ISSN:
1572-9001
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The high field1H,19F, and13C NMR spectra of haloperidol (HP) in CDCl3 solution were recorded and analyzed with the aid of both homonuclear (H, H-COSY, H, H-COSYLR) and heteronuclear (H,C-COSY) chemical shift correlation experiments. Through space interactions between (1) the piperidine ring and the chlorinated phenyl ring and (2) the fluorinated phenyl ring and a methylene group were identified using phase sensitive Nuclear Overhauser and Exchange Spectroscopy (NOESY). The NOESY results are consistent with a planar structure rather than a folded version of haloperidol.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00678417
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