ISSN:
0003-276X
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Medicine
Notes:
The effect of insulin on the ultrastructure of articular chondrocytes was studied in young dwarf mice (dwdw) which lack pituitary eosinophiles and fail to produce STH. Within less than 24 hours, injections of insulin together with dextrose enhanced development of the endoplasmic reticulum and of the Golgi structures, stimulated the mitochondria, and accelerated and intensified glycogen formation. Dextrose alone had a similar, although less marked effect. The findings suggest a slightly promoting influence of insulin on protein synthesis and a conspicuous stimulation of carbohydrate synthesis by articular chondrocytes of hypopituitary dwarf mice thus treated. The results were compared with those obtained previously after treatment with somatotrophin, and the relationship between these two hormones was discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/ar.1091550410