ISSN:
1013-9826
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
Notes:
In this study the degradation behaviour of pure hydroxyapatite (HA), pure tricalciumphosphate (β-TCP) and four biphasic calcium phosphate ceramics was studied to gain informationabout the influence of the phase composition on this property with the aim to tailor individuallyadapted bone substitute materials. The chemical dissolution of each ceramic composition wasmeasured by its release of calcium ions into a buffered solution. With decreasing HA content in theceramics the degradation rate increased. Cell experiments were carried out with stimulatedosteoclast-like RAW 264.7 cells. Using biochemical, genetic and microscopic analysis, thedifferentiation of the cells on the ceramic samples was studied. The monocytic precursor cellsdifferentiated into osteoclast-like cells on all ceramics. The strongest cell differentiation intoosteoclast-like cells was found on ceramics with HA/β-TCP ratios of 80/20, 60/40 and 40/60. Cellson these ceramics had many nuclei and the largest cell size. As a result of resorption, lacunas werefound on all ceramics except β-TCP. All these experimental results proved the influence of thephase composition on degradation and resorption of calcium phosphate ceramics. Biphasic calciumphosphate ceramics with HA/β-TCP ratios of 80/20 and 60/40 exhibited the most promisingproperties to serve as synthetic bone substitute materials because for integration in the physiologicalbone remodeling process the implanted bone substitute materials should have optimized dissolutionand resorption properties
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/56/transtech_doi~10.4028%252Fwww.scientific.net%252FKEM.361-363.1043.pdf
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