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  • 1
    Electronic Resource
    Electronic Resource
    Civilian penetrating spinal firearm injuries of the spine (1994)
    Springer
    Archives of orthopaedic and trauma surgery 113 (1994), S. 290-293 
    Details
    ISSN: 1434-3916
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In this study, the cases of 17 civilians with penetrating firearm injuries of the spinal cord treated between 1968 and 1990 at the Department of Neurosurgery, Hacettepe University Faculty of Medicine, were analyzed. Relevant literature was reviewed and compared with our study. The results of treatment and other factors determining mortality rate and prognosis were evaluated. Our study and the literature both appear to indicate that operative intervention is the mainstay of treatment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443820
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  • 2
    Electronic Resource
    Electronic Resource
    Ossified adamantinous type craniopharyngiomas (1994)
    Springer
    Acta neurochirurgica 127 (1994), S. 166-169 
    Details
    ISSN: 0942-0940
    Keywords: Craniopharyngioma ; ossification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirteen patients admitted to hospital mainly with visual disturbances (100%), retarded growth (39%) and diabetes insipidus (23%) were all diagnosed as ossified adamantinous craniopharyngioma. Tumour size was found to be large in all patients. Localization displayed a heterogenous dissemination; 8% intra-suprasellar, 69% suprasellar-extraventricular, 15% extra-intraventricular, and 8% in the suprasellar region extending bilaterally to the frontal and temporal lobes. During the early postoperative period, four patients died with hypothalamic deterioration. Three patients underwent a second operation in view of recurrence, and one died from an infection. Thus, the postoperative survival rate was 62%. All the patients who survived continued to have visual disturbances, but only one deteriorated. Five patients exhibited diabetes insipidus during the post-operative period, among them 4 after surgical intervention and 5 patients displayed panhypothyroidism, three of them after surgery. Consequently, it is confirmed by the present review that craniopharyngiomas still offer a potential dilemma in their management. Difficulties caused by adhesion or invasion of ossified craniopharyngiomas and thus the increase in morbidity and mortality during surgical intervention and in the postoperative period are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01808761
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of pinealectomy and foetal pineal transplantation on collagen ageing in rats (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 1224-1229 
    Details
    ISSN: 0942-0940
    Keywords: Pineal gland ; pinealectomy ; transplantation ; collagen ; ageing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Recent progress in pineal research emphasized the importance of this circumventricular organ in the phenomenon of ageing as well. The present study was undertaken to elucidate the effects of pineal gland on collagen ageing by spectrofluorometrically measuring collagen-cross-link bound fluorescein. Experiments were performed on three different age groups of rats (3–4 weeks, 8–10 weeks, 15 and more weeks). Fluorescein values were found to increase causally by age in the control group. Eight weeks after sham operation of all the groups fluorescein level increments were shown to be parallel with the values of normal physiological ageing values. In experimental groups; in 3–5 weeks old rats pinealectomy produced a significant premature collagen ageing and this was found to be completely reversed by foetal pineal gland transplantation, but the reversal was limited to a sham operation level. On the other hand although a premature collagen ageing was found to be induced 8 weeks after pinealectomy in 8–10 weeks old rats with a statistical significance both within subject values and between sham operation and pinealectomy, foetal pineal gland transplantation was found not to reverse the premature ageing induced by pinealectomy. In 15 weeks old and older groups of rats, pinealectomy was found to facilitate the intrinsic ageing phenomenon of collagen with statistical significance again both within subject values and between sham operation and pinealectomy. Foetal pineal gland transplantation was not performed in this age group of rats. On interpretation of the data of pinealectomy against sham operation for all the age groups, the maximum degree of percentage increase in collagen-cross-link bound fluorescein was found in 3–5 weeks old rats (%218). The percentage increase in fluorescein values was found to be %170 and %126 in 8–10 weeks old and 15 weeks old and older rat groups, respectively. Consequently, we have experimentally shown the induction of collagen ageing by pinealectomy and the restorative competence of foetal pineal gland transplantation in the present study. The results seem to be impressive and details of the ageing process are the subject of further research.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809752
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  • 4
    Electronic Resource
    Electronic Resource
    Topical effect of bromocriptine on rat-transplanted human prolactinomas (1993)
    Springer
    Acta neurochirurgica 120 (1993), S. 175-179 
    Details
    ISSN: 0942-0940
