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  • 1
    Digitale Medien
    Digitale Medien
    Microscopic features of the regeneration of white pulp in autotransplanted spleens in rats (1992)
    Springer
    Virchows Archiv 421 (1992), S. 41-45 
    Details
    ISSN: 1432-2307
    Schlagwort(e): Spleen ; Autotransplantation ; White pulp ; Regeneration ; Rats
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Summary The process of regeneration of white pulp in autotransplanted splenic tissue, implanted into a pocket made by the greater omentum in rats, was investigated histologically and immunohistochemically. Three days after transplantation, almost all implants were necrotic. At day 7, viable splenic tissue had gradually regenerated at the periphery of the implants. At day 10, lymphocytes accumulated around the arterioles. The accumulations resembled the periarteriolar lymphoid sheath of normal spleens in structure, but consisted mainly of B-lymphocytes, with a few scattered T-lymphocytes. However, by week 2, the localization peculiar to T- and B-lymphocytes became definite, and follicular dendritic cells were simultaneously observed in the lymph follicles. This regeneration of the white pulp in the autotransplanted spleens differed from the formation of the white pulp during ontogeny and during recovery after spleen irradiation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01607137
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  • 2
    Digitale Medien
    Digitale Medien
    The granulocyte colony-stimulating factor produced in the human lung and its effect on liquid movement in the rabbit lung (1994)
    Springer
    Surgery today 24 (1994), S. 1050-1055 
    Details
    ISSN: 1436-2813
    Schlagwort(e): granulocyte colony-stimulating factor ; extravascular lung water ; alveolar liquid clearance ; pulmonary resection ; cytokine
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Levels of the granulocyte colony-stimulating factor (G-CSF) were determined in the plasma and resected lung tissue from patients who underwent pulmonary resection. Moreover, the effect of recombinant human (rh) G-CSF on the permeability of pulmonary endothelium and on liquid clearance from the alveolar spaces was investigated in rabbits. The plasma levels of G-CSF increased from 30 pg/ml preoperatively to 409 ± 236 pg/ml 3 h postoperatively (P 〈 0.05), while the levels of G-CSF in the resected lung tissue were increased in the alveolar fluid, to 1,834 ± 1,054 pg/ml, and in the pulmonary blood, to 5,466 ± 2,019 pg/ml. It was found that rh G-CSF 25 μg administered into the subcutaneous tissue of rabbits increased extravascular lung water to 3.45 ± 0.26 vs 2.98 ± 0.20 in control experiments (P 〈 0.05); however, rhG-CSF 0.75 pg/kg administered into the alveloar spaces did not affect liquid clearance from the alveolar spaces. The findings of this study led us to conclude that G-CSF is synthesized in the human lung and increases the permeability of pulmonary endothelium, but not liquid clearance across the alveolar epithelium.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01367455
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  • 3
    Digitale Medien
    Digitale Medien
    Hypothermia inhibits the alveolar epithelial injury caused by hyposmotic albumin solution during preservation of the resected human lung (1997)
    Springer
    Surgery today 27 (1997), S. 527-533 
    Details
    ISSN: 1436-2813
    Schlagwort(e): lung transplantation ; lung injury ; alveolar epithelial cell ; osmolality ; temperature
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract This study was conducted to determine whether hypothermia inhibited alveolar epithelial injury in the resected human lung during preservation. Hyposmotic albumin solution, 248mOsm/kg, was instilled into the alveolar spaces of resected human lungs which were inflated with an airway pressure of 7 cmH2O and stored at either 37°C or 8°C for 4h. Alveolar fluid was aspirated and the influx of lactate dehydrogenase (LDH) and globulin into the alveolar spaces, as markers of alveolar epithelial injury, was measured. Ion transport and fluid clearance across the alveolar epithelium were calculated by the changes in electrolyte and albumin concentrations in the alveolar fluid, respectively. While the LDH levels and globulin concentrations increased significantly in the hyposmotic experiments at 37°C, hypothermia inhibited these increases. Alveolar fluid clearance at 37°C increased to 20% in the hyposmotic experiments compared with 12% in the control isosmotic experiments; however, sodium and chloride transport in the hyposmotic experiments was not significantly different from that in the isosmotic experiments. Thus, we conclude that hypothermia at 8°C inhibits alveolar epithelial injury caused by the hyposmotic solution in resected human lungs. Moreover, alveolar ion and fluid clearance mechanisms were preserved across the injured alveolar epithelial cells.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02385806
