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  • 1
    Digitale Medien
    Digitale Medien
    Avoidance of direct injury to the peripheral nerve with maxacalcitol (22oxa-1,25(OH)2D3) in rats (2004)
    Melbourne, Australia : Blackwell Science Pty
    Nephrology 9 (2004), S. 0 
    Details
    ISSN: 1440-1797
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Background:  Secondary hyperparathyroidism is one of the most common complications in patients with long-term end-stage renal disease. A recent report has stated that high doses of vitamin D derivatives injected directly into the parathyroid glands can reduce serum parathyroid hormone levels and suppress further enlargement of the parathyroid glands without side-effects. Maxacalcitol (22oxa-1,25(OH)2D3; OCT) is a new vitamin D derivative that can be administered intravenously, and is available in Japan. Direct injection of OCT into enlarged parathyroid glands is a promising new treatment for moderate renal hyperparathyroidism. It is considered to be safe for surrounding tissues, such as peripheral nerves, but the actual effects of OCT on nerves have not yet been documented.Methods:  We measured nerve conduction velocity (NCV) in 24 rat femoral nerves soaked in saline, ethanol, or OCT at various concentrations. Nerves from each group (saline, ethanol, OCT groups) were also examined by microscopy.Results:  The mean NCV of rat femoral nerves was 33.67 ± 1.39 m/s in the saline group. In the OCT group, the velocities were not changed at any of the concentrations tested, and there were no significant differences in NCVs between the saline and OCT groups. In the 50% ethanol group, the velocity decreased significantly to 8.98 ± 4.78 m/s (P 〈 0.01). A histological study demonstrated the nerves soaked in OCT at 10 µg/mL to essentially be intact, while those soaked in anhydrous ethanol were damaged.Conclusions:  This study demonstrated that OCT administration does not affect peripheral NCV, indicating that OCT could possibly be used for the treatment of moderate renal hyperparathyroidism safely without nerve damage.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1797.2004.00250.x
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Ascorbic acid prevents ischemia-reperfusion injury in the rat small intestine (1997)
    Springer
    Transplant international 10 (1997), S. 89-95 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Key words Small intestine ; ascorbic acid ; reperfusion ; Ascorbic acid ; small intestine ; reperfusion ; Reperfusion ; ascorbic acid ; small intestine ; Ischemia ; ascorbic acid ; reperfusion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Ischemia-reperfusion injury by free radicals and lipid peroxides is observed in various organs. Ascorbic acid (AsA) or glutathione (GSH) in various doses (AsA:2, 0.5, 0.1 mmol/kg, GSH:2 mmol/kg) was intraperitoneally administered to male Wistar rats. The entire small intestines were resected just before ischemia, after ischemia, and after 20 min of reperfusion (n = 7–10 at each time point). At each time point, the specimens were subjected to assays of lipid peroxides, GSH, and glutaminase activity of the tissues; they were also examined histologically. In the AsA group, the production of lipid peroxides after reperfusion was significantly suppressed in a dose-dependent manner, and the ratio of oxidized GSH to total GSH was also significantly low. Tissue glutaminase activity decreased to a lesser extent, and the degree of injury was apparently less marked in the AsA group. This study indicates that AsA acts as an antioxidant against peroxidative tissue injury, possibly by scavenging radicals, preserving reduced GSH, and reducing the peroxidative reaction.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s001470050018
    Bibliothek Standort Signatur Band/Heft/Jahr Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Transplantation of kidneys donated from the USA: Long-term results and viability testing using31P-MRS (1996)
    Springer
    Transplant international 10 (1996), S. 7-12 
    Details
    ISSN: 1432-2277
    Schlagwort(e): Organ sharing, Japan, USA ; Japan, USA, organ sharing ; 31P Magnetic resonance spectroscopy, viability ; Viability,31P Magnetic resonance spectroscopy
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Since June 1983, 27 kidneys have been shipped to the Kidney Center at the Tokyo Women's Medical College (TWMC) from the United States. These organs were divided into two groups, based on the years of their donation; 13 kidneys were assigned to group 1 and 14 to group 2. The differences between the two groups were as follows: donor age 19.8 ± 10.0 years vs 51.9 ± 14.5 years in group 2 (P 〈 0.0001); total ischemic time 42 h 12 min in group 1 vs 65 h 42 min in group 2 (P = 0.0002); and Euro-Collins preservation solution in group 1 vs University of Wisconsin (UW) solution in group 2. One hundred percent of the kidneys in group 1 and 85.7 % of those in group 2 recovered their function. The lowest serum creatinine levels averaged 96 ± 38.4 μmol/l and 185.8 ± 101.0 μmol/l, respectively (P = 0.01). The viability of 9 out of 14 grafts in group 2 were tested using31P magnetic resonance spectroscopy (31P-MRS). The results showed that all of the grafts having a monophosphate/inorganic phosphate (MP/Pi) ratio higher than 0.3 recovered their function and those lower than 0.2 did not. The problems associated with international organ sharing are discussed, along with the difficulties encountered at TWMC.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02044335
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