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  • 1
    Electronic Resource
    Electronic Resource
    CT cisternography in evaluation of cerebrospinal fluid rhinorrhea (1990)
    Springer
    Neuroradiology 32 (1990), S. 481-484 
    Details
    ISSN: 1432-1920
    Keywords: Cerebrospinal fluid fistula ; CT cisternography ; Iohexol ; Rhinorrhea
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The clinical, radiological and surgical features of 14 patients who presented with cerebrospinal fluid rhinorrhea and had undergone surgical treatment during a three-year period are given with special reference to pre-operative evaluation by CT cisternography. The merits and demerits of this technique are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02426459
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  • 2
    Electronic Resource
    Electronic Resource
    Status epilepticus following iohexol myelography (1993)
    Springer
    Neuroradiology 35 (1993), S. 322-323 
    Details
    ISSN: 1432-1920
    Keywords: Contrast medium ; Iohexol ; Lumbar myelography ; Status epilepticus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Iohexol, a contrast medium widely used for myelography, has rarely been reported to cause convulsive disorders. A case of status epilepticus resulting from iohexol myelography is reported and problems of treatment are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00602626
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  • 3
    Electronic Resource
    Electronic Resource
    Morphological assessment in pinealectomy and foetal pineal gland transplantation in rats: Part I (1994)
    Springer
    Acta neurochirurgica 128 (1994), S. 1-7 
    Details
    ISSN: 0942-0940
    Keywords: Pinealectomy ; transplantation ; wheat-germ agglutinin-horseradish peroxidase (WGA HRP) ; amine histofluorescence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of pineal gland, an endocrine organ known to affect the physiology of various organs and systems including the hypothalamo-hypophyseal axis, on the morphological characteristics of target organs were investigated in rats after pinealectomy and foetal pineal gland transplantation to a subpial cortical area close to the pinealectomized region. It was demonstrated that weight gain was significantly slower in pinealectomized male rats (p〈0.01); pituitary gland weight was lower in the pinealectomized group (p〈0.01) and transplantation had no effect on the weight of this organ; weight of adrenal gland and testis were lower after pinealectomy (p〈0.01) but restored back to control levels after transplantation; the mitotic activity in seminiferous tubules increased with pinealectomy and returned back to control indexes after transplantation. Research on hypothalamic catecholaminergic content revealed a diminished histofluorescence in pinealectomized rats which showed a potentiated restoration after transplantation. The innervation of the pineal gland was studied by anterograde and retrograde injections of Wheat Germ Agglutinin Horse Radish Peroxidase from superior cervical ganglion and pineal gland, respectively. It was demonstrated that cell bodies were traced both at the transplanted tissue and hypothalamus. In view of these data, the multifunctional and a probable high level homeostatic harmony regulator essence of pineal gland is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400645
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  • 4
    Electronic Resource
    Electronic Resource
    Behavioural assessment of pinealectomy and foetal pineal gland transplantation in rats: Part II (1994)
    Springer
    Acta neurochirurgica 128 (1994), S. 8-12 
    Details
    ISSN: 0942-0940
    Keywords: Pinealectomy ; transplantation ; spontaneous locomotor activity ; stereotyped behaviour ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Pineal gland is an endocrine organ which exerts regulatory effects on the activity of various organs and systems. The present study was undertaken to highlight in experimental animals the possible integrative function of this endocrine organ on a behavioural pattern. Pinealectomy and foetal pineal gland transplantation to a subpial cortical area close to the pinealectomized region was performed. Behaviour was defined through motor activity induced by low (2 mg/ kg) and high (10 mg/kg) doses of amphetamine in rats. It was shown that pinealectomy produced significantly different patterns of behaviour induced by low and high doses of amphetamine. In sham operated animals low dose amphetamine induced a significant locomotor stimulation but without stereotyped activity. High dose amphetamine induced stereotyped activity. After pinealectomy even low dose amphetamine preoduced the behavioural pattern of stereotyped activity resembling a high dose amphetamine-induced behaviour. This differential effect of amphetamine, seen in pinealectomized rats, was completely restored after transplantation. On the other hand, melatonin treatment did not generate a significant alteration of behavioural profile either in the control or pinealectomized group of rats. Results are discussed with regard to the general regulatory function of the pineal gland.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400646
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  • 5
    Electronic Resource
    Electronic Resource
    Angiotensin II receptor content within the subfornical organ and organum vasculosum lamina terminalis increases after experimental subarachnoid haemorrhage in rats (1996)
    Springer
    Acta neurochirurgica 138 (1996), S. 460-465 
    Details
    ISSN: 0942-0940
    Keywords: Angiotension II ; autoradiography ; brain ; rat ; receptors ; subarachnoid haemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Nests of cells within the central nervous system, namely the circumventricular organs (CVOs) which include the subfornical organ (SFO), organum vasculosum lamina terminalis (OVLT), area postrema (AP) and the median eminence (ME) are known to contain not only receptors for angiotensin II (ANG II) but also ANG II itself. Though the significance of this central ANG II network in the pathophysiology of certain conditions like hypertension is well established, there appears to be a lack of knowledge as to how this system might be involved after subarachnoid haemorrhage (SAH). In this study, we have investigated ANG II receptor content change at various circumventricular organs after experimental subarachnoid haemorrhage in rats using a transcervical transclivai model. ANG II receptor content was detected by in vivo autoradiography using intracisternal ANG II Sar 1, Ile 8 labelled with iodine (I) 125 both at 30 minutes and 48 hours after the SAH. Serum angiotensin converting enzyme activity was also detected during the time course reflecting the involvement of the peripheral angiotensin system and showed an early rise and a fall after two days. Immunohistochemistry was utilized to show the ANG II-containing cells within the circumventricular organs. SFO and OVLT were found to have a statistically significant increase in ANG II receptor content persisting over two days after the SAH. These alterations in the receptor content of CVOs may indicate their possible role in delayed ischaemic deficits seen after SAH.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01420309
