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  • 1
    Electronic Resource
    Electronic Resource
    The effect of ICI 74,917 on asthma and bronchial provocation tests (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 8 (1978), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A study was made of the protective action of the anti-allergic drug ICI 74,917, a phenanthroline derivative, in specific allergen provocation tests and in combating clinical symptoms in thirteen asthmatic out-patients. It was found that ICI 74,917 was able to diminish allergen-induced bronchoconstriction significantly (P〈 0.01) during both the placebo period and during chronic treatment with ICI 74,917 for 4 weeks. The results obtained during these two periods did not differ significantly. There was not, however, any statistically significant difference in the symptom scores or PEF rates during the treatment with ICI 74,917 or placebo for 1 month. This may indicate that although ICI 74,197 is able to prevent bronchoconstriction in an allergen provocation test, it failed to improve asthma clinically. No signs of the phenomenon of tachyphylaxis were observed in the present study.The Student's t-test was used in the statistical analysis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1978.tb03225.x
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  • 2
    Electronic Resource
    Electronic Resource
    Comparison of ketotifen, disodium cromoglycate and placebo in the treatment of adult patients with mild extrinsic asthma (1981)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 11 (1981), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Sixty-four patients with mild or moderate extrinsic asthma were treated with placebo for i month and thereafter with ketotifen (1 mg twice daily, orally), disodium cromoglycate (inhalation of 20 mg, four times daily), or placebo for 2 subsequent months. The trial was performed at four different centres and the treatments were compared using double-blind technique. We found no difference between the effect of ketotifen, disodium cromoglycate and placebo on the patients' daily measurements of evening peak expiratory flow, daily score values for respiratory symptoms or the number of salbutamol puffs required to control symptoms. There was no difference between the treatment groups with regard to the patients' estimates of changes in airway sensitivity to different non-specific stimuli: fumes, tobacco smoke, cold air, and exercise. The only significant effect of DSCG was a minor (4%) increase in the mean morning value for peak expiratory flow. The findings suggest that the addition of ketotifen or disodium cromoglycate to the regimen is unlikely to give further benefit in asthmatic patients, whose symptoms are reasonably well controlled by small doses of bronchodilating drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1981.tb01589.x
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  • 3
    Electronic Resource
    Electronic Resource
    A 24-SQUID gradiometer for magnetoencephalography
    Amsterdam : Elsevier
    Physica B: Physics of Condensed Matter 165-166 (1990), S. 97-98 
    Details
    ISSN: 0921-4526
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-4526(90)90440-6
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  • 4
    Electronic Resource
    Electronic Resource
    A 24-SQUID gradiometer for magnetoencephalography
    Amsterdam : Elsevier
    Physica B: Physics of Condensed Matter 165-166 (1990), S. 97-98 
    Details
    ISSN: 0921-4526
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0921-4526(90)80898-S
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  • 5
    Electronic Resource
    Electronic Resource
    Binding of 1-3,4-dihydroxyphenylalanine and dopamine in cytoplasmic granules of paneth cells (1969)
    Springer
    Cellular and molecular life sciences 25 (1969), S. 70-72 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nach spezifischer i.v. Injektion wird gefunden, dass Dopamin und 3,4-Dioxyphenylalanin-aminosäure im Zytoplasma der Panethschen Zellen des Mäuseduodenums angehäuft sind. Während Niamid® das meist rasche Verschwinden der Formaldehyd-verursachten Aminfluoreszenz in den Granula von Panethschen Zellen verzögerte, blieb Reserpin wirkungslos.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01903903
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of trasylol® on Paneth cells of the mouse (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 577-578 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nachweis, dass Trasylol®, ein Hemmstoff für proteolytische Enzyme, im Duodenum und Jejunum der Maus eine Zunahme der Panethschen Zellen bewirkt und ausserdem eine Vermehrung der Sekretgranula pro Zelle verursacht.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01932467
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  • 7
    Electronic Resource
    Electronic Resource
    Development of enterochromaffin and dopamine cells in the gastrointestinal tract of the calf (1974)
    Springer
