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  • 1
    Electronic Resource
    Electronic Resource
    Properties of the Ca2+-ATPase activity of mammalian synaptic membrane preparations (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 27 (1976), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1976.tb00344.x
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  • 2
    Electronic Resource
    Electronic Resource
    Aids in Higher Education (1971)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of educational technology 2 (1971), S. 0 
    Details
    ISSN: 1467-8535
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Education
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-8535.1971.tb00560.x
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  • 3
    Electronic Resource
    Electronic Resource
    Eosinophils from patients with asthma express higher levels of the pan-leucocyte receptor CD45 and the isoform CD45RO (2003)
    Oxford, UK : Blackwell Science Ltd
    Clinical & experimental allergy 33 (2003), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background Eosinophils and their secreted mediators are heavily implicated as effector cells in asthma and other allergic diseases. Comparisons were made between expression of CD45, CD45RA, CD45RB and CD45RO by eosinophils from asthmatic patients and non-asthmatic atopic and non-atopic, non-asthmatic control subjects.Methods Twenty-seven patients with asthma and 33 control subjects were recruited for the study. Eosinophil expression of CD45, CD45RA, CD45RB and CD45RO was established by immunostaining and flow cytometry was performed on whole leucocyte samples. Eosinophil apoptosis in response to CD45 and CD45 isoform monoclonal antibody (mAb)-dependent receptor ligation was assessed by binding of annexin V and flow cytometry.Results Eosinophils from patients with asthma expressed significantly (P〈0.05) higher levels of pan-CD45 and CD45RO compared with eosinophils from non-asthmatic, non-atopic subjects. No significant correlations were found between expression of either pan-CD45 or CD45RO and the degree of symptoms in the asthmatic patients as defined by lung function (FEV1 and FEF25–75) and methacholine PD20. Increased expression of pan-CD45 or CD45RO did not appear to be a consequence of the atopic phenotype. Higher expression of pan-CD45 or CD45RO by eosinophils from asthmatic patients was not associated with greater sensitivity to CD45 and CD45RO mAb receptor ligation-induced eosinophil apoptosis.Conclusion Higher expression of CD45 and CD45RO by eosinophils from asthmatic patients appeared to be a consequence of asthma rather than atopy and further supports a role for activated eosinophils in asthma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2222.2003.01697.x
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  • 4
    Electronic Resource
    Electronic Resource
    Permeability and Excitation of Insect Muscle (1968)
    [s.l.] : Nature Publishing Group
    Nature 217 (1968), S. 970-972 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] If sodium ions enter the cell during the action potential some system must be present to remove them. A sodiumpotassiummagnesiumATPase has recently been found in the plasma membrane of many tissues of other species and is believed to be associated with active cation transport12. A study of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/217970b0
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  • 5
    Electronic Resource
    Electronic Resource
    Properties and Stabilization of the Lysosomal Membrane (1966)
    [s.l.] : Nature Publishing Group
    Nature 210 (1966), S. 1229-1230 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] ALLISON, Magnus and Young1 have recently studied /JL the role of lysosomes in the photosensitization of cells, and from these results Allison2 has presented a unifying hypothesis, implicating lysosomes in carcino-genesis. He suggests that radiation, oncogenic viruses and carcinogenic chemicals have ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2101229a0
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  • 6
    Electronic Resource
    Electronic Resource
    Dystrophin and the integrity of the sarcolemma in Duchenne muscular dystrophy (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 175-177 
    Details
    ISSN: 1420-9071
    Keywords: Dystrophin ; calcium ; skeletal muscle ; muscular dystrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary It is suggested that in Duchenne muscular dystrophy the absence of dystrophin, which is probably a cytoskeletal protein underlying the sarcolemma, causes changes in stretch-activated cation channels rather than direct mechanical tearing of the surface membrane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954866
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  • 7
    Electronic Resource
    Electronic Resource
    Biochemical events associated with rapid cellular damage during the oxygen-and calcium-paradoxes of the mammalian heart (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 41-48 
    Details
    ISSN: 1420-9071
    Keywords: Cardiac muscle ; cell damage ; calcium ; calcium-paradox ; oxygen-paradox ; oxygen radicals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The O2− and Ca2+-paradoxes have a number of features in common and it is suggested that release of cytosolic proteins in both paradoxes is initiated by the activation of a sarcolemma NAD(P)H dehydrogenase which can generate a transmembrane flow of H+ and e− and also oxygen radicals or recox cycling which damage ion channels and membrane proteins (phase I). Entry of Ca2+ through the damaged ion channels then exacerbates the damage by further activating this system, either directly or indirectly, and the redox cycling and/or oxygen radicals cause further damage to integral and cytoskeletal proteins of the sarcolemma resulting in microdamage to the integrity of the membrane (phase II) and the consequent release or exocytosis of cytoplasmic proteins and, under specialised condition, the blebbing of the sarcolemma. The system may be primed either by removal of extracellular Ca2+ or by raising [Ca2+]i by a variety of measures, these two actions being synergistic. The system is initially activated in the Ca2+-paradox by the membrane perturbation associated with removal of extracellular Ca2+; prolonged anoxia in the metabolically active cardiac muscle causes a depletion of the ATP supply, particularly in the absence of glucose, and hence a rise in [Ca2+]i in phase I of the oxygen paradox with the consequent activation of the NAD(P)H oxidase at the sarcolemma. Oxygen radicals are probably generated in both paradoxes and may have a partial role in the genesis of damage, but are not essential in the Ca2+-paradox which continues under anoxia. Massive entry of Ca2+ also activates an intracellularly localised dehydrogenase (probably at the SR) which produces myofilament damage by redox cycling.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01955410
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  • 8
    Electronic Resource
    Electronic Resource
    The action of ouabain in promoting the release of catecholamines (1977)
    Springer
    Cellular and molecular life sciences 33 (1977), S. 923-924 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary It is suggested that ouabain promotes catecholamine release by causing a rise in intracellular Na+ which, in turn, causes an elevated steady-state level of intracellular Ca2+. It is suggested that the Na+−K+-ATPase is not directly involved in exocytosis at either adrenergic or cholinergic synapses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01951283
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  • 9
    Electronic Resource
    Electronic Resource
    The transducer mechanism of sense organs (1964)
    Springer
    Naturwissenschaften 51 (1964), S. 172-173 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00622309
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  • 10
    Electronic Resource
    Electronic Resource
    Role of intracellular calcium in promoting muscle damage: A strategy for controlling the dystrophic condition (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 1531-1535 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary It is suggested that various muscle diseases and examples of experimentally-induced muscle damage arise because of a high calcium level in the myoplasm. When [Ca2+]i is raised experimentally in amphibian or mammalian muscle by treatment with A23187 or caffeine, myofilament degradation follows quickly. Such a rapid action suggests the involvement of a sequence of proteolytic activity that is stimulated by a rise in [Ca2+]i. Ca2+ might either trigger protease activity directly or indirectly, or promote the release of lysosomal enzymes. A high [Ca2+]i in dystrophic muscle is believed to be the resultant of a sequence of events that is summarized in the figure. Suggestions are presented for different ways in which the steady-state position of [Ca2+]i might ultimately be controlled for the clinical amelioration of some dystrophic conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02034655
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