Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    False Neurotransmitters and the Effects of Ethanol on the Brain (1987)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 492 (1987), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1987.tb48695.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Stress-Induced Analgesia: Its Effects on Performance in Learning Paradigms (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 467 (1986), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1986.tb14632.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Catalase and the production of brain acetaldehyde: a possible mediator of the psychopharmacological effects of ethanol (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Addiction biology 2 (1997), S. 0 
    Details
    ISSN: 1369-1600
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: This review represents an attempt to assess the available data on the role of catalase in the mediation of the behavioral actions of ethanol and the regulation of voluntary ethanol consumption. It is argued that acetaldehyde may be formed in brain through the peroxidatic activity of catalase. Furthermore, acetaldehyde formed centrally through the activity of this enzyme, may be responsible, at least in part, for some of the motivational, behavioral and neurotoxic effects of ethanol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1080/13556219772570
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Catalase as a regulator of the propensity to ingest alcohol in genetically determined acatalasemic individuals from Israel (1999)
    Oxford, UK : Blackwell Publishing Ltd
    Addiction biology 4 (1999), S. 0 
    Details
    ISSN: 1369-1600
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Direct descendants of an individual residing in Israel, who was diagnosed in the 1960s with a genetic deficiency in catalase, were examined for their propensity to consume alcohol.These individuals were found to possess a lower level of catalase activity compared to that of a group of matched controls with the same ethnic background.While no differences were observed in the propensity to drink alcohol between the two groups, the catalase deficient individuals did show a significant positive correlation between catalase activity and alcohol drinking behaviour as measured by Q-value. No such relationship was observed in the matched controls.The findings suggest that the apparent acatalasemia in the experimental subjects may act as a limiting factor for these individuals and that catalase may play an important role in regulating alcohol drinking behaviour. These results are consistent with previous animal and human studies which suggest that catalase, via its ability to produce acetaldehyde through the metabolism of ethanol, may have a regulatory role in the propensity to drink alcohol.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1080/13556219971731
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Changes in brain dopamine levels, oocyte growth and spermatogenesis in rainbow trout,Oncorhynchus mykiss, following sublethal cyanide exposure (1991)
    Springer
    Archives of environmental contamination and toxicology 21 (1991), S. 152-157 
    Details
    ISSN: 1432-0703
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Abstract Whole brain dopamine (DA) and norepinephrine (NE) levels were measured in sexually maturing (2 years+) male and female rainbow trout,Oncorhynchus mykiss, following ≍posure to 0.01 mg/L hydrogen cyanide (HCN). Following a 12 day exposure period in July and August 1988, whole brain DA levels of HCN exposed fish were significantly higher (p 〈 0.05), relative to control fish, as measured by high performance liquid chromatography (HPLC). Brain NE levels were unaffected by HCN exposure. Whole brain DA and NE levels showed a strong correlation in control fish (r=+0.81), but not in HCN exposed fish (r=+0.28), likely due to altered DA levels in the latter group. No significant differences were found in brain DA and NE levels between males and females. Mean diameters of oocyte from ovaries of the vitellogenic females were significantly (p 〈 0.01) reduced from 226 to 183 μm in control and HCN exposed fish respectively. Testes from males revealed significantly (p 〈 0.001) higher numbers of spermatogonial cysts in HCN exposed fish. Evidence is given that chronic exposure to sublethal levels of HCN significantly alters brain DA levels in both sexes of rainbow trout, reduces growth in vitellogenic oocytes of the ovary in females and interferes with the passage of spermatogonia to the spermatocyte stage in sexually maturing males. Collectively, these results suggest that sublethal HCN affects the reproductive mechanisms via the hypophyseal-gonad axis in sexually maturing rainbow trout.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01055571
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Exposure to nicotine enhances acquisition of ethanol drinking by laboratory rats in a limited access paradigm (1999)
    Springer
    Psychopharmacology 142 (1999), S. 408-412 
    Details
    ISSN: 1432-2072
    Keywords: Key words Ethanol ; Limited access ; Nicotine ; Mecamylamine HCl ; Rat ; Voluntary intake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Observations in humans suggest that the initial use of tobacco occurs in close temporal proximity to experimentation with alcohol. There have been relatively few research reports, however, examining possible interactions between these two agents. The present experiments examined the effect of nicotine exposure on the acquisition of ethanol drinking behavior in a limited access procedure. In experiment 1, rats were presented with 1-h access to ethanol solutions of increasing concentration for a period of 20 days. Subcutaneous injections of nicotine (0.6 or 1.2 mg/kg salt) or vehicle were administered 30 min prior to each ethanol presentation. Experiment 2 used a similar method, but rats were presented with water along with ethanol during the 1-h test session. Mecamylamine, a nicotinic receptor antagonist, was administered 30 min prior to the nicotine treatment. Nicotine was seen to produce a dose-dependent increase in ethanol drinking behavior which commenced at the 5% ethanol concentration and continued at 8% and again at 10%. In the second experiment, mecamylamine was observed to block completely the nicotine-induced increase in ethanol drinking behavior. The findings suggest that exposure to nicotine can facilitate the acquisition of ethanol drinking behavior in naive rats and that this effect is mediated by nicotine’s interaction at the nicotinic-cholinergic receptor.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002130050906
