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Dysplastic naevus vs. in situ melanoma: digital dermoscopy analysis (2005)

Burroni, M. ; Sbano, P. ; Cevenini, G. ; [et al.]

Oxford, UK : Blackwell Science Ltd

British journal of dermatology 152 (2005), S. 0

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ISSN: 1365-2133

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Background To date, much confusion exists about the biological significance of dysplastic naevi and about the relationship between melanocytic dysplasia and clinical atypia.Objectives To use a digital dermoscopy analyser with a series of ‘borderline’ pigmented skin lesions (i.e. dysplastic naevi and in situ melanomas) to find correlation between the studied variables and to determine their discriminating power with respect to histological diagnosis.Methods The pigmented skin lesions (n = 174) were histologically examined by three experienced dermatopathologists and identified as in situ melanomas (n = 38) and dysplastic naevi (n = 136). The system evaluated 48 parameters as possible discriminant variables, grouped into four categories: geometry, colours, textures and islands of colour. Once the lesions were analysed (stepwise discriminant analysis), sensitivity, specificity and accuracy were calculated.Results At the end of the stepwise procedure the percentage of cases classified correctly was 71·8%. Of 136 dysplastic naevi only 98 were classified correctly, while 27 of 38 in situ melanomas were recognized correctly.Conclusions We conclude that there are so far no digital dermoscopic criteria that can clearly distinguish dysplastic naevi from in situ melanomas.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2133.2005.06481.x

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Influence of experimental conditions on parameter estimation for breathing mechanics: A sensitivity analysis approach (1987)

Avanzolini, G. ; Barbini, P.

Springer

Medical & biological engineering & computing 25 (1987), S. 305-310

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ISSN: 1741-0444

Keywords: Breathing mechanics ; Parameter estimation ; Sensitivity analysis

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology , Medicine

Notes: Abstract Sensitivity analysis techniques are applied to two classic linear models of breathing mechanics to evaluate the expected accuracy of the parameter estimates to be obtained in different experimental conditions. For this reason the characteristics of the so-called indifference region have been studied, in which the objective function is not significantly affected by changes, in the parameter values. A Mead type or a Otis type configuration was used to characterise the breathing mechanics by computer simulation. For both models four different specific experiments have been simulated which correspond to two types of ventilation (spontaneous breathing and mechanical ventilation) and to two different pathologies (obstructive lung disease and pulmonary rigidness). The results obtained show that the use of the signals which are typical of mechanical ventilation allows very accurate parameter estimates to be obtained in both cases. On the other hand, in spontaneous breathing the estimation of the parameters is more critical, and in this case the Mead model is practically unusable whereas the Otis model supplies results which are still acceptable, even if very sensitive to changes in pathology.