ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
The early effects of somatotrophin on the fine structure of the cartilage of the hip joint were studied in growing mice given a single injection of STH, and examined one-half, one, two, four, eight or 24 hours after injection. The first changes, observed as early as one hour after treatment with the hormone, consisted of swelling of the ground plasma and of the pericellular matrix. With increasing interval from the time of injection, acceleration and intensification of organellar development associated with hypertrophy of the cytoplasm were noted: There was increase in the number of RNA granules, of ER lamellae, of multivesicular bodies and of mitochondria as well as hypertrophy of the Golgi apparatus. The mitochondria were swollen, vacuolated or distorted. The appearance of glycogen was hastened. The changes were most marked in superficial and upper midzonal cells, and were still conspicuous 24 hours after the injection. The response of the Golgi apparatus was retarded as compared to that of other organelles. The significance of the findings in relation to cell function is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091510311
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