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  • 6
    Electronic Resource
    Electronic Resource
    Infection as a Cause of Spinal Cord Compression: A Review of 36 Spinal Epidural Abscess Cases (2000)
    Springer
    Acta neurochirurgica 142 (2000), S. 17-23 
    Details
    ISSN: 0942-0940
    Keywords: Keywords: Mycobacterium tuberculosis; spinal epidural abscess; spinal infection; tuberculous abscess.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary ¶ A retrospective survey of 36 cases treated in the Department of Neurosurgery, Hacettepe University Hospitals since 1970 was performed. Clinical presentation, aetiology and outcome of this rare disease compared to recently published series. All cases were admitted with signs of neural compression. Clinical and laboratory data suggesting an infectious origin were present only in 4 cases. Radiological investigation including magnetic resonance imaging in 10 patients, were not confirmative for an epidural abscess except for two cases. All cases underwent urgent surgical decompression and tuberculous abscess either in granulation or pus form was found in the majority. Overall mortality rate was 5.8%. Outcome was closely related to the neurological condition on admission rather than the underlying infectious origin. When compared with recently reported series, our cases demonstrated a significant divergence in terms of clinical presentation, pathogenesis and outcome. The most probable reason for this discrepancy is that risk factors for compromised immunity or systemic infection were much less than the other series and mycobacterium tuberculosis is the responsible agent in the majority which has a much more favourable outcome than non-spesific infections.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s007010050002
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  • 7
    Electronic Resource
    Electronic Resource
    Ossified adamantinous type craniopharyngiomas (1994)
    Springer
    Acta neurochirurgica 127 (1994), S. 166-169 
    Details
    ISSN: 0942-0940
    Keywords: Craniopharyngioma ; ossification
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Thirteen patients admitted to hospital mainly with visual disturbances (100%), retarded growth (39%) and diabetes insipidus (23%) were all diagnosed as ossified adamantinous craniopharyngioma. Tumour size was found to be large in all patients. Localization displayed a heterogenous dissemination; 8% intra-suprasellar, 69% suprasellar-extraventricular, 15% extra-intraventricular, and 8% in the suprasellar region extending bilaterally to the frontal and temporal lobes. During the early postoperative period, four patients died with hypothalamic deterioration. Three patients underwent a second operation in view of recurrence, and one died from an infection. Thus, the postoperative survival rate was 62%. All the patients who survived continued to have visual disturbances, but only one deteriorated. Five patients exhibited diabetes insipidus during the post-operative period, among them 4 after surgical intervention and 5 patients displayed panhypothyroidism, three of them after surgery. Consequently, it is confirmed by the present review that craniopharyngiomas still offer a potential dilemma in their management. Difficulties caused by adhesion or invasion of ossified craniopharyngiomas and thus the increase in morbidity and mortality during surgical intervention and in the postoperative period are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01808761
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  • 8
    Electronic Resource
    Electronic Resource
    CSF dynamics in Dandy-Walker syndrome (1990)
    Springer
    Acta neurochirurgica 104 (1990), S. 54-58 
    Details
    ISSN: 0942-0940
    Keywords: Dandy-Walker syndrome ; hydrocephalus ; computerized tomography ; Iohexol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary As neuro-imaging techniques have improved, variations of the Dandy-Walker malformation are being reported. In order to succeed in the therapy and avoid or minimize the complications, the fluid dynamics have to be evaluated by contrast CT studies. We are reporting three different types of this malformation and discuss the therapeutic possibilities.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01842894
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  • 9
    Electronic Resource
    Electronic Resource
    Topical effect of bromocriptine on rat-transplanted human prolactinomas (1993)
    Springer
    Acta neurochirurgica 120 (1993), S. 175-179 
    Details
    ISSN: 0942-0940
    Keywords: Prolactinoma ; bromocriptine ; local application ; experimental tumour
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In prolactinoma surgery, especially in macro-adenomas, it is not always possible to remove the tumour totally. Cell remnants may cause a regrowth and continue hypersecretion. In order to find out whether tumour remnants could be destroyed by local application of bromocriptine, a research model has been designed. First, prolactin secreting pituitary tumours, removed during surgery, were implanted bilaterally into the brain tissue of rats. In eight rats, the viability of tumour transplants was proven histopathologically and their prolactin secretion was shown immunocytochemically. In a second step, on eight rats, sterile bromocriptine solution was applied topically to the tumour transplants on one side. The other side served as control. Histopathological examination of these treated tissues revealed fibrosis. Immunocytochemical analysis showed no secretory activity. Ultrastructural investigations also revealed evidence of degeneration of the treated cells. The natural course of the transplanted tumour tissues of the other side, as a control group, was also observed during the same 55-day period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02112038
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