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Differential ethanol intake in Tryon maze-bright and Tryon maze-dull rats: implications for the validity of the animal model of selectively bred rats for high ethanol consumption (1992)
    Springer
    Psychopharmacology 108 (1992), S. 136-140 
    Details
    ISSN: 1432-2072
    Keywords: Tryon rats ; Ethanol intake ; Selective breeding ; Genetic ; Animal model of alcoholism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The search for a genetically based “animal model of alcoholism” has led to the creation of extensive research programs using various combinations of initial ethanol preference screening techniques and breeding methods to yield rodents with primary genetic differences that contribute to high or low ethanol preference. The present experiment examined the ethanol intake of the Tryon rat strain, which were bred for high and low maze learning scores. It was observed that the Tryon Maze Bright rats displayed an unprecedented affinity for ethanol with stable intakes between 12.7 and 13.7 g/kg per day and preference ratios exceeding 0.75 for ethanol concentrations ranging between 15 and 29%. The pattern of ethanol intake of the Tryon Maze Dull rats resembled the ethanol intake pattern of other, non-selectively bred strains of rats, approximately 2–3 g/kg of absolute ethanol at preference ratios between 0.11 and 0.28. The affinity for ethanol observed for the Tryon Maze Bright rats seems to exceed the reported consumption patterns of rat strains specifically bred for high ethanol consumption although the Tryon rats were selectively bred for variables that were seemingly unrelated to ethanol intake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245298
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Reluctance of rats to drink hashish suspensions: Free-choice and forced consumption, and the effects of hypothalamic stimulation (1974)
    Springer
    Psychopharmacology 35 (1974), S. 129-147 
    Details
    ISSN: 1432-2072
    Keywords: Cannabis ; Self-Administration of Drugs ; Ethanol ; Lateral Hypothalamus ; Electrical Stimulation of Brain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract For over 30 days male Wistar rats drank a concentrated aqueous suspension of hashish in the absence of alternative fluids, but they rejected the drug when water was also made available. In another experiment rats given a choice between water and varying concentrations of hashish also rejected concentrated suspensions, but they appeared less reluctant to drink dilute concentrations. Neither a schedule of alternate-day presentation of hashish nor forced electrical stimulation of lateral hypothalamus induced rats to increase their home-cage intake of an aversive concentration of hashish, suggesting that the enhanced consumption of concentrated ethanol solutions obtained with these two procedures is not due to a nonspecific tendency to ingest any drug offered. Thus rats are generally reluctant to self-administer hashish via the oral route, and their reluctance is not affected by several procedures which can increase their intake of other drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429580
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Differential effects of catecholamine antagonists on ethanol-induced excitation in mice (1990)
    Springer
    Psychopharmacology 102 (1990), S. 234-238 
    Details
    ISSN: 1432-2072
    Keywords: Ethanol ; Dopamine ; Norepinephrine ; Locomotor activity ; Drug antagonists
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Catecholamine antagonists were assessed for their effects on ethanol-induced motor excitation. Motor excitation was measured in male Swiss-Webster mice using an open-field apparatus. Mice were treated with several doses of ethanol and at each dose, mice were pretreated with pimozide, a dopamine D2 antagonist, Schering 23390, a dopamine D1 antagonist, phenoxybenzamine, a noradrenergic alpha-1 antagonist, or yohimbine, a noradrenergic alpha-2 antagonist. Each mouse was subjected to only one dose regimen, and all injections were given IP. Ethanol produced an increase in locomotor activity. The degree to which pimozide attenuated ethanol excitation decreased with increasing ethanol dosage. At the highest dose of ethanol, pimozide increased ethanol excitation. Schering 23390 attenuated ethanol-induced excitation only at doses which affected motor activity per se. Phenoxybenzamine produced a dose-dependent reduction in ethanol excitation. Yohimbine had its greatest effects at the medium dose (4.0 mg/kg). These observations seem to indicate a role for both the dopamine D2 receptor and the noradrenergic alpha-1 receptor in ethanol-induced motor excitation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02245927
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    The reinforcing action of morphine and its paradoxical side effect (1977)
    Springer
    Psychopharmacology 52 (1977), S. 63-66 
    Details
    ISSN: 1432-2072
    Keywords: Morphine ; Lithium chloride ; Reinforcement ; Conditioned taste aversion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats were trained to run down a runway for food in the goal box, and were then tested with one trial per day for 5 days. After running in the runway and eating in the goal box each rat was injected with a drug and returned to the empty goal box for 50 min. Over the 5 trials, rats that received morphine sulphate increased their running speed approximately 400% while the amount of food they ate in the goal box decreased to about 70% of baseline values. The running speed of rats that received lithium chloride decreased to about 30%, while the amount of food they ate decreased to less than 10% of baseline. These two variables did not change for rats that received saline injections. The large increases in running speed observed in the rats that received morphine injections were attributed to an interaction (but not simple summation) between the positive reinforcing effects of morphine and food. The accompanying paradoxical decrease in amount eaten was discussed in terms of the complex pharmacological properties of morphine and it was suggested that morphine may have a reinforcing effect on behavior that is independent of its affective properties.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426601
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...