    Keywords: Prolactinoma ; bromocriptine ; local application ; experimental tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In prolactinoma surgery, especially in macro-adenomas, it is not always possible to remove the tumour totally. Cell remnants may cause a regrowth and continue hypersecretion. In order to find out whether tumour remnants could be destroyed by local application of bromocriptine, a research model has been designed. First, prolactin secreting pituitary tumours, removed during surgery, were implanted bilaterally into the brain tissue of rats. In eight rats, the viability of tumour transplants was proven histopathologically and their prolactin secretion was shown immunocytochemically. In a second step, on eight rats, sterile bromocriptine solution was applied topically to the tumour transplants on one side. The other side served as control. Histopathological examination of these treated tissues revealed fibrosis. Immunocytochemical analysis showed no secretory activity. Ultrastructural investigations also revealed evidence of degeneration of the treated cells. The natural course of the transplanted tumour tissues of the other side, as a control group, was also observed during the same 55-day period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02112038
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  • 5
    Electronic Resource
    Electronic Resource
    Lipid peroxide level increase in experimental hydrocephalus (1993)
    Springer
    Acta neurochirurgica 121 (1993), S. 68-71 
    Details
    ISSN: 0942-0940
    Keywords: Cerebral vessels ; hydrocephalus ; lipid peroxidation ; sympathetic innervation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aetiology of incomplete adrenergic denervation and reduction in the number and caliber of the cerebral vessels in hydrocephalus is still obscure. Stretching of the blood vessels alone is far from explaining these major vascular changes. Previous studies have shown that increased lipid peroxidation produces toxic effects on vessels. This experimental study was designed to investigate the possible aetiology of vascular changes in hydrocephalic rats with special reference to lipid peroxidation. Hydrocephalus was induced by injecting 50 mg/Kg sterilized kaolin suspension into the cisterna magna in 10 rats (Group A). A sham operation was performed for Group B. After three weeks the rats were anaesthetized and perfused transcardially. The brains were dissected, and cut to visualize the degree of hydrocephalus. The arteries of the circle of Willis were removed for light microscopic examination and the brains were kept for the measurement of lipid peroxidation levels. Light microscopic studies of cerebral arteries in hydrocephalic rats revealed spastic vessels with folding and corrugation of the lamina elastica. The level of lipid peroxidation in group A (260±9.129 nmol TBAR/gr wet tissue) was significantly higher than that of group B (106±3.59 nmol TBAR/gr wet tissue). It is suggested that vascular changes observed in hydrocephalic rats may be due to the high level of lipid peroxidation, which in turn may be the consequence of ischaemia caused by the hydrocephalus related stretching of cerebral vessels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405185
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  • 6
    Electronic Resource
    Electronic Resource
    Efficacy of high dose amino acid solution on spinal cord injury induced by focal Nd : YAG laser irradiation (1995)
    Springer
    Acta neurochirurgica 133 (1995), S. 73-79 
    Details
    ISSN: 0942-0940
    Keywords: Branched chain amino acid solution ; motor evoked potential ; Nd∶YAG laser ; somatosensory evoked potential ; spinal cord injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this experimental study, a neodymium∶yttrium-aluminium-garnet (Nd∶YAG) laser was used to induce highly reproducible focal spinal cord lesions in anaesthetized guinea pigs. The efficacy of high dose amino acid solution (HDAAS) on this injury is investigated. Experiments were performed on 36 animals divided into three groups; sham operated controls, laser irradiated surgical controls, and amino acid groups. Acute responses to injury were evaluated with somatosensory (SSEP) and motor evoked potentials (MEP) and functional recovery was assessed for 8 weeks using the inclined plane technique. In the laser irradiated surgical control group, MEP disappeared one hour after the laser injury, but SSEP revealed changes of amplitude and latency. In this group, the average value of the inclined plane at 24 hours after the laser application was 45.3±1.4 degrees. In the amino acid group, at the sixth hour of injury, MEP and SSEP changes improved with infusion of HDAAS for 4 hours. This improvement was statistically significant (for latency of SSEP U=140 p〈0.05). Inclined plane value at 24 hours after the laser application was 65.5±1.2 degrees in this group. This study showed that application of Nd∶YAG laser irradiation on the spinal cord induced spinal cord injury which presented as paraparesis, HDAAS may provide significant therapeutic protection in secondary damage following this injury and may have a potential role in the treatment of acute spinal cord injury.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01404952
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  • 7
    Electronic Resource
    Electronic Resource
    Low density in the posterior aspect of the intervertebral disk in the patient with herniated nucleus pulposus a prospective study of 50 cases (1991)
