ISSN:
1432-2307
Keywords:
Giant-cell tumor of bone
;
Chromosome aberrations
;
Translocation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A new case of giant-cell tumour (GCT) of bone with benign histological features, clinical stage II, has been reviewed with immunohistochemistry and electron microscopy. After short-term tissue culture the karyotype, using G-banding techniques, presented a consistent translocation t(12;19)(q13;q13). Nude mice xenografts of the tumour were unsuccessful after 6 months of follow-up. Presence of such chromosomal rearrangement may be related to locally aggressive, histologically benign giant-cell tumors of bone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00718640
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