungen. Nach Intensivierung der antihypertensiven Therapie wurde die Patientin beschwerdefrei entlassen. Bei der Patientin waren durch die Gabe von Nifedipin Angina pectoris Beschwerden und ischämietypische EKG-Veränderungen ausgelöst worden. Wir diskutieren, warum wir trotz dieser Beobachtung den Gebrauch von Nifedipinkapseln bei der hypertensiven Krise für gerechtfertigt halten.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001080050325
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 16
    Electronic Resource
    Electronic Resource
    Unterkühltes Sieden strömender Flüssigkeitsgemische (1991)
    Springer
    Heat and mass transfer 26 (1991), S. 265-271 
    Details
    ISSN: 1432-1181
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Description / Table of Contents: Zusammenfassung Es werden Meßergebnisse zum Wärmeübergang beim unterkühlten Sieden von Isopropanol/Wasser-Gemischen in einem senkrechten Ringspalt bei Aufwärtsströmung vorgestellt. Der Einfluß der Versuchsparameter Wärmestromdichte, Flüssigkeitsgeschwindigkeit, Flüssigkeitsunterkühlung und Flüssigkeitszusammensetzung auf den Wärmeübergang im Blasensiedebereich wird dargestellt. Die gemessenen Wärmeübergangskoeffizienten werden mit den Vorhersagen zweier Korrelationen für gesättigtes Sieden aus der Literatur verglichen. Die Übereinstimmung zwischen Meßwerten und Korrelationen ist zufriedenstellend.
    Notes: Abstract Experimental results for subcooled flow-boiling heat transfer to isopropanol/water-mixtures in a vertical annulus during upward flow are reported. The influence of heat flux, flow velocity subcooling and mixture composition on heat transfer in the nucleate boiling region is discussed. The measured subcooled boiling heat transfer coefficients are compared with the predictions of two correlations for saturated boiling suggested in the literature. It was found that these correlations agree well with the present measurements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01589998
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 17
    Electronic Resource
    Electronic Resource
    Comparison of different methods for dead space measurements in ventilated newborns using CO2-volume plot (1999)
    Springer
    Intensive care medicine 25 (1999), S. 705-713 
    Details
    ISSN: 1432-1238
    Keywords: Key words Respiratory dead space ; Carbon dioxide ; Lung function testing ; Mechanical ventilation ; Newborn ; Single breath test
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: The aim of the study was to test the applicability of Ventrak 1550/Capnogard 1265 (V-C) for respiratory dead space (Vd) measurement and to determine anatomic (VDana), physiologic (VDphys), and alveolar dead spaces (VDalv) in ventilated neonates. Design: Prospective study. Setting: Neonatal intensive care unit. Patients: 33 investigations in 22 ventilated neonates; median gestational age 34.5 weeks (range 27–41), median birthweight 2658 g (range 790–3940). Method: The single-breath CO2 test (SBT-CO2) and transcutaneous partial pressure of carbon dioxide (PCO2) were recorded simultaneously and Vd was determined (1) automatically (V-C software), (2) by interactive analysis of the PCO2 volume plot, and (3) manually by Bohr/Enghoff equations using data obtained by V-C. Results: Vd measurements were possible in all cases by method 3 but not possible by methods 1 and 2 in 22 of 33 investigations (67 %), especially in preterm neonates, because of disturbed signals. VDana/kg (1.6 ± 0.6 ml/kg, mean ± SD), VDana/tidal volume (Vt) (0.36 ± 0.09) were lower compared to published data in spontaneously breathing infants, whereas VDphys/kg (2.3 ± 0.9 ml/kg) and VDphys/Vt (0.50 ± 0.12) are comparable to data obtained from the literature. Five minutes after insertion of the sensor (dead space 2.6 ml) into the ventilatory circuit, the transcutaneous PCO2 rose above baseline for 3.2 % (patients 〉 2500 g) and 5.7 % (patients 〈 2500 g). The time necessary for one analysis was 50–60 min. Conclusion: In ventilated newborns, dead space measurements were possible only in one-third by SBT-CO2, but in all cases by Bohr/Enghoff equations. Improved software could further reduce the time needed for one analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001340050933
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 18
    Electronic Resource
    Electronic Resource
    Zur Klinik und Neuropathologie metaneoplastischer Encephalitiden (1971)
    Springer
    Journal of neurology 200 (1971), S. 233-247 
    Details
    ISSN: 1432-1459
    Keywords: Metaneoplastic Encephalitis ; Encephalitis of the Brain-Stem ; Limbic Encephalitis ; Subacute Cerebellar Degeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Klinik und neuropathologische Befunde bei metaneoplastischer Encephalitis werden an Hand zweier eigener Beobachtungen beschrieben. Einmal handelt es sich um einen 54jährigen Mann, der an einem Bronchialcarcinom erkrankt war, zum anderen um eine 59jährige Frau mit einem malignen Ovarialtumor. Bei beiden Patienten standen während der 11- bzw. 18monatigen Krankheitsdauer cerebelläre Symptome im Vordergrund. Histologisch fand sich das Bild eines ausgedehnten, perivasalen lymphocytär-entzündlichen Prozesses mit diffusen und knötchenartigen Gliareaktionen unter Bevorzugung des temporo-insulären Cortex, der Stammganglien des Hirnstammes und des Kleinhirns mit nahezu vollständigem Untergang der Purkinjezellen. Die einschlägige Literatur wird vergleichend erörtert.