    Cellular and molecular life sciences 30 (1974), S. 1460-1462 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung Nachweis der ersten enterochromaffinen and dopaminen Zellen im Magendarmtraktus des Rindes während der 6. und 7. Woche der Embryonalentwicklung. Die Differenzierung der beiden Zelltypen gelang leicht mittels Fluoreszenz (Formaldehyd), topographischer Verteilung und Zellstruktur. Während die enterochromaffinen Zellen aus den Darmepithelzellen stammen, scheint es sich bei den dopaminen Zellen um Mastzellen zu handeln.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01919694
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  • 8
    Electronic Resource
    Electronic Resource
    Effects of glucagon and insulin on the paneth cells of the mouse duodenum (1975)
    Springer
    Cellular and molecular life sciences 31 (1975), S. 1074-1075 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The effect of glucagon and insulin on the paneth cells (PC) of the duodenum of the mouse was investigated using light microscopy. Both glucagon and insulin were able to increase significantly the number of the secretory granules of PC. This possibly means that these hormones are capable of inhibiting the secretion of PC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02326968
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  • 9
    Electronic Resource
    Electronic Resource
    Activation of the human posterior parietal cortex by median nerve stimulation (1994)
    Springer
    Experimental brain research 99 (1994), S. 309-315 
    Details
    ISSN: 1432-1106
    Keywords: Somatosensory cortex ; Magnetoencephalography ; Evoked response ; Parietal lobe ; Source model ; Human
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We recorded somatosensory evoked magnetic fields from ten healthy, right-handed subjects with a 122-channel whole-scalp SQUID magnetometer. The stimuli, exceeding the motor threshold, were delivered alternately to the left and right median nerves at the wrists, with interstimulus intervals of 1, 3, and 5 s. The first responses, peaking around 20 and 35 ms, were explained by activation of the contralateral primary somatosensory cortex (SI) hand area. All subjects showed additional deflections which peaked after 85 ms; the source locations agreed with the sites of the secondary somatosensory cortices (SII) in both hemispheres. The SII responses were typically stronger in the left than the right hemisphere. All subjects had an additional source, not previously reported in human evoked response data, in the contralateral parietal cortex. This source was posterior and medial to the SI hand area, and evidently in the wall of the postcentral sulcus. It was most active at 70–110 ms.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00239597
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  • 10
    Electronic Resource
    Electronic Resource
    NMR experiments on the superfluid phases of3He in restricted geometries (1976)
    Springer
    Journal of low temperature physics 25 (1976), S. 421-465 
    Details
    ISSN: 1573-7357
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract We report transverse cw NMR measurements on the superfluid phases of3He at temperatures between 3 and 0.7 mK. Nuclear demagnetization of copper was used for refrigeration. For thermometry we employed pulsed NMR on platinum powder immersed in the liquid. The measurements on3He were carried out in two NMR coil assemblies in which the liquid was confined between parallel Mylar foils with separations of 0.37 mm and 4 µm. The transition temperatureT c was measured at pressures between 32 bars and the saturated vapor pressure; a pressure-independent increase of ∼11% was observed inT c with respect to earlier data obtained with the same apparatus. We found that our temperature scale is not proportional to that used in La Jolla. In the 4-µm stack we observe a reduction in the B → A transition temperature. In our measurements on the orientational anisotropy of the B phase we found qualitative agreement with the theory of Brinkman et al. We also measured the longitudinal resonance frequencies of the A and B phases between 32 bars and the polycritical point. In the 4-µm stack we found a negative NMR shift in the A phase when the field was oriented perpendicular to the Mylar plates, in agreement with the prediction of Takagi. The static susceptibility XB of the B phase was measured as a function of temperature at 18.7 and 29 bars; its low-temperature limiting value was observed to be (0.33±0.02)XN , independent of pressure. We use our data to estimate the strong coupling corrections to the size of the energy gap. The initial slope of the reduced gap in the A phase, ΔA/T c , was found to increase by ∼25% when the pressure increased from 21.1 bars to the melting curve, whereas in the low-temperature limit ΔB(0)/T c was found to be independent of pressure and close to its weak coupling value.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00655840
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