ISSN:
1741-0444
Schlagwort(e):
Breathing mechanics
;
Parameter estimation
;
Sensitivity analysis
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Chemie und Pharmazie
,
Medizin
Notizen:
Abstract Sensitivity analysis techniques are applied to two classic linear models of breathing mechanics to evaluate the expected accuracy of the parameter estimates to be obtained in different experimental conditions. For this reason the characteristics of the so-called indifference region have been studied, in which the objective function is not significantly affected by changes, in the parameter values. A Mead type or a Otis type configuration was used to characterise the breathing mechanics by computer simulation. For both models four different specific experiments have been simulated which correspond to two types of ventilation (spontaneous breathing and mechanical ventilation) and to two different pathologies (obstructive lung disease and pulmonary rigidness). The results obtained show that the use of the signals which are typical of mechanical ventilation allows very accurate parameter estimates to be obtained in both cases. On the other hand, in spontaneous breathing the estimation of the parameters is more critical, and in this case the Mead model is practically unusable whereas the Otis model supplies results which are still acceptable, even if very sensitive to changes in pathology.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF02447429
Permalink