    Notes: Summary The clinical and pathological features of encephalitis associated with a carcinoma in the absence of cerebral metastases are described as occurring in a 54-year-old man with a bronchial carcinoma and a 59-year-old woman with an ovarian cancer. The illness lasted for 11 and 18 months respectively. The salient clinical feature was a severe disturbance of cerebellar functions. The essential pathological findings were that of encephalitis, including perivascular cuffing, diffuse gliosis and glial nodule formation. The most striking changes were found in the medial temporal cortex, the basal ganglia, brain stem and cerebellum; there was a nearly complete loss of Purkinje cells. The relevant literature is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00316921
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 19
    Electronic Resource
    Electronic Resource
    Transport of Charged Dipeptides by the Intestinal H+/Peptide Symporter PepT1 Expressed in Xenopus laevis Oocytes (1997)
    Springer
    The journal of membrane biology 155 (1997), S. 247 -256 
    Details
    ISSN: 1432-1424
    Keywords: Key words: Intestinal peptide transporter — Expression — Substrate specificity — Two-electrode voltage-clamp technique
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract. The cloned intestinal peptide transporter is capable of electrogenic H+-coupled cotransport of neutral di- and tripeptides and selected peptide mimetics. Since the mechanism by which PepT1 transports substrates that carry a net negative or positive charge at neutral pH is poorly understood, we determined in Xenopus oocytes expressing PepT1 the characteristics of transport of differently charged glycylpeptides. Transport function of PepT1 was assessed by flux studies employing a radiolabeled dipeptide and by the two-electrode voltage-clamp-technique. Our studies show, that the transporter is capable of translocating all substrates by an electrogenic process that follows Michaelis Menten kinetics. Whereas the apparent K0.5 value of a zwitterionic substrate is only moderately affected by alterations in pH or membrane potential, K0.5 values of charged substrates are strongly dependent on both, pH and membrane potential. Whereas the affinity of the anionic dipeptide increased dramatically by lowering the pH, a cationic substrate shows only a weak affinity for PepT1 at all pH values (5.5–8.0). The driving force for uptake is provided mainly by the inside negative transmembrane electrical potential. In addition, affinity for proton interaction with PepT1 was found to depend on membrane potential and proton binding subsequently affects the substrate affinity. Furthermore, our studies suggest, that uptake of the zwitterionic form of a charged substrate contributes to overall transport and that consequently the stoichiometry of the flux-coupling ratios for peptide: H+/H3O+ cotransport may vary depending on pH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002329900177
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 20
    Electronic Resource
    Electronic Resource
    On-line scintillation counting on MeltilexTM basis (1996)
    Springer
    Journal of radioanalytical and nuclear chemistry 203 (1996), S. 87-96 
    Details
    ISSN: 1588-2780
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering
    Notes: Abstract A detection system is described for monitoring on-line radioactive process solutions by solid scintillation counting. The system consists of a flow cell with perspex windows coated with the plastic scintillator MeltilexTM. The cell is confined in a chamber welded to a La Calhène container. Thus the detection device is easily attached to, detached from and transported between glove boxes, and the electronic parts and the multiplers can be kept outside the box containment. Using outside coated windows, the detector responds to γ radiation, using inside coated windows, α and β particles can be detected. Selective measurements can be carried out by installing a chromatographic column in the detector loop. The detection limits of the cell for Am amount to 4·10−9 g Am/ml for outside coated windows and 10−9 g Am/ml for inside coated windows. windows and 10−9 g Am/ml for inside coated windows.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02060383
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...