ZIB

1

Digitale Medien

[3H]Paroxetine Binding Is Altered in the Hippocampus but Not the Frontal Cortex or Caudate Nucleus from Subjects with Schizophrenia (1995)

Dean, Brian ; Opeskin, Kenneth ; Pavey, Geoffrey ; [weitere]

Oxford, UK : Blackwell Science Ltd

Journal of neurochemistry 64 (1995), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Abstract: [3H]Paroxetine binding to particulate membrane from tissue, obtained at autopsy, from the hippocampus, frontal cortex, and caudate nucleus from subjects who had or had not had schizophrenia was measured. The density of [3H]paroxetine binding to membranes from subjects who had or had not had schizophrenia did not differ. Similarly, the affinity of [3H]paroxetine binding in the frontal cortex and caudate nucleus was not different. By contrast, the affinity of [3H]paroxetine binding to hippocampal membrane from subjects who had schizophrenia was significantly lower than the affinity of binding for the nonschizophrenic subjects (0.40 ± 0.06 vs. 0.26 ± 0.02; p 〈 0.05). As [3H]paroxetine binds to the serotonin transporter, these data suggest that the serotonin transporter is altered in the hippocampus in subjects with schizophrenia.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1471-4159.1995.64031197.x

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2

Digitale Medien

Changes in Serotonin2A and GABAA Receptors in Schizophrenia (1999)

Dean, Brian ; Hussain, Tabasum ; Hayes, Wendy ; [weitere]

Oxford UK : Blackwell Science Ltd

Journal of neurochemistry 72 (1999), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: Abstract: Having shown a decrease in serotonin2A receptors in the dorsolateral prefrontal cortex (DLPFC) from schizophrenic subjects, we have now determined if this change was reflective of widespread changes in neurochemical markers in DLPFC in schizophrenia. In Brodmann’s area (BA) 9 from 19 schizophrenic and 19 control subjects, we confirmed a decrease in the density of [3H]ketanserin binding to serotonin2A receptors in tissue from the schizophrenic subjects [39 ± 3.3 vs. 60 ± 3.6 fmol/mg estimated tissue equivalents (ETE); p 〈 0.005]. In addition, the density of [3H]muscimol binding to GABAA receptors was increased in the schizophrenic subjects (526 ± 19 vs. 444 ± 28 fmol/mg ETE; p 〈 0.02). [3H]YM-09151-2, N-[1-(2-thienyl)cyclohexyl]-3,4-[3H]piperidine, [3H]SCH 23390, [3H]mazindol, and NG-nitro-L-[3H]arginine binding to BA 9 did not differ between groups, and there was no specific binding of [3H]raclopride or 7-hydroxy-2-(di-n-[3H]propylamino)tetralin to BA 9 from either cohort of subjects. This suggests the density of dopamine D1-like and NMDA receptors, the dopamine transporter, and nitric oxide synthase activity are not altered in BA 9 from schizophrenic subjects. The selective nature of the changes in serotonin2A and GABAA receptors in DLPFC could indicate that these changes are involved in the pathology of schizophrenia.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1471-4159.1999.721593.x

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3

Digitale Medien

The cortical serotonin2A receptor and the pathology of schizophrenia: a likely accomplice (2003)

Dean, Brian

Oxford, UK : Blackwell Science Ltd

Journal of neurochemistry 85 (2003), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: A large body of evidence shows that there is a change in the density of cortical serotonin2A receptors (5HT2AR) in post-mortem CNS from subjects with schizophrenia. Furthermore, some antipsychotic drugs have also been shown to cause a decrease in the density of 5HT2AR in the rat CNS. Thus, it appeared possible that changes in this receptor in human post-mortem CNS simply reflected an antipsychotic drug effect. However, a great deal of research on the 5HT2AR and schizophrenia now suggests that the changes in this receptor are complex and may be involved in both the pathology of the disorder and the effects of some antipsychotic drugs. Moreover, recent advances in basic research on the role of the 5HT2AR in the CNS add further support to the hypothesis that the receptor could be involved in the pathology of the illness. In particular, an argument will be developed that the changes in the 5HT2AR in schizophrenia are reflective of a real or perceived change in serotonergic tone and that this forms an important part of the pathology of the illness.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1471-4159.2003.01693.x

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4

Digitale Medien

Proceedings of the Australian Neuroscience Society Symposium: Schizophrenia A PREDICTED CORTICAL SEROTONERGIC/CHOLINERGIC/GABAERGIC INTERFACE AS A SITE OF PATHOLOGY IN SCHIZOPHRENIA (2001)

Dean, Brian

Melbourne, Australia : Blackwell Science Pty

Clinical and experimental pharmacology and physiology 28 (2001), S. 0

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ISSN: 1440-1681

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: 1. The pathological process that precipitates schizophrenia has yet to be identified. However, many lines of evidence suggest that a change in the functioning of the frontal cortex is an important abnormality that underlies schizophrenia.2. Studies in Brodmann’s area 9, obtained post-mortem, have shown changes in 5-hydroxytryptamine 5-HT2A, muscarinic M1 and GABAA receptors in tissue from subjects with schizophrenia.3. Animal studies suggest a site in the cortex where there would be an interaction between serotonergic and cholinergic innervation and that this interaction would involve the 5-HT2A and the M1 receptor. This site, in turn, would be a potent modulator of GABA activity and, hence, levels of GABAA receptors.4. From combining these data, a theoretical site is proposed that, if proven to exist in human cortex, is likely to be central to the pathology of that illness.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1046/j.1440-1681.2001.03401.x

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5

Digitale Medien

Citation heaven (1998)

Dean, Brian

[s.l.] : Macmillan Magazines Ltd.

Nature 395 (1998), S. 9-9

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ISSN: 1476-4687

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Notizen: [Auszug] SirI read the report in Nature with great excitement. At the 1999 Nature Conference on Citation Formats all scientific journals had agreed to use one of three citation formats from 1 January 2000. This was a transition agreement until 1 January 2010 when a single format would ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/25587

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6

Digitale Medien

Ferritin subunits in livers of siderotic mice (1989)

Dean, Brian ; Andrews, Simon C. ; Treffry, Amyra ; [weitere]

Springer

BioMetals 2 (1989), S. 77-82

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ISSN: 1572-8773

Schlagwort(e): Ferritin ; Siderotic mice ; Amino acid sequence ; L subunit

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Chemie und Pharmazie

Notizen: Summary The major ferritin species of mouse liver has been resolved by SDS-PAGE into two bands similar to the H and L subunits of rat liver ferritin with the L subunit predominating. Amino acid sequencing has confirmed the major, faster-migrating component as L chain. An additional, electrophoretically fast, minor ferritin was isolated from siderosome-containing subcellular fractions. In denaturing gels it gave a single ‘F’ subunit band of about 17 kDa, significantly smaller than the L and H subunits (about 20 and 21 kDa respectively). A small fragment isolated from the fast ferritin was sequenced. It corresponds to a 19-residue C-terminal peptide cleaved from L subunits in the assembled molecules. The F subunit must be derived from L subunits by loss of this peptide, and is not the expression product of a different gene. ‘Fast’ ferritins of siderotic mice and rats are thus analogous.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF01129204

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