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  • 4
    Digitale Medien
    Digitale Medien
    Expression and localization of ossification-related factors in fracture healing: Comparative study of experimental union and non-union models (1996)
    Springer
    Journal of orthopaedic science 1 (1996), S. 193-202 
    Details
    ISSN: 1436-2023
    Schlagwort(e): fracture healing ; bone morphogenetic protein ; immunohistochemistry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The immunohistochemical expression and localization of some ossification-related factors, including a bone growth factor (bone morphogenetic protein, BMP), non-collagenous proteins (osteocalcin, BGP; bone sialoprotein, BSP), and type II collagen, were compared in union and non-union models of fracture healing in rats. In the union model, fracture healing was seen by day 25, whereas the non-union model did not show healing even on day 32. In both models, BMP, BGP, BSP, and type II collagen were expressed mainly in chondrocytes, with proliferating cell nuclear antigen (PCNA)-positive reaction in the soft callus. In the non-union model, the expression of BMP, BGP, BSP, type II collagen, and PCNA disappeared earlier than in the union model. In fracture healing, PCNA-positive cells expressed the ossification-related factors, these being essential for ossification.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02349818
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  • 5
    Digitale Medien
    Digitale Medien
    Serum KL-6, a novel mucin-like glycoprotein, as an indicator of interstitial pneumonitis following lobectomy (1999)
    Springer
    Surgery today 29 (1999), S. 121-128 
    Details
    ISSN: 1436-2813
    Schlagwort(e): KL-6 ; interstitial pneumonitis ; bronchopneumonia ; thoracotomy ; pleural effusion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Serum KL-6 has been shown to be a useful marker of active interstitial pneumonitis in patients who have not undergone lobectomy. Considering that KL-6 is produced mainly in the distal airway epithelium, the present study was conducted to determine whether resected lung volume influenced the postoperative KL-6 levels, and also to evaluate whether it is a useful parameter in patients who have undergone lobectomy. The serum KL-6 levels decreased by 36% 1 week after lobectomy, but returned to the preoperative levels by 2 months postoperatively. Although the KL-6 levels increased by 100% 3 to 4 months after lobectomy, the levels were significantly lower than those in interstitial pneumonitis (P〈0.05). The decrease in the KL-6 levels correlated with the number of resected lung segments, but not with the changes in white blood cell count, lactate dehydrogenase level, or C-reactive protein level. In comparison with the lobectomy patients, the serum KL-6 levels decreased by half in patients who had undergone partial resection (P〈0.05). The results of this study suggest that the serum KL-6 level may be a useful indicator of interstitial pneumonitis after lobectomy. Serum KL-6 levels are influenced by the volume of the resected lung, and probably also by the upregulation of KL-6 production.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02482236
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  • 6
    Digitale Medien
    Digitale Medien
    Adult T-cell leukemia with leukemic cell infiltration in the conjunctiva (1993)
    Springer
    Documenta ophthalmologica 83 (1993), S. 255-260 
    Details
    ISSN: 1573-2622
    Schlagwort(e): Adult T-cell leukemia ; Conjunctiva ; Leukemic cell infiltration
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract A 77-year-old Japanese woman who had suffered from skin eruptions since 1986 was admitted in January, 1990. A diagnosis of adult T-cell leukemia/lymphoma (ATL) was made on the basis of clinical and laboratory data. On admission, erythematous lesions were present in both eyelids. Yellowish-white elevated lesions were found along the limbal conjunctiva, and extended segmentally into the cornea of both eyes. Microscopically, leukemic infiltration into the subepithelial layer of the conjunctiva was observed. Ophthalmic manifestations in ATL have not been well described, because of a little attention paid to them.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01204326
