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  • 1
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 17 (1948), S. 201-226 
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Technology in Society 5 (1983), S. 197-198 
    ISSN: 0160-791X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Sociology , Technology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 165 (1950), S. 528-528 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Several methods have been tried for the isolation and purification of viridin. The procedure described here provides viridin in good yields and gives reproducible results. Viridin was extracted from the culture filtrate with chloroform. After evaporation of the chloroform extract under reduced ...
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 8 (1952), S. 422-424 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary New observations on the necessary cofactors for the hydroxylation of steroids using adrenal homogenates are described. By microbiological hydroxylation of steroids preferably in 11α-position using molds i. a. the new 11-epimers of corticosterone and 17-hydroxy-corticosterone have been obtained. They are lacking high mineralocorticoidal activity.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 9 (1953), S. 371-372 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Certain fungi, especially of the genusFusarium, are capable of rapidly degrading the side chain of 20-keto-pregnenes to the corresponding 17-ketones and, simultaneously, of dehydrogenating ringA. ThusΔ 1,4-3,17-diketo-androstadiene is formed almost quantitatively fromΔ 4-3,20-diketo-pregnenes and fromΔ 4-3,17-diketo-androstene, and in lower yields from the analogousΔ 5-3β-hydroxy compounds. The side chain of saturated 3-keto- or 3β-hydroxy-allopregnane-20-ones is also degraded quickly, but dehydrogenation in ringA proceeds more slowly. 17α-hydroxy-groups prevent the degradation of the side chain. By means of this microbiological process in combination withInhoffen's aromatisation reaction, progesterone can be transformed in only two steps into estrone.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A new group of iron-containing metabolites, with growth stimulating properties for a number of microorganisms, has been isolated from streptomycetes and namedferrioxamines. It is proposed to include them, together with some known substances, like ferrichrome, coprogen and the terregens factor, which either contain or bind iron, in a new class of growth factors, thesideramines. The biological property of the sideramines is counteracted by iron-containing antibiotics from streptomycetes, thesideromycins. They comprise, besides known products like grisein and albomycin, two new groups of antibiotics, among them the highly potentferrimycins.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 16 (1960), S. 355-356 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A strain ofStreptomyces griseus has been found to convert Δ4-3-keto steroids into the corresponding saturated 3-keto-5α-compounds and, on prolonged incubation, into the 3β-hydroxy-5α-derivatives.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 12 (1956), S. 50-52 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A racemic intermediate in the total synthesis ofd, l-aldosterone, thed, l-20-oxo-pregnene derivative I, was converted by incubation with a mold hydroxylating in the 21-position into thed-20-oxo-21-hydroxy-pregnene derivative II, whereas thel-antipode of the starting material remained unchanged. This stereospecific microbiological reaction, comprising a separation of racemic modifications, represents the last remaining step in the synthesis of naturald-aldosterone. Other microbiological conversions of racemic steroids, dehydrogenation and hydrogenation, were also shown to proceed only with thed-enantiomer, leaving thel-form of thed, l-substrate intact. The advantages of this new microbiological method for the resolution of racemic modifications during the total synthesis of steroids are discussed.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 69 (1957), S. 456-463 
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Mikrobiologische Umwandlungen von Steroiden werden technisch verwendet, wenn die chemischen Methoden schwierig oder nicht ausreichend sind. Zunächst wird eine Übersicht über die möglichen Reaktionstypen, wie Hydroxylierung, Dehydrierung, Seitenketten-Abbau, stereospezifische Einwirkung auf Razemate usw. gegeben. Für die mikrobiologische Reaktion wird das gelöste Steroid zur Kultur des betreffenden Mikroorganismus zugegeben; nach einer gewissen Inkubationszeit werden die umgewandelten Steroide extrahiert und direkt oder, wenn Nebenprodukte entstanden sind, durch Gegenstromverteilung oder Chromatographie isoliert. Technisch werden besonders die Hydroxylierung in 11α-, 11β- und 21-Stellung, die 1,2-Dehydrierung sowie der Abbau von Seitenketten benutzt.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 37 (1954), S. 1548-1553 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Some fungi, especially strains of the genus Trichothecium were found to be able of introducing a hydroxy group into the 17 α-position of the steroid molecule. By means of this microbiological process, cortexone was converted into 17 α-hydroxy-cortexone (Reichstein's substance S), 11-dehydro-corticosterone into cortisone, and finally corticosterone into 17 α-hydroxy-corticosterone (hydrocortisone) and cortisone.
    Type of Medium: Electronic Resource
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