ZIB

Treffer pro Seite

Treffer 1 - 1 | 1 Treffer

Sortierung

Digitale Medien

Nucleic acid metabolism in yeast II. Metabolism of thymidylate during thymidylate excess death (1981)

Toper, Rosa ; Fäth, Wolfgang W. ; Brendel, Martin

Springer

Molecular genetics and genomics 182 (1981), S. 60-64

zur Merkliste hinzufügen auf der Merkliste

Details

ISSN: 1617-4623

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie

Notizen: Summary A discrete class of strains of Saccharomyces cerevisiae, able to utilize, highly efficiently, exogenous deoxythymidine-5′-monophosphate (dTMP), was found to be sensitive to concentrations 〉10 μM dTMP in an otherwise complete growth medium. Excess dTMP is cytostatic and cytotoxic: 90% of exponentially growing cells lose colony forming ability within 1 h of exposure to excess dTMP in a growth medium. Uptake of dTMP, adenine, histidine, and leucine does occur during this thymidylate excess death (TED). dTMP is anabolized to higher phosphorylated nucleotides and catabolized to thymidine intracellularly. DNA synthesis is blocked under TED-conditions but not RNA and protein biosynthesis.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00422767

Permalink

Bibliothek	Standort	Signatur	Band/Heft/Jahr	Verfügbarkeit

Andere fanden auch interessant ...

Artikel (Nationallizenzen)

Volltext

Treffer 1 - 1 | 1 Treffer