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  • 7
    Digitale Medien
    Digitale Medien
    Increased alveolar fluid clearance following thoracotomy: Report of a case and results of an analysis (1997)
    Springer
    Surgery today 27 (1997), S. 762-765 
    Details
    ISSN: 1436-2813
    Schlagwort(e): pulmonary edema ; ion transport ; lobectomy ; alveolar type II epithelial cell ; human lung
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract Alveolar fluid clearance was studied in the resected lung of a 58-year-old man who had undergone exploratory thoracotomy 9 days earlier. An isosmolar albumin solution was instilled into the distal air spaces, and the albumin and electrolyte concentrations were measured over 4h. Alveolar sodium and fluid clearance had increased by nearly 200% from the control values in the resected lungs of patients without prior thoracotomy (n=5), and histological examination showed that the number of alveolar type II epithelial cells was markedly elevated. These results suggest that an increase in the number of alveolar type II cells may accelerate alveolar fluid clearance under certain clinical conditions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02384993
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  • 8
    Digitale Medien
    Digitale Medien
    Effects of hypothermia and hyperpotassium on alveolar fluid clearance in the resected human lung (1995)
    Springer
    Surgery today 25 (1995), S. 694-700 
    Details
    ISSN: 1436-2813
    Schlagwort(e): pulmonary edema ; potassium concentration ; osmolality ; alveolar epithelium ; lung transplantation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The effect of hypothermia and hyperpotassium on alveolar fluid clearance in the resected human lung was examined by instilling an isosmotic albumin solution with a potassium concentration of 0.3 mEq/l or 20 mEq/l into one segment of a resected lobe within 10 min of surgical removal for bronchogenic carcinoma. The experiments were carried out at 37°C, 25°C, and 8°C over 4h, after which the alveolar fluid was aspirated. Alveolar fluid clearance was calculated by a simple equation using the changes in the albumin concentration of the alveolar fluid. It was found that although hypothermia at 8°C abolished alveolar fluid clearance completely, alveolar fluid clearance at 25°C was not different from that at 37°C. Moreover, although the potassium concentration increased in the alveolar fluid at 37°C and 8°C, hyperpotassium did not affect the alveolar fluid clearance. These findings indicate that the net transport of potassium leans to influx from the alveolar epithelial cells into the alveolar spaces when the alveolar potassium concentration is low, and to efflux from the alveolar spaces when the alveolar potassium concentration is high. Thus, we conclude that hypothermia abolishes alveolar fluid clearance in resected human lungs, but that the potassium concentration in alveolar fluid does not affect alveolar fluid clearance.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00311485
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  • 9
    Digitale Medien
    Digitale Medien
    Serum KL-6, a Novel Mucin-Like Glycoprotein, as an Indicator of Interstitial Pneumonitis Following Lobectomy (1999)
    Springer
    Surgery today 29 (1999), S. 121-128 
    Details
    ISSN: 1436-2813
    Schlagwort(e): Key Words: KL-6 ; interstitial pneumonitis ; bronchopneumonia ; thoracotomy ; pleural effusion
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: P 〈 0.05). The decrease in the KL-6 levels correlated with the number of resected lung segments, but not with the changes in white blood cell count, lactate dehydrogenase level, or C-reactive protein level. In comparison with the lobectomy patients, the serum KL-6 levels decreased by half in patients who had undergone partial resection (P 〈 0.05). The results of this study suggest that the serum KL-6 level may be a useful indicator of interstitial pneumonitis after lobectomy. Serum KL-6 levels are influenced by the volume of the resected lung, and probably also by the upregulation of KL-6 production.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/s005950050372
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