    Springer
    Acta neurochirurgica 108 (1991), S. 64-66 
    Details
    ISSN: 0942-0940
    Keywords: CT ; Herniated Nucleus pulposus ; low density area
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary It was previously reported that a low density area in the posterior aspect of the intervertebral disk is an additional computed tomography (CT) finding suggesting a herniated nucleuos pulposus. In this report the incidence of this finding, its correlation with the duration of symptoms and severity of herniation, were studied on 59 herniated intervertebral disks of 50 cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01407668
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  • 8
    Electronic Resource
    Electronic Resource
    Arterial bridging for repair of peripheral nerve gap: a comparative study (1993)
    Springer
    Acta neurochirurgica 121 (1993), S. 181-186 
    Details
    ISSN: 0942-0940
    Keywords: Artery graft ; nerve graft ; nerve regeneration ; nerve tabulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A new experimental model was designed in which the regeneration of rat femoral nerve across a 8 mm excised gap was investigated after insertion of the distal and proximal stumps into the anatomically and functionally intact femoral artery (AIAB). This model was compared with groups of free artery and autologous nerve grafting. After a period of 12 weeks, a histological and electrophysiological analysis was carried out, which demonstrated that the AIAB and autologous nerve grafting group had a significantly higher percentage of regeneration compared with the free artery-graft group. The nerve regeneration and intraneural vascular reconstruction that occured within AIAB group were more successful than those that occured in the artery and nerve-grafting groups.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01809272
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  • 9
    Electronic Resource
    Electronic Resource
    Preventive effect of intracisternal heparin for proliferative angiopathy after experimental subarachnoid haemorrhage in rats (1994)
    Springer
    Acta neurochirurgica 127 (1994), S. 112-117 
    Details
    ISSN: 0942-0940
    Keywords: Experimental subarachnoid haemorrhage ; heparin ; rat ; transmission electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Proliferative angiopathy represents the morphological basis of delayed cerebral vasospasm. The initial vasoconstriction and endothelial damage of the vasospastic arteries leads to an exaggerated response of the smooth muscle cells within the media leading to subintimal thickening and myonecrosis. Heparin reduces the exposure of the media to platelet derived growth factor, a mitogen from aggregating platelets responsible for the migration and proliferation of the myofibroblasts. Since systemic heparin in the setting of a subarachnoid haemorrhage would be unacceptable, we have tested the effect of heparin on proliferative angiopathy by injecting autologous non-heparinized blood into two groups of rats (N=12 each) and then inject the heparin into the spinal fluid of one group after one hour. We were able to show histologically that intracisternal heparin injection after the subarachnoid haemorrhage has reduced the vascular wall changes to a great degree. Heparinization of the cerebrospinal fluid carried out in conjunction with early operation for aneurysms may be a promising approach to prevent the morbid complications of SAH in the clinical setting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01808557
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  • 10
    Electronic Resource
    Electronic Resource
    Spinal injuries in the pediatric age group: a review of 82 cases of spinal cord and vertebral column injuries (1996)
    Springer
    European spine journal 5 (1996), S. 148-152 
    Details
    ISSN: 1432-0932
    Keywords: Pediatric spine ; Spinal cord injury ; Spine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A review of 82 children with spinal cord and/or vertebral column injury treated in our department between 1968 and 1993 showed that 67% of the patients were boys and the average age was 11.4 years. The cause, vertebral level, and type of injury, and the severity of neurological injury varied with the age of the patient. The cause of pediatric injuries differed from that of adult injuries in that falls were the most common causative factor (56%) followed by vehicular accidents (23%). The most frequent level of spinal injury was in the cervical region (57%, 47 patients) followed by the lumbar region (16.5%, 13 patients). In our series, 18% of the patients had complete injury and the overall mortality rate was 3.6%. Eleven children (13%) had spinal cord injury without radiographic abnormality (SCIWORA), whereas 39 (47%) had evidence of neurological injury. Although the spinal injury patterns differed between children and adolescents, the outcome was found to be predominantly affected by the type of neurological injury (P〈0.05). Children with complete myelopathy uniformly remained with severe neurological dysfunction; children with incomplete myelopathy recovered nearly normal neurological function. Finally, the authors conclude that most spinal injuries can be successfuly managed with nonoperative therapy. The literature is reviewed as to the treatment and outcome of pediatric spinal injuries.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00395505
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