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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 25 (1994), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Three cases of familial haemophagocytic lymphohistiocytosis are presented with lung infiltration by haemophagocytic histiocytes. In all patients the diagnosis was based on hepatosplenomegaly, thrombocytopenia and anaemia, abnormal increase in triglycerides, ferritin and LDH, hypofibrinogenaemia and lymphohistiocytosis with haemophagocytosis in bone marrow. Two patients died of respiratory failure due to interstitial pneumonia. In these two patients the pneumonia was obscured and misinterpreted by the pathologists. A careful re-examination revealed lymphohistiocytosis and haemophagocytic cells within the lung parenchyma. The third patient showed alveolar wall infiltration by haemophagocytic histiocytes and lymphocytes. In early childhood acute or recurrent interstitial pneumonia should prompt a search for haemophagocytic histiocytes, and familial haemophagocytic lymphohistiocytosis should be included in the differential diagnosis.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1440
    Keywords: Adrenal insufficiency ; Non-Hodgkin's lymphoma ; Bilateral adrenal masses ; Cortisol replacement therapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Although the adrenal glands are frequently the site of tumor metastases, adrenal insufficiency is exceedingly rare. We report on a patient with high-grade B-cell centroblastic lymphoma who initially presented with right axillary lymphadenopathy and bilateral adrenal masses. Four months after axillary lymphadenectomy the patient developed overt signs of Addison's disease. He recovered promptly after initiation of hormone replacement therapy and bilateral adrenalectomy. At present, 16 months after additional chemo- and radiation therapy the patient is considered free of tumor. To our knowledge this is the first report on a patient who presented with adrenal insufficiency in the course of non-Hodgkin's lymphoma and who was successfully treated. Demonstrating this case, we would also like to stress that the development of adrenal insufficiency does not necessarily indicate widespread tumor manifestation in patients with non-Hodgkin's lymphoma.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1439-0973
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei einer 65jährigen Patientin trat eine Endokarditis durch einen Penicillin-toleranten Stamm vonStreptococcus bovis auf. Die minimale bakterizide Konzentration von Penicillin (40 mg/l) war mehr als 100fach höher als die minimale Hemmkonzentration (0,08 mg/l). In Gegenwart von 1,25 mg/l Gentamicin betrug die MBK von Penicillin 0,31 mg/l. Mittels der zweidimensionalen Echokardiographie konnten am anterioren Segel der Tricuspidalklappe endokarditische Veränderungen sowie an der Aortenklappe eine gestielte Vegetation, die während der Diastole in den linken Ventrikel prolabierte, dargestellt werden. Im Verlauf der Therapie verschwand der gestielte Anteil der Vegetation ohne Anzeichen einer Embolisation. Nach anfänglicher klinischer Besserung verstarb die Patientin schließlich an einer cerebralen Blutung, hervorgerufen durch ein mykotisches Aneurysma derArteria cerebri media sinistra. Es muß daher angenommen werden, daß das Verschwinden des gestielten Anteils der Aortenklappenvegetation einer klinisch stummen Embolie entsprach. Zum Nachweis von Veränderungen in Größe und Form der Vegetation erwies sich die zweidimensionale Echokardiographie gegenüber der eindimensionalen als deutlich überlegen. Die autoptischen Befunde an den Aorten- und Tricuspidalklappen entsprachen den echokardiographischen Befunden.
    Notes: Summary We are presenting a case of endocarditis due to a penicillin-tolerantStreptococcus bovis in a 65-year-old patient. The minimal bactericidal concentration of penicillin (40 mg/l) was more than 100-fold the minimal inhibitory concentration (0.08 mg/l). The MBC of penicillin was 0.31 mg/l in the presence of 1.25 mg/l gentamicin. Cross-sectional echocardiography revealed endocarditis of the anterior leaflet of the tricuspid valve and a vegetation on the aortic valve which appeared to be pedunculated and which prolapsed into the left ventricular outflow tract during diastole. During therapy, the pedunculated part of the vegetation disappeared without signs of embolization. After initial clinical improvement, the patient died of cerebral bleeding caused by a mycotic aneurysm of the left median cerebral artery. The patient's final outcome suggested an asymptomatic embolus. Cross-sectional echocardiography was distinctly superior to M-mode echocardiography in estimating changes in the size and shape of the valve vegetation. The results of the post-mortem examination of the aortic and tricuspid valves corresponded to the echocardiographic findings.
    Type of Medium: Electronic Resource
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