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Conformational studies of haloperidol (1992)

Keller, Charles E. ; Karr, Paul A. ; Zandler, Melvin E. ; [et al.]

Springer

Structural chemistry 3 (1992), S. 195-201

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ISSN: 1572-9001

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Abstract The high field1H,19F, and13C NMR spectra of haloperidol (HP) in CDCl3 solution were recorded and analyzed with the aid of both homonuclear (H, H-COSY, H, H-COSYLR) and heteronuclear (H,C-COSY) chemical shift correlation experiments. Through space interactions between (1) the piperidine ring and the chlorinated phenyl ring and (2) the fluorinated phenyl ring and a methylene group were identified using phase sensitive Nuclear Overhauser and Exchange Spectroscopy (NOESY). The NOESY results are consistent with a planar structure rather than a folded version of haloperidol.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00678417

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