ISSN:
1524-475X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Interleukin-1β is produced by numerous cell types including monocytes and fibroblasts. It has been shown to stimulate multiple cell types including fibroblasts, keratinocytes, endothelial cells, neutrophils, macrophages, and lymphocytes. Previously, interleukin-1β was shown to accelerate healing in partial-thickness and full-thickness wounds in animals and was also shown to be safe when applied topically in Phase I human trials. Therefore a prospectively randomized, blind, placebo-controlled trial was performed with patients with chronic pressure ulcers. Doses of interleukin-1β of .01 µg, .10 µg, and 1.0 µg per square centimeter did not show acceleration of healing of the pressure ulcers. Therefore use of recombinant human interleukin-1β in this study was safe but, at the dose levels tested, did not result in improvement in the healing ratio.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1046/j.1524-475X.1994.20307.x
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